||Standard Guide for the 'Salmonella typhimurium'/Mammalian Microsome Tests for Bacterial Mutagenicity.
Claxton, L. D. ;
Mortelmans, K. E. ;
Allen, J. ;
Auletta, A. ;
Nestmann, E. ;
||Health Effects Research Lab., Research Triangle Park, NC.
Test methods ;
Microsome tests ;
||Some EPA libraries have a fiche copy filed under the call number shown.
Since its development by Dr. Bruce Ames and his coworkers, the Salmonella typhimurium/mammalian microsome mutagenicity assay has been used widely throughout the world. Many authors have suggested various modifications and made recommendations in regards to the assay. Although the recommendations of a panel of experts was published in 1979 by deSerres and Shelby, a committee of members of the Environmental Mutagen Society (EMS) initiated the effort in response to the encouragement by the American Society of Testing and Materials (Committe E47.09.01) and because of new developments within the field of microbial mutagenesis tests, but it is not intended for these recommendations to replace or diminish the usefulness of presently available protocols and procedures.