Grantee Research Project Results
Publications Details for Grant Number R835168
Toxicity Screening with Zebrafish Assay
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| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
|---|---|---|---|---|---|---|
| Abstract | Population genetic diversity in zebrafish lines | MAMMALIAN GENOME | Balik-Meisner M, Truong L, Scholl E, Tanguay R, Reif D | Balik-Meisner M, Truong L, Scholl E, Tanguay R, Reif D. Population genetic diversity in zebrafish lines. MAMMALIAN GENOME 2018;29(1-2):90-100 |
R835168 (Final) R835796 (Final) |
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| Journal Article | Phenotype anchoring in zebrafish reveals a potential role for matrix metalloproteinases (MMPs) in tamoxifen's effects on skin epithelium. | TOXICOLOGY AND APPLIED PHARMACOLOGY | Bugel SM, Wehmas LC, La Du JK, Tanguay RL | Bugel SM, Wehmas LC, La Du JK, Tanguay RL. Phenotype anchoring in zebrafish reveals a potential role for matrix metalloproteinases (MMPs) in tamoxifen's effects on skin epithelium. Toxicology and Applied Pharmacology 2016;296:31-41. |
R835168 (Final) |
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| Journal Article | Advancements in zebrafish applications for 21st century toxicology. | PHARMACOLOGY & THERAPEUTICS | Garcia GR, Noyes PD, Tanguay RL | Garcia GR, Noyes PD, Tanguay RL. Advancements in zebrafish applications for 21st century toxicology. Pharmacology & Therapeutics 2016;161:11-21. |
R835168 (Final) |
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| Journal Article | High-throughput characterization of chemical-associated embryonic behavioral changes predicts teratogenic outcomes. | ARCHIVES OF TOXICOLOGY | Reif DM, Truong L, Mandrell D, Marvel S, Zhang G, Tanguay RL | Reif DM, Truong L, Mandrell D, Marvel S, Zhang G, Tanguay RL. High-throughput characterization of chemical-associated embryonic behavioral changes predicts teratogenic outcomes. Archives of Toxicology 2016;90(6):1459-1570. |
R835168 (Final) |
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| Journal Article | Optimizing multi-dimensional high throughput screening using zebrafish. | REPRODUCTIVE TOXICOLOGY | Truong L, Bugel SM, Chlebowski A, Usenko CY, Simonich MT, Simonich SLM, Tanguay RL | Truong L, Bugel SM, Chlebowski A, Usenko CY, Simonich MT, Simonich SLM, Tanguay RL. Optimizing multi-dimensional high throughput screening using zebrafish. Reproductive Toxicology 2016;65:139-147. |
R835168 (Final) R835796 (2017) |
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| Journal Article | A new statistical approach to characterize chemical-elicited behavioral effects in high-throughput studies using zebrafish. | PLOS ONE | Zhang GZ, Truong L, Tanguay RL, Reif DM | Zhang G, Truong L, Tanguay RL, Reif DM. A new statistical approach to characterize chemical-elicited behavioral effects in high-throughput studies using zebrafish. PLoS One 2017;12(1):e0169408 (16 pp.). |
R835168 (Final) R835796 (2017) |
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| Journal Article | Aggregate entropy scoring for quantifying activity across endpoints with irregular correlation structure. | REPRODUCTIVE TOXICOLOGY | Zhang G, Marvel S, Truong L, Tanguay RL, Reif DM | Zhang G, Marvel S, Truong L, Tanguay RL, Reif DM. Aggregate entropy scoring for quantifying activity across endpoints with irregular correlation structure. Reproductive Toxicology 2016;62:92-99. |
R835168 (Final) R835796 (2017) R835802 (2015) R835802 (2016) R835802 (2017) R835802 (2018) R835802C003 (2015) |
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| Journal Article | A data-driven weighting scheme for multivariate phenotypic endpoints recapitulates zebrafish developmental cascades. | None | Zhang G, Roell KR, Truong L, Tanguay RL, Reif DM | Zhang G, Roell KR, Truong L, Tanguay RL, Reif DM. A data-driven weighting scheme for multivariate phenotypic endpoints recapitulates zebrafish developmental cascades. Toxicology and Applied Pharmacology 2017;314:109-117. |
R835168 (Final) |
