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Abstract (2)
Journal Article (3)
Presentation (26)
Reference Type Reference Title Journal Author Citation Progress Report Year Document Sources
Abstract Fluorescence in situ hybridization techniques FISH to detect changes in CYP19a gene expression of Japanese medaka Oryzias latipes TOXICOLOGY AND APPLIED PHARMACOLOGY Park J, Tompsett A, Zhang X, Newstead J, Jones P, Au D, kong R, Wu R, Giessy J, Hecker M Park J, Tompsett A, Zhang X, Newstead J, Jones P, Au D, kong R, Wu R, Giessy J, Hecker M. Fluorescence in situ hybridization techniques FISH to detect changes in CYP19a gene expression of Japanese medaka Oryzias latipes. TOXICOLOGY AND APPLIED PHARMACOLOGY 2008;232(2):226-235. R831846 (Final)
Abstract Responses of the medaka HPG axis PCR array and reproduction to prochloraz and ketoconazole ENVIRONMENTAL SCIENCE & TECHNOLOGY Zhang X, Hecker M, Jones P, Newstead J, Au D, Kong R, Wu R, Giessy J Zhang X, Hecker M, Jones P, Newstead J, Au D, Kong R, Wu R, Giessy J. Responses of the medaka HPG axis PCR array and reproduction to prochloraz and ketoconazole. ENVIRONMENTAL SCIENCE & TECHNOLOGY 2008;42(17):6762-6769 R831846 (Final)
Journal Article Advanced fluorescence in situ hybridization to localize and quantify gene expression in Japanese medaka (Oryzias latipes) exposed to endocrine-disrupting compounds. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY Park JW, Tompsett AR, Zhang X, Newsted JL, Jones PD, Au DW, Kong R, Wu RS, Giesy JP, Hecker M Park JW, Tompsett AR, Zhang X, Newsted JL, Jones PD, Au DW, Kong R, Wu RS, Giesy JP, Hecker M. Advanced fluorescence in situ hybridization to localize and quantify gene expression in Japanese medaka (Oryzias latipes) exposed to endocrine-disrupting compounds. Environmental Toxicology and Chemistry 2009;28(9):1951-1962. R831846 (Final)
Journal Article In situ hybridization to detect spatial gene expression in medaka. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY Tompsett AR, Park JW, Zhang X, Jones PD, Newsted JL, Au DWT, Chen EXH, Yu R, Wu RSS, Kong RYC, Giesy JP, Hecker M Tompsett AR, Park JW, Zhang X, Jones PD, Newsted JL, Au DWT, Chen EXH, Yu R, Wu RSS, Kong RYC, Giesy JP, Hecker M. In situ hybridization to detect spatial gene expression in medaka. Ecotoxicology and Environmental Safety 2009;72(4):1257-1264. R831846 (Final)
Journal Article Real-time PCR array to study effects of chemicals on the Hypothalamic-Pituitary-Gonadal axis of the Japanese medaka. AQUATIC TOXICOLOGY Zhang X, Hecker M, Park JW, Tompsett AR, Newsted J, Nakayama K, Jones PD, Au D, Kong R, Wu RS, Giesy JP Zhang X, Hecker M, Park JW, Tompsett AR, Newsted J, Nakayama K, Jones PD, Au D, Kong R, Wu RS, Giesy JP. Real-time PCR array to study effects of chemicals on the Hypothalamic-Pituitary-Gonadal axis of the Japanese medaka. Aquatic Toxicology 2008;88(3):173-182. R831846 (Final)
Presentation PCDDs and PCDFs in Small Mammals Foraging in the Tittabawassee River Floodplain, Michigan. None Coefield S.J. , Zwiernik M.J. , Seston R.M. , Fredricks T.B. , Moore J.N. , Tazelaar D. , Kay D.L. , Jones P.D. , Bradley P. , Giesy J.P. S.J. Coefield, M.J. Zwiernik, R.M. Seston, T.B. Fredricks, J.N. Moore, D. Tazelaar, D.L. Kay, P.D. Jones, P. Bradley and J.P. Giesy. PCDDs and PCDFs in Small Mammals Foraging in the Tittabawassee River Floodplain, Michigan. To: 26th Annual Meeting, November 13-17, 2005, Baltimore MD. R831846 (2005)
