Research Centers
Southern Center on Environmentally Driven Disparities in Birth Outcomes

Duke University

The central mission of the Southern Center on Environmentally-Driven Disparities in Birth Outcomes is to determine how environmental, social, and host factors jointly contribute to health disparities in birth outcomes. Although it is widely agreed that maternal and fetal health and well-being are determined by multiple forces, surprisingly little is known about the interactions of those forces. For example, elevated environmental exposures often occur in communities facing multiple social stressors like deteriorating housing, inadequate access to health care, poor schools, high unemployment, high crime, and high poverty — all of which may compound the effects of environmental exposures. This phenomenon is especially severe for low income and minority pregnant mothers, with significant health implications for the fetuses they carry. In addition, despite an emerging consensus that numerous gene- environment interactions determine maternal and child health, we know little about how genetic and environmental factors combine to promote or prevent adverse outcomes. This center seeks to disentangle these complicated effects by combining rapidly evolving methods in spatial statistics, genetics, and proteomics, in complementary human and animal models of birth outcomes.

Low birthweight (LBW), preterm birth (PTB), and fetal growth restriction (FGR) all exhibit documented disparities across subpopulations. Survivors of LBW and PTB are at significant risk for both short-term neonatal morbidity as well as long-term disabilities, including respiratory distress syndrome, variable heart rate, cerebral ventriculomegaly, cerebral palsy, mental retardation, blindness, deafness, learning disabilities, behavioral disabilities, and motor impairment. Of similar importance is the impact of lower birth weight on increased risk of diabetes, obesity, cardiovascular disease and other health problems in adulthood. Thus, understanding, and eventually intervening, to prevent these adverse birth outcomes is of critical importance to the overall health of the nation.

Center Publications:

Views: All publications Selected publication types Journal articles Publications submitted after final report

View Projects in List Format

  Identifier Abstract Principal
Investigator
Annual/
Final
Reports
Pubs Count Institution Grant
Representative
Grant
Amount
Project
Period
1 R833293
Centers

- Main center abstract - Southern Center on Environmentally Driven Disparities in Birth Outcomes
Southern Center on Environmentally-Driven Disparities in Birth Outcomes Miranda , Marie Lynn
Ashley-Koch, Allison
Auten, Richard
Foster, W. Michael
Gelfand, Alan
Gibson-Davis, Christina
Goodall, Jonathan
James, Sherman
Keating, Martha H.
Maxson, Pamela
Myers, Evan
Reiter, Jerome
Speer, Marcy
Swamy, Geeta
Tootoo, Joshua
Williams, Redford

- Principal Investigators listed are
sub-PIs determined by the center.
 
2007

2008

2009

2010

2011

2012

Final

Total Pubs: 158
Journals: 72
Books: 1
 
Duke University Callan, Richard   $7,735,620   May 2007 -
April 2012
(Extended to April 2014)  
2 R833293C001
Centers

- This is a subproject of the Southern Center on Environmentally Driven Disparities in Birth Outcomes
Research Project A: Mapping Disparities in Birth Outcomes Miranda , Marie Lynn
Gelfand, Alan
James, Sherman
Maxson, Pamela
Myers, Evan
Swamy, Geeta

- Principal Investigators listed are
sub-PIs determined by the center.
 
2009

2010

2011

Final

Total Pubs: 66
Journals: 36
Books: 1
 
Duke University EPA Project Officer(s) for
Southern Center on Environmentally Driven Disparities in Birth Outcomes

Grant Number R833293:

Callan, Richard  
Refer to main center abstract for funding details.   May 2007 -
April 2012
(Extended to April 2014)  
3 R833293C002
Centers

- This is a subproject of the Southern Center on Environmentally Driven Disparities in Birth Outcomes
Research Project B: Healthy Pregnancy, Healthy Baby: Studying Racial Disparities in Birth Outcomes Williams, Redford
Ashley-Koch, Allison
Auten, Richard
Gibson-Davis, Christina
Maxson, Pamela
Miranda , Marie Lynn
Reiter, Jerome
Swamy, Geeta

- Principal Investigators listed are
sub-PIs determined by the center.
 
2009

2010

2011

Final

Total Pubs: 51
Journals: 26
-- No Books --
 
Duke University EPA Project Officer(s) for
Southern Center on Environmentally Driven Disparities in Birth Outcomes

Grant Number R833293:

Callan, Richard  
Refer to main center abstract for funding details.   May 2007 -
April 2012
(Extended to April 2014)  
4 R833293C003
Centers

- This is a subproject of the Southern Center on Environmentally Driven Disparities in Birth Outcomes
Research Project C: Perinatal Environmental Exposure Disparity and Neonatal Respiratory Health Auten, Richard
Foster, W. Michael

- Principal Investigators listed are
sub-PIs determined by the center.
 
2009

2010

2011

Final

Total Pubs: 18
Journals: 6
-- No Books --
 
Duke University EPA Project Officer(s) for
Southern Center on Environmentally Driven Disparities in Birth Outcomes

Grant Number R833293:

Callan, Richard  
Refer to main center abstract for funding details.   May 2007 -
April 2012
(Extended to April 2014)  
5 R833293C004
Centers

- This is a subproject of the Southern Center on Environmentally Driven Disparities in Birth Outcomes
Community Outreach and Translation Core Keating, Martha H.
Maxson, Pamela
Miranda , Marie Lynn

- Principal Investigators listed are
sub-PIs determined by the center.
 
2009

Final

Total Pubs: 31
Journals: 11
-- No Books --
 
Duke University EPA Project Officer(s) for
Southern Center on Environmentally Driven Disparities in Birth Outcomes

Grant Number R833293:

Callan, Richard  
Refer to main center abstract for funding details.   May 2007 -
April 2012
(Extended to April 2014)  
6 R833293C005
Centers

- This is a subproject of the Southern Center on Environmentally Driven Disparities in Birth Outcomes
Geographic Information System and Statistical Analysis Core Gelfand, Alan
Ashley-Koch, Allison
Goodall, Jonathan
Miranda , Marie Lynn
Reiter, Jerome

- Principal Investigators listed are
sub-PIs determined by the center.
 
2009

Final

  Duke University EPA Project Officer(s) for
Southern Center on Environmentally Driven Disparities in Birth Outcomes

Grant Number R833293:

Callan, Richard  
Refer to main center abstract for funding details.   May 2007 -
April 2012
(Extended to April 2014)