Grantee Research Project Results
Publications Details for Grant Number R834796C003
Cardiovascular Consequences of Immune Modification by Traffic-Related Emissions
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Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
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Abstract | Diesel exhaust induces hyperlipidemia in association with downregulation of PPAR alpha and changes in gut microbiota. | None | Yin F, Driscoll WS, Sulaiman D, Ramanathan G, Stewart JA, Mehrabian M, Beaven S, Lusis AJ, Rosenfeld ME, Araujo JA | Yin F, Driscoll WS, Sulaiman D, Ramanathan G, Stewart JA, Mehrabian M, Beaven S, Lusis AJ, Rosenfeld ME, Araujo JA. Diesel exhaust induces hyperlipidemia in association with downregulation of PPAR alpha and changes in gut microbiota. Circulation 2016;134(Suppl 1):A20762. |
R834796C003 (Final) |
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Abstract | Diesel exhaust induces hyperlipidemia in association with downregulation of PPAR alpha and changes in gut microbiota. | None | Yin F, Driscoll WS, Sulaiman D, Ramanathan G, Stewart JA, Mehrabian M, Beaven S, Lusis AJ, Rosenfeld ME, Araujo JA. | Yin F, Driscoll WS, Sulaiman D, Ramanathan G, Stewart JA, Mehrabian M, Beaven S, Lusis AJ, Rosenfeld ME, Araujo JA. Diesel exhaust induces hyperlipidemia in association with downregulation of PPAR alpha and changes in gut microbiota. Circulation 2016;134(Suppl 1):A20762 |
R834796 (2016) R834796C003 (2016) |
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Journal Article | Inflammatory and vasoactive effects of serum following inhalation of varied complex mixtures. | CARDIOVASCULAR TOXICOLOGY | Aragon MJ, Chrobak I, Brower J, Roldan L, Fredenburgh LE, McDonald JD, Campen MJ | Aragon MJ, Chrobak I, Brower J, Roldan L, Fredenburgh LE, McDonald JD, Campen MJ. Inflammatory and vasoactive effects of serum following inhalation of varied complex mixtures. Cardiovascular Toxicology 2016;16(2):163-171. |
R834796 (2015) R834796 (Final) R834796C003 (2015) R834796C003 (Final) |
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Journal Article | Metabolomic changes in murine serum following inhalation exposure to gasoline and diesel engine emissions. | None | Brower JB, Doyle-Eisele M, Moeller B, Stirdivant S, McDonald JD, Campen MJ | Brower JB, Doyle-Eisele M, Moeller B, Stirdivant S, McDonald JD, Campen MJ. Metabolomic changes in murine serum following inhalation exposure to gasoline and diesel engine emissions. Inhalation Toxicology 2016;28(5):241-250. |
R834796 (2016) R834796 (Final) R834796C003 (2016) R834796C003 (Final) |
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Journal Article | Mechanisms linking traffic-related air pollution and atherosclerosis. | CURRENT OPINION IN PULMONARY MEDICINE | Campen MJ, Lund A, Rosenfeld M | Campen MJ, Lund A, Rosenfeld M. Mechanisms linking traffic-related air pollution and atherosclerosis. Current Opinion in Pulmonary Medicine 2012;18(2):155-160. |
R833990 (2010) R833990 (2011) R834796 (2012) R834796 (2013) R834796 (2015) R834796 (Final) R834796C003 (2012) R834796C003 (2013) R834796C003 (Final) |
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Journal Article | Engine exhaust particulate and gas phase contributions to vascular toxicity. | None | Campen M, Robertson S, Lund A, Lucero J, McDonald J | Campen M, Robertson S, Lund A, Lucero J, McDonald J. Engine exhaust particulate and gas phase contributions to vascular toxicity. Inhalation Toxicology 2014;26(6):353-360. |
R834796 (2014) R834796 (2015) R834796 (Final) R834796C003 (Final) |
