Grantee Research Project Results
Research Centers
Southern Center on Environmentally Driven Disparities in Birth Outcomes
Duke University
The central mission of the Southern Center on Environmentally-Driven Disparities in Birth Outcomes is to determine how environmental, social, and host factors jointly contribute to health disparities in birth outcomes. Although it is widely agreed that maternal and fetal health and well-being are determined by multiple forces, surprisingly little is known about the interactions of those forces. For example, elevated environmental exposures often occur in communities facing multiple social stressors like deteriorating housing, inadequate access to health care, poor schools, high unemployment, high crime, and high poverty — all of which may compound the effects of environmental exposures. This phenomenon is especially severe for low income and minority pregnant mothers, with significant health implications for the fetuses they carry. In addition, despite an emerging consensus that numerous gene- environment interactions determine maternal and child health, we know little about how genetic and environmental factors combine to promote or prevent adverse outcomes. This center seeks to disentangle these complicated effects by combining rapidly evolving methods in spatial statistics, genetics, and proteomics, in complementary human and animal models of birth outcomes.
Low birthweight (LBW), preterm birth (PTB), and fetal growth restriction (FGR) all exhibit documented disparities across subpopulations. Survivors of LBW and PTB are at significant risk for both short-term neonatal morbidity as well as long-term disabilities, including respiratory distress syndrome, variable heart rate, cerebral ventriculomegaly, cerebral palsy, mental retardation, blindness, deafness, learning disabilities, behavioral disabilities, and motor impairment. Of similar importance is the impact of lower birth weight on increased risk of diabetes, obesity, cardiovascular disease and other health problems in adulthood. Thus, understanding, and eventually intervening, to prevent these adverse birth outcomes is of critical importance to the overall health of the nation.
Identifier | Abstract | Principal Investigator |
Annual/ Final Reports |
Pubs Count | Institution | Grant Representative |
Grant Amount |
Project Period |
|
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1 |
R830093
Centers - Main center abstract - Center for Air, Climate, and Energy Solutions |
The Center for Environmental Implications of Nanotechnology (CEINT) |
Wiesner, Mark R.
- Principal Investigators listed are sub-PIs determined by the center. |
Duke University, Carnegie Mellon University, Clemson University, Howard University, North Carolina State University, Purdue University, Rice University, Stanford University, University of Kentucky, Virginia Tech | Hahn, Intaek | $1,000,000 |
September 01, 2008 - September 01, 2013 |
||
2 |
R833293
Centers - Main center abstract - The Center for Study of Neurodevelopment and Improving Children's Health |
Southern Center on Environmentally-Driven Disparities in Birth Outcomes |
Miranda , Marie Lynn Ashley-Koch, Allison Auten, Richard Foster, W. Michael Gelfand, Alan Gibson-Davis, Christina Goodall, Jonathan James, Sherman Keating, Martha H. Maxson, Pamela Myers, Evan Reiter, Jerome Speer, Marcy Swamy, Geeta Tootoo, Joshua Williams, Redford - Principal Investigators listed are sub-PIs determined by the center. |
Row 2: 2007
|
Row 2 Total Pubs:
162 Row 2 Journals: 76 Row 2 Books: 1 |
Duke University | Callan, Richard | $7,735,620 |
May 01, 2007 - April 30, 2012 (Extended to April 30, 2014) |
3 |
R834799
Centers - Main center abstract - The Southeastern Center for Air Pollution and Epidemiology: Multiscale Measurements and Modeling of Mixtures |
Multi-Scale Assessment of Health Effects of Air Pollution Mixtures Using Novel Measurements and Models |
Tolbert, Paige Weber, Rodney J. Barry, Vaughn Bergin, Michael Bilonick, Richard Chang, Howard Darrow, Lyndsey Diaz-Sanchez, David Fitzpatrick, Anne Flanders, Dana Greenwald, Roby Guensler, Randy Hu, Yongtao Klein, Mitchel Liu, Yang Mulholland, James Nenes, Athanasios Odman, Mehmet Talat Russell, Armistead G. Sarnat, Jeremy Sarnat, Stefanie Ebelt Strickland, Matthew J Talbott, Evelynn Waller, Lance Winquist, Andrea - Principal Investigators listed are sub-PIs determined by the center. |
Row 3: 2011
|
Row 3 Total Pubs:
338 Row 3 Journals: 135 Row 3 Books: 4 |
Emory University, Georgia Institute of Technology, Duke University | Chung, Serena | $7,999,779 |
January 01, 2011 - December 31, 2016 |
4 |
R835437
Centers - Main center abstract - The Center for Study of Neurodevelopment and Improving Children's Health |
Neurodevelopment and Improving Children's Health following EtS exposure (NICHES) |
Murphy, Susan K. Engelhardt, Barbara Fuemmeler, Bernard Hall, Brandon Hoyo, Cathrine Kollins, Scott H Levin, Edward D Satterwhite, Lisa Schechter, Julia Seidler, Frederick Slotkin, Theodore Wylie, Jamie Zhang, Weiwei - Principal Investigators listed are sub-PIs determined by the center. |
Row 4: 2013
|
Row 4 Total Pubs:
116 Row 4 Journals: 32 Row 4 Books: 6 |
Duke University | Hahn, Intaek | $3,907,780 |
June 01, 2013 - May 31, 2018 (Extended to May 31, 2019) |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.