Grantee Research Project Results
Publications Details for Grant Number R825358
Improving Methods for Identifying Noncancer Risks Application of Cell Kinetic Models for Methylmercury Risk Assessment
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Reference Type | Citation | Progress Report Year | Document Sources |
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Abstract | Lewandowski TA, Bartell SM, Pierce CH, Ponce RA, Faustman EM. Effect of tissue binding uncertainty on a PBTK model of methylmercury in the fetal rat. Toxicology Letters 1998;95(Suppl 1):130. |
R825358 (Final) |
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Abstract | Lewandowski TA, Bartell SM, Pierce CH, Ponce RA, Faustman EM. Toxicokinetic and toxicodynamic modeling of the effects of methylmercury on the fetal rat. The Toxicologist 1998;42:139. |
R825173 (1999) R825358 (Final) |
not available |
Abstract | Lewandowski TA, Ponce RA, Hong S, Bartell SM, Faustman EM. Biologically-based dose-response model for methylmercury developmental toxicity incorporating novel in vivo cell cycling data. The Toxicologist 2000;54:1370. |
R825358 (Final) |
not available |
Abstract | Lewandowski TA, Schroeder JL, Ponce RA, Bartell SM, Faustman EM. In vivo determination of cell cycling rates in embryonic rat neural cells:development of a biologically-based toxicodynamic model for methylmercury risk assessment. The Toxicologist 1999. |
R825358 (Final) |
not available |
Abstract | Lu S, Kavanagh TJ, Faustman EM. Methylmercury's effects on mitochondrial DNA in developing rodent midbrain. The Toxicologist 2000;54:162. |
R825358 (Final) |
not available |
Abstract | McMillan MJ, Ponce RA, Kirchner SC, Hunt KA, Hong S, Ou YC, Faustman EM. Cell cycle phase-specific expression of cell cycle regulatory genes in rodent embryonic neuroepithelial cells exposed to methylmercury. Teratology 1998;57:225. |
R825358 (Final) |
not available |
Abstract | Mendoza MA, Ponce RA, Ou YC, Faustman EM. Involvement of p21WAF1/CIP1 in methlymercury induced cell cycle inhibition. The Toxicologist 2000;54:238. |
R825358 (Final) |
not available |
Abstract | Mendoza MAC, Ou YC, Hong S, Faustman EM. A p53 independent methyl mercury-induced G2/M arrest. The Toxicologist 1999;48:282. |
R825358 (Final) |
not available |
Abstract | Ou YC, Lu S, Faustman EM. Induction of necrotic and apoptotic cell death following methylmercyr (MeHg) exposure in primary embryonic CNS cells. The Toxicologist 1998;42(1-S):196. |
R825358 (Final) |
not available |
Abstract | Ponce RA, Bartell SM, Sanga RN, Faustman EM. Comparative analyses of exposure estimates based on biomarkers or predictive models: a case example with dietary methylmercury intake. Toxicology Letters 1998;95(Suppl 1):131-132. |
R825358 (Final) |
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Book Chapter | Lewandowski TA, Ponce RA, Whittaker SG, Faustman EM. In vitro models for evaluating developmental toxicity. In: Gad SC, ed. In Vitro Toxicology. New York, NY: Taylor & Francis, 2000, Chapter 8, pp. 139-185. |
R825358 (Final) |
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Journal Article | Lewandowski TA, Pierce CH, Pingree SD, Hong S, Faustman EM. Methylmercury distribution in the pregnant rat and embryo during early midbrain organogenesis. Teratology 2002;66(5):235-241. |
R825358 (Final) R826886 (2000) |
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Journal Article | Lewandowski TA, Ponce RA, Charleston JS, Hong S, Faustman EM. Effect of methylmercury on midbrain cell proliferation during organogenesis: potential cross-species differences and implications for risk assessment. Toxicological Sciences 2003;75(1):124-133. |
R825358 (Final) |
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Journal Article | Mendoza MAC, Ponce RA, Ou YC, Faustman EM. p21WAF1/CIP1 inhibits cell cycle progression but not G2/M-phase transition following methylmercury exposure. Toxicology and Applied Pharmacology 2002;178(2):117-125. |
R825358 (Final) R826886 (2000) |
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Journal Article | Ou YC, Thompson SA, Ponce RA, Schroeder J, Kavanagh TJ, Faustman EM. Induction of the cell cycle regulatory gene p21 (Waf1, Cip1) following methylmercury exposure in vitro and in vivo. Toxicology and Applied Pharmacology 1999;157(3):203-212. |
R825358 (Final) R826886 (2000) |