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Presentation Site-specific Dietary Exposure Assessment of Several Passerine Bird Species to PCDDs and PCDFs. None Fredricks T.B. , Zwiernik M.J. , Coefield S.J. , Seston R.M. , Moore J.N. , Tazelaar D.L. , White T.C. , Kay D.P. , Giesy J.P. T.B. Fredricks, M.J. Zwiernik, S.J. Coefield, R.M. Seston, J.N. Moore, D.L. Tazelaar, T.C. White, D.P. Kay and J.P. Giesy. Site-specific Dietary Exposure Assessment of Several Passerine Bird Species to PCDDs and PCDFs. To: 26th Annual Meeting, November 13-17, 2005, Baltimore MD. R831846 (2005)
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Presentation Monitoring of Exposure to and Potential Effects of Contaminants in the Environment. None Giesy J.P. , Depledge M.H. , Lam P.K.S., Wu R.S.S. J.P. Giesy, M.H. Depledge, P.K.S. Lam and R.S.S. Wu. Monitoring of Exposure to and Potential Effects of Contaminants in the Environment. To: 26th Annual Meeting, November 13-17, 2005, Baltimore MD R831846 (2005)
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Presentation Effects of Pharmaceuticals on Gene Expression and Hormone Production in H295R Cell Line Using Q-RT-PCR/ELISA. None Gracia T, Jones P.D. , Hilscherova K. , Higley K. , Newsted J.L., Giesy J.P. . T. Gracia, P.D. Jones, K. Hilscherova, K. Higley, J.L. Newsted and J.P. Giesy. Effects of Pharmaceuticals on Gene Expression and Hormone Production in H295R Cell Line Using Q-RT-PCR/ELISA. To: 26th Annual Meeting, November 13-17, 2005, Baltimore MD. R831846 (2005)
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Presentation Chemical induced changes in gene expression patterns along the HPG-axis at different organizational levels using a small animal model (Japanese medaka). None Hecker M, Tompsett AR, Park JW, Jones PD, Newsted JL, Giesy JP Hecker M, Tompsett AR, Park JW, Jones PD, Newsted JL, Giesy JP. Chemical induced changes in gene expression patterns along the HPG-axis at different organizational levels using a small animal model (Japanese medaka). Presented at the Computational Toxicology Workshop, June 2006. R831846 (2006)
R831846 (Final)
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Presentation Spatial and Temporal Distributions of Polycyclic Aromatic Hydrocarbons in Sediments from Michigan Inland Lakes. None Kannan K. , Johnson B. , Yohn S.S. , Giesy J.P. , Long D.T. K. Kannan, B. Johnson, S.S. Yohn, J.P. Giesy and D.T. Long. Spatial and Temporal Distributions of Polycyclic Aromatic Hydrocarbons in Sediments from Michigan Inland Lakes. To: 26th Annual Meeting, November 13-17, 2005, Baltimore MD. R831846 (2005)
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Presentation PCDDs and PCDFs in Aquatic and Terrestrial Food Webs of the Tittabawasee River, Michigan. None Kay D.P. , Blankenship A.L. , Zwiernik M.J. , Jones P.D. , Newsted J.L. , Giesy J.P. D.P. Kay, A.L. Blankenship, M.J. Zwiernik, P.D. Jones, J.L. Newsted and J.P. Giesy. PCDDs and PCDFs in Aquatic and Terrestrial Food Webs of the Tittabawasee River, Michigan. To: 26th Annual Meeting, November 13-17, 2005, Baltimore MD. R831846 (2005)
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Presentation Characterization and Distribution of Dioxin-like and Estrogenic Compounds in Sediment from Korean Coasts. None Khim J.-S. , Villeneuve D.L. , Kannan K., Johnson B. , Giesy J.P. , Koh C. J.-S. Khim, D.L. Villeneuve, K. Kannan B. Johnson, J.P. Giesy and C. Koh. Characterization and Distribution of Dioxin-like and Estrogenic Compounds in Sediment from Korean Coasts. To: 26th Annual Meeting, November 13-17, 2005, Baltimore MD. R831846 (2005)