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| Presentation | Mining ToxCast™ phase I and II embryonic zebrafish data for possible endocrine disrupting chemicals for transcriptomics and predictive modeling. | None | Haggard DE, Tilton F, Waters K, Tanguay RL | Haggard DE, Tilton F, Waters K, Tanguay RL. Mining ToxCast™ phase I and II embryonic zebrafish data for possible endocrine disrupting chemicals for transcriptomics and predictive modeling. Poster presented at the Collaborative Workshop on Aquatic Models and 21st Century Toxicology, Raleigh, NC, May 5, 2014. |
R835168 (Final) |
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| Presentation | Phenotypically-anchored transcriptomic response in embryonic zebrafish developmentally exposed to the antimicrobial agent, Triclosan. | None | Haggard DE, Noyes PD, Tilton F, Thomas D, Waters KM, Tanguay RL | Haggard DE, Noyes PD, Tilton F, Thomas D, Waters KM, Tanguay RL. Phenotypically-anchored transcriptomic response in embryonic zebrafish developmentally exposed to the antimicrobial agent, Triclosan. Presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835168 (Final) |
not available |
| Presentation | A strategy for the design of safer products. | None | Tanguay RL | Tanguay RL. A strategy for the design of safer products. Presented at the Design of Safer Chemicals and Products: The Nexus of Toxicology and Chemistry, McMenamins' Edgefield, Troutdale, OR, April 23-24, 2015. |
R835168 (2014) R835168 (Final) |
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| Presentation | Coupling the power of high throughput zebrafish screening and synthetic chemistry to design safer chemicals. | None | Tanguay RL | Tanguay RL. Coupling the power of high throughput zebrafish screening and synthetic chemistry to design safer chemicals. Presented at the 250th American Chemical Society National Meeting, Boston, MA, August 16-20, 2015. |
R835168 (2014) R835168 (Final) R835796 (2015) R835796 (2016) |
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| Presentation | High throughput assessment of bioactivity using zebrafish: high content data for the 21st century. | None | Tanguay RL | Tanguay RL. High throughput assessment of bioactivity using zebrafish: high content data for the 21st century. Presented at the Oklahoma State University, Stillwater OK, February 19, 2015. |
R835168 (2014) R835168 (Final) R835580 (2015) R835580 (2016) R835580 (2017) R835580 (2018) R835796 (2015) |
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| Presentation | Using multidimensional zebrafish data to advance environmental health. | None | Tanguay RL | Tanguay RL. Using multidimensional zebrafish data to advance environmental health. Presented at Elucidating Environmental Dimensions of Neurological Disorders and Diseases: Understanding New Tools from Federal Chemical Testing Programs, Environmental Defense Fund, University of California, Davis, Davis, CA, June 20, 2015. |
R835168 (2014) R835168 (Final) R835796 (2015) |
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| Presentation | Using zebrafish as a high-throughput non-mammalian in vivo model to identify DNT compounds. | None | Tanguay RL | Tanguay RL. Using zebrafish as a high-throughput non-mammalian in vivo model to identify DNT compounds. Presented at the American Association for Laboratory Animal Science (AALAS) 66th National Meeting, Phoenix, AZ, November 1-5, 2015. |
R835168 (2014) R835168 (Final) R835796 (2015) |
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| Presentation | Whole-genome expression analysis of endocrine active ToxCast™ compounds in embryonic zebrafish. | None | Tanguay RL | Tanguay RL. Whole-genome expression analysis of endocrine active ToxCast™ compounds in embryonic zebrafish. Presented at the Society of Toxicology's FutureTox III: Transforming 21st Century Science into Risk Assessment and Regulatory Decision-Making, Arlington, VA, November 20, 2015. |
R835168 (Final) |
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| Presentation | Exploiting zebrafish as a sensor for chemical bioactivity. | None | Tanguay RL | Tanguay RL. Exploiting zebrafish as a sensor for chemical bioactivity. Presented at the Boston University Mini-Symposium: Experimental and Computational Approaches to Cancer Risk Assessment from Chemical [and Drug] Exposure, Boston MA, November 30, 2015. |