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Journal Article | Ou YC, White CC, Krejsa CM, Ponce RA, Kavanagh TJ, Faustman EM. The role of intracellular glutathione in methylmercury-induced toxicity in embryonic neuronal cells. NeuroToxicology 1999;20(5):793-804. |
R825358 (Final) R826886 (2000) |
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Paper | Lewandowski TA, Bartell SM, Ponce RA, Faustman EM. Linking mechanism-based toxicokinetic and toxicodynamic models for neurodevelopmental toxicity. |
R825358 (Final) |
not available |
Paper | Lewandowski TA, Bartell SM, Ponce RA, Faustman EM. Use of physiological and toxicological data in a biologically-based model of methylmercury developmental toxicity. |
R825358 (Final) |
not available |
Presentation | Bartell SM, Ponce RA, Sanga RN, Faustman EM. Human variability in steady state blood-to-hair, blood-to-intake, and hair-to-intake ratios for mercury: implications for health risk assessment. Presented at the Fifth International Conference on Mercury as a Global Pollutant, Rio de Janeiro, Brazil, May 23-27 1999. |
R825358 (Final) |
not available |
Presentation | Lewandowski TA, Ponce RA, Hong S, Bartell SM, Faustman EM. Biologically-based dose-response model for methylmercury developmental toxicity incorporating novel in vivo cell cycling data. Presented to the Society of Toxicology, Philadelphia, PA, 2000. |
R825358 (Final) |
not available |
Presentation | Lewandowski TA, Bartell SM, Pierce CH, Ponce RA, Faustman EM. Effect of tissue binding uncertainty on a PBTK model of methylmercury in the fetal rat. Presented at the International Union of Toxicology Meeting, Paris, France, 1998. |
R825358 (Final) |
not available |
Presentation | Lewandowski TA, Schroeder JL, Ponce RA, Bartell SM, Faustman EM. In vivo determination of cell cycling rates in embryonic rat neural cells: development of a biologically-based toxicodynamic model for methylmercury risk assessment. Presented at the Society of Toxicology Annual Meeting, New Orleans, LA, 1999. |
R825358 (Final) |
not available |
Presentation | Lewandowski TA, Hong SW, Pingree S, Pierce CH, Ponce RA, Faustman EM. Methylmercury distribution in pregnant rats and their fetuses during early organogenesis. Presented to the Teratology Society, Keystone, CO, 1999. |
R825358 (Final) |
not available |
Presentation | Lewandowski TA, Bartell SM, Pierce CH, Ponce RA, Faustman EM. PBTK model of methylmercury toxicity in the fetal rat. Presented at the Society of Risk Analysis Annual Meeting, Pheonix, AZ, December 1998. |
R825358 (Final) |
not available |
Presentation | Lewandowski TA, Bartell SM, Pierce CH, Ponce RA, Faustman EM. Toxicokinetic and toxicodynamic modeling of the effects of methylmercury on the fetal rat. Presented at the Society of Toxicology Annual Meeting, Seattle, WA, 1998. |
R825358 (Final) |
not available |
Presentation | Lu SJ, McMillan MJ, Kirchner SC, Ou YC, Faustman EM. Mechanisms of methylmercury-induced cell cycle arrest and cell death in primary embryonic cells. Presented to the Congress of the International Union of Toxicology, Paris, France, July 1998. |
R825358 (Final) |
not available |
Presentation | Lu S, Kavanagh TJ, Faustman EM. Methlymercury's effects on mitochondrial DNA in developing rodent midbrain. Presented at the Society of Toxicology Annual Meeting, Philadelphia, PA, 2000. |
R825358 (Final) |
not available |
Presentation | McMillan MJ, Ponce RA, Kirchner SC, Hunt KA, Hong S, Ou YC, Faustman EM. Cell cycle phase-specific expression of cell cycle regulatory genes in rodent embryonic neuroepithelial cells exposed to methylmercury. Presented at the Teratology Society Annual Meeting, San Diego, CA, 1998. |
R825358 (Final) |
not available |
Presentation | Mendoza MA, Ponce RA, Ou YC, Faustman EM. Involvement of p21WAF1/CIP1 in methlymercury induced cell cycle inhibition. Presented at the Society of Toxicology Annual Meeting, Philadelphia, PA, 2000. |
R825358 (Final) |
not available |
Presentation | Mendoza MAC, Ou YC, Hong S, Faustman EM. A p53 independent methyl mercury-induced G2/M arrest. Presented at the Society of Toxicology Annual Meeting, New Orleans, LA, 1999. |
R825358 (Final) |
not available |
Presentation | Ponce RA, Bartell SM, Sanga RN, Faustman EM. Comparative analyses of exposure estimates based on biomarkers or predictive models: a case example with dietary methylmercury intake. Presented at the International Union of Toxicology Meeting, Paris, France, 1998. |
R825358 (Final) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.