Advancing Actionable Alternatives to Vertebrate Animal Testing for Chemical Safety Assessment

EPA awarded grants to five universities to research the development and use of alternative test methods and strategies that reduce, refine, and/or replace vertebrate animal testing.

Request for Applications closing date: September 25, 2018

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Identifier Abstract Principal Investigator Institution PROJECT PERIOD Project Start Date Project End Date State
<< STAR GRANTS AND STAR CENTERS >>
1 R839501
Grant
Instrumenting phenotypic immunological responses to toxicants that threaten human reproduction Osteen, Kevin G
Bruner-Tran, Kaylon L.
McLean, John
Cliffel, David  
Vanderbilt University Medical Center, Vanderbilt University August 01, 2019 -
July 31, 2022  
August 01, 2019   July 31, 2022   TN  
2 R839502
Grant
Skeletal Teratogenicity of Industrial and Environmental Chemicals Predicted with Human Pluripotent Stem Cells in Vitro zur Nieden, Nicole I
Volz, David C.  
University of California - Riverside August 01, 2019 -
July 31, 2022  
August 01, 2019   July 31, 2022   CA  
3 R839503
Grant
Reducing the reliance on early-life stage testing with relevance to euryhaline fishes: Development and implementation of in-vitro assays predictive of early life stage toxicity and population-level effects in Menidia beryllina Brander, Susanne M
Armbrust, Kevin
Chappell, Patrick
White, Wilson  
Louisiana State University, Oregon State University August 01, 2019 -
July 31, 2022  
August 01, 2019   July 31, 2022    
4 R839504
Grant
A Neurovascular Unit on Chip for Reducing Animals in Organophosphate Neurotoxicology Cliffel, David
May, Jody
McLaughlin, BethAnn  
Vanderbilt University, Vanderbilt University Medical Center August 01, 2019 -
July 31, 2020
(Extended to July 31, 2022)  
August 01, 2019   July 31, 2020
(Extended to July 31, 2022)  
TN  
<< OTHER GRANTS/CENTERS >>
5 R839505
CO-OP
Multiplexed human BrainSphere Developmental Neurotoxicity Test for Six Key Events of Neural Development Lena, Smirnova
Cynthia, Berlinicke
David, Gracias
Romero, J. Carolina
Thomas, Hartung  
The Johns Hopkins University August 01, 2019 -
July 31, 2022  
August 01, 2019   July 31, 2022   MD  



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