Grantee Research Project Results
Publications Details for Grant Number R833338
Internalization and Fate of Individual Manufactured Nanomaterial within Living Cells
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Reference Type | Citation | Progress Report Year | Document Sources |
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Book Chapter | Orr G. Organelle-specific pharmaceutical nanotechnology: active cellular transport of submicro- and nanoscale particles. In: Weissig V, D’Souza GGM, eds. Organelle-Specific Pharmaceutical Nanotechnology. Hoboken, NJ: John Wiley & Sons, 2010, Chapter 19, pp.337-357. |
R833338 (Final) |
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Journal Article | Orr GA, Chrisler WB, Cassens KJ, Tan R, Tarasevich BJ, Markillie LM, Zangar RC, Thrall BD. Cellular recognition and trafficking of amorphous silica nanoparticles by macrophage scavenger receptor A. Nanotoxicology 2011;5(3):296-311. |
R833338 (Final) |
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Journal Article | Orr G, Panther DJ, Phillips JL, Tarasevich BJ, Dohnalkova A, Hu D, Teeguarden JG, Pounds JG. Submicrometer and nanoscale inorganic particles exploit the actin machinery to be propelled along microvilli-like structures into alveolar cells. ACS Nano 2007;1(5):463-475. |
R833338 (2008) R833338 (Final) |
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Journal Article | Orr G, Panther DJ, Cassens KJ, Phillips JL, Tarasevich BJ, Pounds JG. Syndecan-1 mediates the coupling of positively charged submicrometer amorphous silica particles with actin filaments across the alveolar epithelial cell membrane. Toxicology and Applied Pharmacology 2009;236(2):210-220. |
R833338 (2008) R833338 (Final) |
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Presentation | Orr G, Panther DJ, Phillips JL, Tarasevich BJ, Teeguarden JG, Pounds JG. Size and surface properties determine the internalization pathways of nanoparticles by type ii alveolar epithelial cells. Presented at the Society of Toxicology 46th Annual Meeting, Charlotte, NC, March 26, 2007. |
R833338 (2008) R833338 (Final) |
not available |
Presentation | Orr G. Cellular and subcellular interactions with nanoparticles. Presented at the American Chemical Society 236th National Meeting, Philadelphia, PA, August 17-21, 2008. |
R833338 (2008) R833338 (Final) |
not available |
Presentation | Orr G. Nanoparticle-cell interactions and intracellular fate: roles of particle surface properties. Presented at the 3rd Annual Greener Nano Conference, Corvallis, OR, March 10-12, 2008. |
R833338 (2008) R833338 (Final) |
not available |
Presentation | Orr G, Panther DJ, Newell JL, Tarasevich BJ, Pounds JG. Nanomaterial with a specific set of properties can enter the cell via multiple pathways. Presented at the Society of Toxicology 47th Annual Meeting, Seattle, WA, March 16-20, 2008. |
R833338 (2008) R833338 (Final) |
not available |
Presentation | Orr G. Size-and surface-dependent cellular interactions and fate of submicrometer and nanoscale particles. Presented at the 5th Annual Micro Nano Breakthrough Conference, Vancouver, WA, September 8-10, 2008. |
R833338 (2008) R833338 (Final) |
not available |
Presentation | Orr G. Role of particle surface charge in cellular interactions and internalization pathways. Presented at the 4th Annual Greener Nano Conference, Eugene, OR, March 1-2, 2009. |
R833338 (2008) R833338 (Final) |
not available |
Presentation | Orr G, Chrisler WB, Cassens KJ, Tan R, Tarasevich BJ, Markillie LM, Zangar RC, Thrall BD. Cellular recognition and trafficking of anionic nanoparticles by macrophage scavenger receptor A. Presented at The Society of Toxicology 49th Annual Meeting, Salt Lake City, UT, March 7-11, 2010. |
R833338 (Final) |
not available |
Presentation | Williams NG, Tolic A, Chrisler WB, Xie Y, Orr G. Comparative assessment of respiratory epithelial cells responses to engineered nanomaterials. Presented at the 5th Annual Greener Nano Conference, Portland, OR, June 16-18, 2010. |
R833338 (Final) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.