Grantee Research Project Results
Publications Details for Grant Number R832735
Biomarkers Of Health Risks Associated With Environmental Exposure To Arsenic
RFA:
Early Indicators of Environmentally Induced Disease (2004)
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| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
|---|---|---|---|---|---|---|
| Journal Article | Exposure to arsenic in drinking water is associated with increased prevalence of diabetes: a cross-sectional study in the Zimapan and Lagunera regions in Mexico. | ENVIRONMENTAL HEALTH | Del Razo LM, Garcia-Vargas GG, Valenzuela OL, Castellanos EH, Sanchez-Pena LC, Currier JM, Drobna Z, Loomis D, Styblo M | Del Razo LM, Garcia-Vargas GG, Valenzuela OL, Castellanos EH, Sanchez-Pena LC, Currier JM, Drobna Z, Loomis D, Styblo M. Exposure to arsenic in drinking water is associated with increased prevalence of diabetes: a cross-sectional study in the Zimapan and Lagunera regions in Mexico. Environmental Health 2011;10:73. |
R832735 (Final) |
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| Journal Article | Environmental exposure to arsenic, AS3MT polymorphism and prevalence of diabetes in Mexico. | JOURNAL OF EXPOSURE SCIENCE & ENVIRONMENTAL EPIDEMIOLOGY | Drobna Z, Del Razo LM, Garcia-Vargas GG, Sanchez-Pena LC, Barrera-Hernandez A, Styblo M, Loomis D | Drobna Z, Del Razo LM, Garcia-Vargas GG, Sanchez-Pena LC, Barrera-Hernandez A, Styblo M, Loomis D. Environmental exposure to arsenic, AS3MT polymorphism and prevalence of diabetes in Mexico. Journal of Exposure Science & Environmental Epidemiology 2013;23(2):151-155. |
R832735 (Final) |
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| Journal Article | Identification of the GST-T1 and GST-M1 Null Genotypes Using High Resolution Melting Analysis. | CHEMICAL RESEARCH IN TOXICOLOGY | Drobná Z, Del Razo LM, Garcia-Vargas G, Sánchez-Ramírez B, González-Horta C, Ballinas-Casarrubias L, Loomis D, Stýblo M | Drobná Z, Del Razo LM, Garcia-Vargas G, Sánchez-Ramírez B, González-Horta C, Ballinas-Casarrubias L, Loomis D, Stýblo M. Identification of the GST-T1 and GST-M1 Null Genotypes Using High Resolution Melting Analysis. Chemical Research in Toxicology 2012;25(1):216-224. |
R832735 (Final) |
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| Journal Article | Speciation of arsenic in exfoliated urinary bladder epithelial cells from individuals exposed to arsenic in drinking water. | ENVIRONMENTAL HEALTH PERSPECTIVES | Hernandez-Zavala A, Valenzuela OL, Matousek T, Drobna Z, Dedina J, Garcia-Vargas GG, Thomas DJ, Del Razo LM, Styblo M | Hernandez-Zavala A, Valenzuela OL, Matousek T, Drobna Z, Dedina J, Garcia-Vargas GG, Thomas DJ, Del Razo LM, Styblo M. Speciation of arsenic in exfoliated urinary bladder epithelial cells from individuals exposed to arsenic in drinking water. Environmental Health Perspectives 2008;116(12):1656-1660. |
R832735 (2007) R832735 (2008) R832735 (Final) |
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| Journal Article | Speciation analysis of arsenic in biological matrices by automated hydride generation-cryotrapping-atomic absorption spectrometry with multiple microflame quartz tube atomizer (multiatomizer). | JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY | Hernandez-Zavala A, Matousek T, Drobna Z, Paul DS, Walton F, Adair BM, Dedina J, Thomas DJ, Styblo M | Hernandez-Zavala A, Matousek T, Drobna Z, Paul DS, Walton F, Adair BM, Dedina J, Thomas DJ, Styblo M. Speciation analysis of arsenic in biological matrices by automated hydride generation-cryotrapping-atomic absorption spectrometry with multiple microflame quartz tube atomizer (multiatomizer). Journal of Analytical Atomic Spectrometry 2008;23(3):342-351. |
R832735 (2006) R832735 (2007) R832735 (2008) R832735 (Final) |