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Presentation Dioxin-like and Estrogenic Compounds and Activities Associated With Marine Sediment from Yeongil Bay, Korea. None Khim J.-S. , Villeneuve D.L. , Kannan K. , Giesy J.P. , Koh C. J.-S. Khim, D.L. Villeneuve, K. Kannan, J.P. Giesy and C. Koh. Dioxin-like and Estrogenic Compounds and Activities Associated With Marine Sediment from Yeongil Bay, Korea. To: 26th Annual Meeting, November 13-17, 2005, Baltimore MD. R831846 (2005)
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Presentation Distribution and Sources of Trace Organic Contaminants in Marine Sediment. None Khim J.-S. , Villeneuve D. , Kannan K. , Giesy J.P. , Koh C. J.-S. Khim, D. Villeneuve, K. Kannan, J.P. Giesy and C. Koh. Distribution and Sources of Trace Organic Contaminants in Marine Sediment. To: 26th Annual Meeting, November 13-17, 2005, Baltimore MD. R831846 (2005)
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Presentation Tissue Residue Concentrations of PCDDs and PCDFs in Megaloptera: A comparison to Other Benthic Invertebrate Orders. None Moore J.N. , Park C.S. , Zwiernik M.J. , Kay D.P. , Tazelaar D.L. , Hamman D.W. , Giesy J.P. J.N. Moore, C.S. Park, M.J. Zwiernik, D.P. Kay, D.L. Tazelaar, D.W. Hamman and J.P. Giesy. Tissue Residue Concentrations of PCDDs and PCDFs in Megaloptera: A comparison to Other Benthic Invertebrate Orders. To: 26th Annual Meeting, November 13-17, 2005, Baltimore, MD. R831846 (2005)
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Presentation Avian Toxicity Reference Values (TRVs) for Perfluorooctane Sulfonate (PFOS). None Newsted J.L , Jones P.D. , Coady K. , Giesy J.P. J.L Newsted, P.D. Jones, K. Coady and J.P. Giesy. Avian Toxicity Reference Values (TRVs) for Perfluorooctane Sulfonate (PFOS). To: 26th Annual Meeting, November 13-17, 2005, Baltimore MD. R831846 (2005)
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Presentation Application of in situ hybridization to detect CYP19-A1 and -A2 aromatase gene expression patterns along the HPG-axis at different organizational levels in Japanese medaka (Oryzias latipes). None Park JW, Tompsett AR, Hecker M, Newsted JL, Jones PD, Giesy JP Park JW, Tompsett AR, Hecker M, Newsted JL, Jones PD, Giesy JP. Application of in situ hybridization to detect CYP19-A1 and-A2 aromatase gene expression patterns along the HPG-axis at different organizational levels in Japanese medaka (Oryzias latipes). Presented at the 26th Annual Society of Environmental Toxicology and Chemistry (SETAC) Meeting, Baltimore MD, November 13-17, 2005. R831846 (2005)
R831846 (2006)
R831846 (Final)
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Presentation mRNA gene expressions of CYP19a and b in juvenile Japanese medaka (Oryzias latipes) exposed to fadrozole: comparison of RT-PCR with ISH methods. None Park JW, Tompsett AR, Hecker M, Jones PD, Newsted JL, Giesy JP Park JW, Tompsett AR, Hecker M, Jones PD, Newsted JL, Giesy JP. mRNA gene expressions of CYP19a and b in juvenile Japanese medaka (Oryzias latipes) exposed to fadrozole:comparison of RT-PCR with ISH methods. Presented at the 27th Annual Meeting of the Society of Environmental Toxicology and Chemistry (SETAC) North America, Montreal, Quebec, November 4-9, 2006. R831846 (Final)