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Journal Article | The effects of α-pinene versus toluene-derived secondary organic aerosol exposure on the expression of markers associated with vascular disease. | None | Lund AK, Doyle-Eisele M, Lin Y-H, Arashiro M, Surratt JD, Holmes T, Schilling KA, Seinfeld JH, Rohr AC, Knipping EM, McDonald JD | Lund AK, Doyle-Eisele M, Lin Y-H, Arashiro M, Surratt JD, Holmes T, Schilling KA, Seinfeld JH, Rohr AC, Knipping EM, McDonald, JD. The effects of α-pinene versus toluene-derived secondary organic aerosol exposure on the expression of markers associated with vascular disease. Inhalation Toxicology 2013;25(6):309-324. |
R833990 (2011) R834796 (2013) R834796 (2014) R834796 (2015) R834796 (Final) R834796C002 (2015) R834796C002 (Final) R834796C003 (2013) |
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Journal Article | Ozone inhalation impairs coronary artery dilation via intracellular oxidative stress: evidence for serum-borne factors as drivers of systemic toxicity. | TOXICOLOGICAL SCIENCES | Paffett ML, Zychowski KE, Sheppard L, Robertson S, Weaver JM, Lucas SN, Campen MJ | Paffett ML, Zychowski KE, Sheppard L, Robertson S, Weaver JM, Lucas SN, Campen MJ. Ozone inhalation impairs coronary artery dilation via intracellular oxidative stress: evidence for serum-borne factors as drivers of systemic toxicity. Toxicological Sciences 2015;146(2):244-253. |
R834796 (2014) R834796 (2015) R834796 (Final) R834796C003 (Final) |
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Journal Article | CD36 mediates endothelial dysfunction downstream of circulating factors induced by O3 exposure. | None | Robertson S, Colombo ES, Lucas SN, Hall PR, Febbraio M, Paffett ML, Campen MJ | Robertson S, Colombo ES, Lucas SN, Hall PR, Febbraio M, Paffett ML, Campen MJ. CD36 mediates endothelial dysfunction downstream of circulating factors induced by O3 exposure. Toxicological Sciences 2013;134(2):304-311. |
R833990 (2011) R833990 (Final) R834796 (2013) R834796 (2014) R834796 (2015) R834796 (Final) R834796C003 (2013) R834796C003 (2016) R834796C003 (Final) |
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Journal Article | Endothelial inflammatory transcriptional responses to an altered plasma exposome following inhalation of diesel emissions. | None | Schisler JC, Ronnebaum SM, Madden M, Channell M, Campen M, Willis MS | Schisler JC, Ronnebaum SM, Madden M, Channell M, Campen M, Willis MS. Endothelial inflammatory transcriptional responses to an altered plasma exposome following inhalation of diesel emissions. Inhalation Toxicology 2015;27(5):272-280. |
R834796 (2015) R834796 (Final) R834796C003 (Final) |
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Journal Article | Transcriptional Endothelial Biosensor Response to Diesel-Induced Plasma Compositional Changes. | None | Schisler J, Campen MJ, Madden M, Willis MS | Schisler J, Campen MJ, Madden M, and Willis MS. Transcriptional Endothelial Biosensor Response to Diesel-Induced Plasma Compositional Changes. Inhalation Toxicology. 2015, 27(5):272–280. |
R834796C003 (2016) |
not available |
Journal Article | Surface area-dependence of gas-particle interactions influences pulmonary and neuroinflammatory outcomes. | PARTICLE AND FIBRE TOXICOLOGY | Tyler CR, Zychowski KE, Sanchez BN, Rivero V, Lucas S, Herbert G, Liu J, Irshad H, McDonald JD, Bleske BE, Campen MJ | Tyler CR, Zychowski KE, Sanchez BN, Rivero V, Lucas S, Herbert G, Liu J, Irshad H, McDonald JD, Bleske BE, Campen MJ. Surface area-dependence of gas-particle interactions influences pulmonary and neuroinflammatory outcomes. Particle and Fibre Toxicology 2016;13(1):64 (18 pp.). |
R834796 (2016) R834796 (Final) R834796C003 (Final) |