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| Journal Article | Expression of AS3MT alters transcriptional profiles in human urothelial cells exposed to arsenite | None | Hester SD, Drobna Z, Andrews DMK, Liu J, Waalkes MP, Thomas DJ, Styblo M | Hester SD, Drobna Z, Andrews DMK, Liu J, Waalkes MP, Thomas DJ, Styblo M. Expression of AS3MT alters transcriptional profiles in human urothelial cells exposed to arsenite. Human & Experimental Toxicology 2009;28(1):49-61. |
R832735 (2008) |
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| Journal Article | Oxidation state specific generation of arsines from methylated arsenicals based on L-cysteine treatment in buffered media for speciation analysis by hydride generation-automated cryotrapping-gas chromatography-atomic absorption spectrometry with the multiatomizer. | SPECTROCHIMICA ACTA PART B: ATOMIC SPECTROSCOPY | Matousek T, Hernandez-Zavala A, Svoboda M, Langrova L, Adair BM, Drobna Z, Thomas DJ, Styblo M, Dedina J | Matousek T, Hernandez-Zavala A, Svoboda M, Langrova L, Adair BM, Drobna Z, Thomas DJ, Styblo M, Dedina J. Oxidation state specific generation of arsines from methylated arsenicals based on L-cysteine treatment in buffered media for speciation analysis by hydride generation-automated cryotrapping-gas chromatography-atomic absorption spectrometry with the multiatomizer. Spectrochimica Acta Part B: Atomic Spectroscopy 2008;63(3):396-406. |
R832735 (2007) R832735 (Final) |
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| Journal Article | Epigenetic Changes in Individuals with Arsenicosis. | CHEMICAL RESEARCH IN TOXICOLOGY | Smeester L, Rager JE, Bailey KA, Guan X, Smith N, García-Vargas G, Del Razo L-M, Drobná Z, Kelkar H, Stýblo M, Fry RC | Smeester L, Rager JE, Bailey KA, Guan X, Smith N, García-Vargas G, Del Razo L-M, Drobná Z, Kelkar H, Stýblo M, Fry RC. Epigenetic Changes in Individuals with Arsenicosis. Chemical Research in Toxicology 2011;24(2):165-167. |
R832735 (Final) |
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| Journal Article | Association of AS3MT polymorphisms and the risk of premalignant arsenic skin lesions. | TOXICOLOGY AND APPLIED PHARMACOLOGY | Valenzuela OL, Drobna Z, Hernandez-Castellanos E, Sanchez-Pena LC, Garcia-Vargas GG, Borja-Aburto VH, Styblo M, Del Razo LM | Valenzuela OL, Drobna Z, Hernandez-Castellanos E, Sanchez-Pena LC, Garcia-Vargas GG, Borja-Aburto VH, Styblo M, Del Razo LM. Association of AS3MT polymorphisms and the risk of premalignant arsenic skin lesions. Toxicology and Applied Pharmacology 2009;239(2):200-207. |
R832735 (Final) |
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| Presentation | As speciation by cryofocusing-new approaches to atomization for atomic absorption and atomic fluorescence. | None | Dedina J, Matousek T, Svoboda M, Styblo M, Devesa V | Dedina J, Matousek T, Svoboda M, Styblo M, Devesa V. As speciation by cryofocusing-new approaches to atomization for atomic absorption and atomic fluorescence. Presented at the 6th International Symposium on Speciation of Elements in Biological, Environmental and Toxicological Sciences (ISSEBETS), Bialoweza, Poland, June 2006. |
R832735 (Final) |
not available |
| Presentation | Speciation of arsenic in biological matrices by automated HG-AAS with multiple microflame quartz tube atomizer (multiatomizer). | None | Hernandez-Zavala A, Drobna Z, Valenzuela O, Del Razo LM, Adair B, Matousek T, Dedina J, Thomas DJ, Styblo M | Hernandez-Zavala A, Drobna Z, Valenzuela O, Del Razo LM, Adair B, Matousek T, Dedina J, Thomas DJ, Styblo M. Speciation of arsenic in biological matrices by automated HG-AAS with multiple microflame quartz tube atomizer (multiatomizer). Presented at the Society of Toxicology 46th Annual Meeting, Charlotte, NC, March 2007. |
R832735 (2006) R832735 (2007) R832735 (Final) |
not available |