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Presentation Development of fluorescence in situ hybridization techniques to detect and quantify expression profiles of genes along the HPG-axis in Japanese medaka. None Park JW, Tompsett AR, Zhang X, Hecker M, Jones PD, Newsted JL, Giesy JP Park JW, Tompsett AR, Zhang X, Hecker M, Jones PD, Newsted JL, Giesy JP. Development of fluorescence in situ hybridization techniques to detect and quantify expression profiles of genes along the HPG-axis in Japanese medaka. Presented at the 28th Annual Society of Environmental Toxicology and Chemistry (SETAC) North America Meeting, Milwaukee, WI, November 11-15, 2007. R831846 (Final)
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Presentation Assessment of Belted Kingfisher (Ceryle alcyon) Dietary Exposure to PCDDs and PCDFs in the Tittabawassee River, MI. None Seston R.M. , Zwiernik M.J. , Moore J.N. , Tazelaar D.L. , Wong H.L. , Bradley P.W. , Fredricks T.B. , Coefield J.J. , Jones P.D. , Giesy J.P. R.M. Seston, M.J. Zwiernik, J.N. Moore, D.L. Tazelaar, H.L. Wong, P.W. Bradley, T.B. Fredricks, J.J. Coefield, P.D. Jones and J.P. Giesy. Assessment of Belted Kingfisher (Ceryle alcyon) Dietary Exposure to PCDDs and PCDFs in the Tittabawassee River, MI. To: 26th Annual Meeting, November 13-17, 2005, Baltimore MD. R831846 (2005)
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Presentation A Comparison of PCDD and PCDF Bioavailability Among Terrestrial Invertebrates from the Tittabawassee River Floodplain. None Tazelaar D.L. , Kay D.P. , Zwiernik M.J. , Moore J.N. , Hamman D.W. , Blankenship A.L. , Fredricks T.B. , Seston R.M. , Coefield S.J. , Giesy J.P. D.L. Tazelaar, D.P. Kay, M.J. Zwiernik, J.N. Moore, D.W. Hamman, A.L. Blankenship, T.B. Fredricks, R.M. Seston, S.J. Coefield and J.P. Giesy. A Comparison of PCDD and PCDF Bioavailability Among Terrestrial Invertebrates from the Tittabawassee River Floodplain. To: 26th Annual Meeting, November 13-17, 2005, Baltimore MD. R831846 (2005)
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Presentation Chemical induced changes in gene expression patterns along the HPG-axis at different organizational levels using a small animal model (Japanese medaka). None Tompsett AR, Park JW, Hecker M, Jones PD, Newsted JL, Giesy JP Tompsett AR, Park JW, Hecker M, Jones PD, Newsted JL, Giesy JP. Chemical induced changes in gene expression patterns along the HPG-axis at different organizational levels using a small animal model (Japanese medaka). Presented at the Science To Achieve Results (STAR) Computational Toxicology Progress Review Workshop, Research Triangle Park, NC, July 18-19, 2005. R831846 (2005)
R831846 (2006)
R831846 (Final)
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Presentation Application of in situ hybridization techniques to detect CYP19-A1 and -A2 aromatase gene expression patterns along the HPG-axis in Japanese medaka (Oryzias latipes). None Tompsett AR, Park JW, Hecker M, Newsted JL, Jones PD, Giesy JP Tompsett AR, Park JW, Hecker M, Newsted JL, Jones PD, Giesy JP. Application of in situ hybridization techniques to detect CYP19-A1 and-A2 aromatase gene expression patterns along the HPG-axis in Japanese medaka (Oryzias latipes). Presented at the Society of Environmental Toxicology and Chemistry (SETAC) Ohio Valley Chapter Meeting, Fort Wayne, IN, April 20-21, 2006. R831846 (2006)
R831846 (Final)