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Journal Article | Diesel exhaust induces systemic lipid peroxidation and development of dysfunctional pro-oxidant and pro-inflammatory high-density lipoprotein. | None | Yin F, Lawal A, Ricks J, Fox JR, Larson T, Navab M, Fogelman AM, Rosenfeld ME, Araujo JA | Yin F, Lawal A, Ricks J, Fox JR, Larson T, Navab M, Fogelman AM, Rosenfeld ME, Araujo JA. Diesel exhaust induces systemic lipid peroxidation and development of dysfunctional pro-oxidant and pro-inflammatory high-density lipoprotein. Arteriosclerosis, Thrombosis, and Vascular Biology 2013;33(6):1153-1161. |
R834796 (2013) R834796 (2014) R834796 (2015) R834796 (Final) R834796C003 (2013) R834796C003 (2016) R834796C003 (Final) |
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Journal Article | Arterioscler Thromb Vasc Biol. | None | Peroxidation Development of Dysfunctional Pro-Oxidant Pro-Inflammatory High-Density Lipoprotein | Peroxidation and Development of Dysfunctional Pro-Oxidant and Pro-Inflammatory High-Density Lipoprotein. Arterioscler Thromb Vasc Biol. 2013, 33(6):1153-61. |
R834796C003 (2016) |
not available |
Journal Article | Cardiovascular toxicology. | None | Aragon MJ, Chrobak I, Brower J, Roldan L, Fredenburgh LE, McDonald JD, Campen MJ:Inflammatory Vasoactive Effects of Serum Following Inhalation of Varied Complex Mixtures | Aragon MJ, Chrobak I, Brower J, Roldan L, Fredenburgh LE, McDonald JD, Campen MJ:Inflammatory and Vasoactive Effects of Serum Following Inhalation of Varied Complex Mixtures. Cardiovascular toxicology. 2016, 16(2):163-171. |
R834796C003 (2016) |
not available |
Journal Article | Current opinion in pulmonary medicine. | None | Campen MJ, Lund A, Rosenfeld M:Mechanisms linking traffic-related air pollution atherosclerosis | Campen MJ, Lund A, Rosenfeld M:Mechanisms linking traffic-related air pollution and atherosclerosis. Current opinion in pulmonary medicine. 2012, 18(2):155. |
R834796C003 (2016) |
not available |
Journal Article | Inhalation toxicology. | None | Campen M, Robertson S, Lund A, Lucero J, McDonald J:Engine exhaust particulate gas phase contributions to vascular toxicity | Campen M, Robertson S, Lund A, Lucero J, McDonald J:Engine exhaust particulate and gas phase contributions to vascular toxicity. Inhalation toxicology. 2014, 26(6):353-360. |
R834796C003 (2016) |
not available |
Journal Article | Ozone inhalation enhances coronary artery constriction and impairs dilation via superoxide-dependent mechanisms. | None | Paffett ML, Sheppard L, Robertson S, Weaver J, Lucas SN, Campen MJ | Paffett ML, Sheppard L, Robertson S, Weaver J, Lucas SN, Campen MJ. Ozone inhalation enhances coronary artery constriction and impairs dilation via superoxide-dependent mechanisms. Toxicol Appl Pharmacol. 2015, In press. |
R834796C003 (2016) |
not available |
Presentation | Cardiovascular consequences of immune modification by traffic-related emissions. | None | Campen MJ, McDonald JM, Rosenfeld ME, Lund AK | Campen MJ, McDonald JM, Rosenfeld ME, Lund AK. Cardiovascular consequences of immune modification by traffic-related emissions. Poster presented at the Clean Air Research Centers Annual Meeting, Boston, MA, June 21-22, 2012. |
R834796 (2013) R834796 (2015) R834796C003 (2012) R834796C003 (2016) R834796C003 (Final) |
not available |
Presentation | Cardiovascular consequences of immune modification by traffic-related emissions. | None | Campen MJ, McDonald JM, Rosenfeld ME, Lund AK | Campen MJ, McDonald JM, Rosenfeld ME, Lund AK. Cardiovascular consequences of immune modification by traffic-related emissions. Poster presented at the Clean Air Research Centers Annual Meeting, Boston, MA, June 21-22, 2012. |
R834796 (2012) R834796 (Final) R834796C003 (2013) |
not available |
