Record Display for the EPA National Library Catalog


Main Title Respiratory Tract Dosimetry of (18)0-Labeled Ozone in Rats: Implications for a Rat-Human Extrapolation of Ozone Dose.
Author Hatch, G. E. ; Wiester, M. J. ; Overton, J. H. ; Aissa, M. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Year Published 1988
Report Number EPA/600/D-88/174;
Stock Number PB88-239017
Additional Subjects Ozone ; Air pollution ; Respiratory system ; Dosimetry ; Laboratory animals ; Humans ; Trachea ; Lung ; Air pollution effects ; Tissue distribution ; Nasopharynx
Library Call Number Additional Info Location Last
NTIS  PB88-239017 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 13p
Efforts to obtain a comparison between rats and humans of the dose of inhaled ozone (O3) delivered to the lungs during O3 exposure has been impeded because of the lack of data on the nasopharyngeal removal of O3 in rats. The present study sought to address the need through use of a newly developed tracing technique that involved oxygen-18 labeled O3 ((18)O3). Comparison of the result to a published value of about 40 percent nasopharyngeal removal in the resting human, yields the conclusion that the O3 concentration in the rat trachea is about 30 percent higher than in the human trachea under similar exposure conditions.