R835168 (2014) R835168 (Final) R835796 (2016) |
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| Presentation | Using multidimensional zebrafish data to advance environmental health science. | None | Tanguay RL | Tanguay RL. Using multidimensional zebrafish data to advance environmental health science. Presented at the University of Illinois, Urbana, IL, October 6, 2015. |
R835168 (2014) R835168 (Final) R835796 (2015) R835796 (2016) R835796 (2017) |
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| Presentation | Using zebrafish phenotypic and transcriptomic screening to define potential endocrine activity. | None | Tanguay RL | Tanguay RL. Using zebrafish phenotypic and transcriptomic screening to define potential endocrine activity. Presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 15, 2016. |
R835168 (Final) |
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| Presentation | Harnessing the in vivo power of zebrafish to unraveling complex toxicity mechanisms. | None | Tanguay R | Tanguay R. Harnessing the in vivo power of zebrafish to unraveling complex toxicity mechanisms. Presented at the University of California, Los Angeles, Los Angeles, CA, April 25, 2013. |
R835168 (2013) |
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| Presentation | Harnessing the power of zebrafish to protect and improve human health. | None | Tanguay R | Tanguay R. Harnessing the power of zebrafish to protect and improve human health. Presented at the University of Mississippi, Oxford, MS, April 29, 2013. |
R835168 (2013) |
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| Presentation | In vivo behavioral and morphological screening of a 1078 chemical library using zebrafish. | None | Tanguay R | Tanguay R. In vivo behavioral and morphological screening of a 1078 chemical library using zebrafish. Presented at the 14th International Neurotoxicology Association Meeting (INA14), Egmond aan Zee, Netherlands, June 13, 2013. |
R835168 (2013) |
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| Presentation | Rapid in vivo assessment of chemical and biological interactions: high content data for the 21st century. | None | Tanguay R | Tanguay R. Rapid in vivo assessment of chemical and biological interactions: high content data for the 21st century. Presented at the Department of Pharmaceutical Sciences, University of New Mexico, Albuquerque, New Mexico, March 29, 2013. |
R835168 (2013) |
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| Presentation | Harnessing the power of zebrafish to advance environmental health sciences: high content data for 21st century toxicology. | None | Tanguay R | Tanguay R. Harnessing the power of zebrafish to advance environmental health sciences: high content data for 21st century toxicology. Presented at the University of California, Riverside, Riverside, CA, May 22, 2013. |
R835168 (2013) |
not available |
| Presentation | Exploiting multi-dimensional high throughput screening in zebrafish to protect human health. | None | Tanguay R | Tanguay R. Exploiting multi-dimensional high throughput screening in zebrafish to protect human health. North Carolina State University, Raleigh, NC, November 19, 2013. |
R835168 (2013) |
not available |
| Presentation | Multi-dimensional in vivo screening of the ToxCast chemicals using embryonic zebrafish. | None | Tanguay R | Tanguay R. Multi-dimensional in vivo screening of the ToxCast chemicals using embryonic zebrafish. Presented at the U.S. Environmental Protection Agency's National Center for Computational Toxicology, National Toxicology Program, Research Triangle Park, NC, November 6, 2013. |
R835168 (2013) |
not available |
| Presentation | Coupling site specific passive sampling devices and the embryonic zebrafish model to define the toxicity of environmentally relevant mixtures. | None | Tanguay R | Tanguay R. Coupling site specific passive sampling devices and the embryonic zebrafish model to define the toxicity of environmentally relevant mixtures. Presented at the Superfund Research Program Annual Meeting, Louisiana State University Superfund Research Center, Baton Rouge, LA. October 16, 2013. |
R835168 (2013) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.