Presentation | Circulatory mechanisms underlying the systemic effects of inhaled nanoparticles and complex combustion mixtures: common pathways for diverse toxicants. | None | Campen MJ | Campen MJ. Circulatory mechanisms underlying the systemic effects of inhaled nanoparticles and complex combustion mixtures:common pathways for diverse toxicants. Presented at the Society of Toxicology (SOT) 56th Annual Meeting & ToxExpo, Baltimore, MD, March 12-16, 2017. |
R834796 (2016) R834796 (Final) R834796C003 (Final) |
not available |
Presentation | Endothelial cell pattern recognition receptors, CD36 and LOX-1, contribute to responses to pollution-induced circulating factors. | None | Campen M | Campen M. Endothelial cell pattern recognition receptors, CD36 and LOX-1, contribute to responses to pollution-induced circulating factors. Presented at the Role of Circulating Factors in Mediating Systemic Toxicity of Inhaled Substances Symposium, Society of Toxicology (SOT) 53rd Annual Meeting & ToxExpo, Phoenix, AZ, March 23-27, 2014. |
R834796 (2014) R834796 (2015) R834796 (Final) R834796C003 (2015) R834796C003 (2016) R834796C003 (Final) |
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Presentation | Woodsmoke exposure alters serum composition that induces inflammatory gene expression and impairs ex vivo wound healing. | None | Campen M, Heine L, Liu J, Brower J, Herbert G, Sanchez B, Zychowski K, Topper L, Doyle-Eisele M, McDonald J | Campen M, Heine L, Liu J, Brower J, Herbert G, Sanchez B, Zychowski K, Topper L, Doyle-Eisele M, McDonald J. Woodsmoke exposure alters serum composition that induces inflammatory gene expression and impairs ex vivo wound healing. Poster presented at the Society of Toxicology (SOT) 55th Annual Meeting & ToxExpo, New Orleans, LA, March 13-17, 2016. |
R834796 (Final) R834796C003 (2016) R834796C003 (Final) |
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Presentation | Serum-borne vascular toxicity following inhalation of mixed engine emissions and treated particles. | None | Liu J, Brower J, Doyle-Eisele M, Herbert G, Heine L, Sanchez B, Zychowski K, Topper L, McDonald J, Campen M | Liu J, Brower J, Doyle-Eisele M, Herbert G, Heine L, Sanchez B, Zychowski K, Topper L, McDonald J, Campen M. Serum-borne vascular toxicity following inhalation of mixed engine emissions and treated particles. Poster presented at the Society of Toxicology (SOT) 55th Annual Meeting & ToxExpo, New Orleans, LA, March 13-17, 2016. |
R834796 (Final) R834796C003 (2016) R834796C003 (Final) |
not available |
Presentation | Competitive receptor-binding assays of 111In-DANBIRT targeting of Luekocyte-function associated antigen-1 in a systemic inflammation rat model to inhaled ozone exposure. | None | Mota RI, Norenberg JP, Daniels T, Lucas S, Campen M | Mota RI, Norenberg JP, Daniels T, Lucas S, Campen M. Competitive receptor-binding assays of 111In-DANBIRT targeting of Luekocyte-function associated antigen-1 in a systemic inflammation rat model to inhaled ozone exposure. Poster presented at the Society of Nuclear Medicine and Molecular Imagine Annual Meeting, San Diego, CA, June 11-13, 2016. |
R834796 (Final) R834796C003 (2016) R834796C003 (Final) |
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Presentation | Liver transcriptomic and metabolic reprogramming after exposure to diesel exhaust. | None | Ramanathan G, Zhao Y, Yin F, Rosenfeld ME, Yang X, Araujo JA | Ramanathan G, Zhao Y, Yin F, Rosenfeld ME, Yang X, Araujo JA. Liver transcriptomic and metabolic reprogramming after exposure to diesel exhaust. Poster presented at the Society of Toxicology (SOT) 55th Annual Meeting & ToxExpo, New Orleans, LA, March 13-17, 2016. |
R834796 (Final) R834796C003 (2016) R834796C003 (Final) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.