| Presentation | Dimethylarsinite in urine is a predictor of risk of diabetes associated with chronic exposure to inorganic arsenic. | None | Loomis D, Del Razo LM, Garcia-Vargas G, Drobna Z, Styblo M | Loomis D, Del Razo LM, Garcia-Vargas G, Drobna Z, Styblo M. Dimethylarsinite in urine is a predictor of risk of diabetes associated with chronic exposure to inorganic arsenic. Presented at the Society of Toxicology 49th Annual Meeting & Tox Expo, Salt Lake City, UT, March 7-11, 2010. |
R832735 (Final) |
not available |
| Presentation | Application of selective hydride generation-automated cryotrapping-gas chromatography-AAS to speciation analysis of methylated arsenicals in water and cell cultures at sub-ppb levels. | None | Matousek T, Saunders RJ, Walton FS, Svoboda M, Styblo M, Dedina J | Matousek T, Saunders RJ, Walton FS, Svoboda M, Styblo M, Dedina J. Application of selective hydride generation-automated cryotrapping-gas chromatography-AAS to speciation analysis of methylated arsenicals in water and cell cultures at sub-ppb levels. Presented at the 7th International Symposium on Speciation of Elements in Biological, Environmental and Toxicological Sciences (ISSEBETS), Eger, Hungary, August 28, 2009. |
R832735 (Final) |
not available |
| Presentation | Insulin signaling, arsenic and the pathogenesis of diabetes. | None | Styblo M, Del Razo LM, Garcia-Vargas GG, Drobna Z, Ethan L | Styblo M, Del Razo LM, Garcia-Vargas GG, Drobna Z, Ethan L. Insulin signaling, arsenic and the pathogenesis of diabetes. Presented at the International Workshop on Research and Risk Assessment for Arsenic (sponsored by U.S. EPA), National Conservation Training Center, Shepherdstown, WV, May 31-June 2, 2006. |
R832735 (Final) |
not available |
| Presentation | Environmental arsenic and diabetes. | None | Styblo M, Del Razo LM, Garcia-Vargas GG, Drobna Z, Ethan L | Styblo M, Del Razo LM, Garcia-Vargas GG, Drobna Z, Ethan L. Environmental arsenic and diabetes. Presented at the NIEHS/U.S. EPA Future Research on Endocrine Disruption: Translation of Basic and Animal Research to Understand Human Disease Conference, Durham, NC, August 27-29, 2007. |
R832735 (Final) |
not available |
| Presentation | Environmental arsenic as a disruptor of insulin signaling. | None | Styblo M, Del Razo LM, Garcia-Vargas GG, Drobna Z, Ethan L | Styblo M, Del Razo LM, Garcia-Vargas GG, Drobna Z, Ethan L. Environmental arsenic as a disruptor of insulin signaling. Presented at the 10th International Symposium on Metal Ions in Biology and Medicine, Bastia, Corsica, France, May 19-22, 2008. |
R832735 (Final) |
not available |
| Presentation | Environmental arsenic and diabetes mellitus. | None | Styblo M, Del Razo LM, Garcia-Vargas GG, Drobna Z, Ethan L | Styblo M, Del Razo LM, Garcia-Vargas GG, Drobna Z, Ethan L. Environmental arsenic and diabetes mellitus. Presented at the Tópicos Selectos de Toxicología, Universidad Autónoma del Estado de Hidalgo, Pachuca, Mexico, November 3, 2008. |
R832735 (Final) |
not available |
| Presentation | Relationship between arsenic-skin lesions and the Met287Thr polymorphism in AS3MT gene. | None | Valenzuela OL, Drobna Z, Garcia-Vargas GG, Borja-Aburto VH, Styblo M, Del Razo LM | Valenzuela OL, Drobna Z, Garcia-Vargas GG, Borja-Aburto VH, Styblo M, Del Razo LM. Relationship between arsenic-skin lesions and the Met287Thr polymorphism in AS3MT gene. Presented at the Society of Toxicology 47th Annual Meeting, Seattle, WA, March 16-20, 2008. |
R832735 (Final) |
not available |
| Presentation | Arsenic (+3 oxidation state) methyltransferase (AS3MT) polymorphism as a marker of susceptibility to chronic toxicity of arsenic. | None | Valenzuela OL, Drobna Z, Garcia-Vargas GG, Borja-Aburto VH, Styblo M, Del Razo LM | Valenzuela OL, Drobna Z, Garcia-Vargas GG, Borja-Aburto VH, Styblo M, Del Razo LM. Arsenic (+3 oxidation state) methyltransferase (AS3MT) polymorphism as a marker of susceptibility to chronic toxicity of arsenic. Presented at the 2nd International Congress: Arsenic in the Environment, Valencia, Spain, May 2008. |
R832735 (Final) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.