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Presentation Elucidating changes in aromatase (CYP19) gene expression using in situ hybridization techniques in a whole animal model. None Tompsett AR, Park JW, Hecker M, Jones PD, Newsted JL, Giesy JP Tompsett AR, Park JW, Hecker M, Jones PD, Newsted JL, Giesy JP. Elucidating changes in aromatase (CYP19) gene expression using in situ hybridization techniques in a whole animal model. Presented at the 27th Annual Society of Environmental Toxicology and Chemistry (SETAC) North America Meeting, Montreal, Quebec, November 4-9, 2006. R831846 (Final)
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Presentation Gene expression and histological structure as biomarkers of chemical exposure in Japanese medaka. None Tompsett AR, Park JW, Zhang X, Hecker M, Jones PD, Newsted JL, Au DWT, Giesy JP Tompsett AR, Park JW, Zhang X, Hecker M, Jones PD, Newsted JL, Au DWT, Giesy JP. Gene expression and histological structure as biomarkers of chemical exposure in Japanese medaka. Presented at the 28th Annual Society of Environmental Toxicology and Chemistry (SETAC) North America Meeting, Milwaukee, WI, November 11-15, 2007. R831846 (Final)
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Presentation Separation and Characterization pf Structural Isomers of Perfluorinated Compounds. None Yoo H. , Jones P.D. , Bradley P.W. , Gužviae M. , Upham B.L. , Trosko J.E. , Newsted J.L. , Giesy J.P. H. Yoo, P.D. Jones, P.W. Bradley, M. Gužviae, B.L. Upham, J.E. Trosko, J.L. Newsted and J.P. Giesy. Separation and Characterization pf Structural Isomers of Perfluorinated Compounds. To: 26th Annual Meeting, November 13-17, 2005, Baltimore MD. R831846 (2005)
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Presentation A Comparison of H295R, R2C and JEG-3 Cells as Screening Tools for Effects on Steroidogenesis. None Zhang X., Yu R.M.K. , Jones P.D , Newsted J.L. , Gracia T. , Hecker M. , Wu R.S.S, Giesy J.P. X. Zhang, R.M.K. Yu, P.D Jones, J.L. Newsted, T. Gracia, M. Hecker, R.S.S Wu and J.P. Giesy. A Comparison of H295R, R2C and JEG-3 Cells as Screening Tools for Effects on Steroidogenesis. To: 26th Annual Meeting, November 13-17, 2005, Baltimore MD. R831846 (2005)
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Presentation Development and validation of a quantitative real time RT-PCR system to study chemical induced effects on the HPG-axis of Medaka (Oryzias latipes). None Zhang X, Park J-W, Tompsett AR, Hecker M, Jones PD, Newsted J, Giesy JP Zhang X, Park J-W, Tompsett AR, Hecker M, Jones PD, Newsted J, Giesy JP. Development and validation of a quantitative real time RT-PCR system to study chemical induced effects on the HPG-axis of Medaka (Oryzias latipes). Presented at the 27th Annual Society of Environmental Toxicology and Chemistry (SETAC) North America Meeting, Montreal, Quebec, November 4-9, 2006. R831846 (Final)
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Presentation Testing of five model endocrine disrupting chemicals using Medaka brain-pituitary-gonadal (BHG) axis model and RT-PCR array method. None Zhang X, Tompsett AR, Park J-W, Hecker M, Newsted JL, Jones PD, Giesy JP Zhang X, Tompsett AR, Park J-W, Hecker M, Newsted JL, Jones PD, Giesy JP. Testing of five model endocrine disrupting chemicals using Medaka brain-pituitary-gonadal (BHG) axis model and RT-PCR array method. Presented at the 28th Annual Society of Environmental Toxicology and Chemistry (SETAC) North America Meeting, Milwaukee, WI, November 11-15, 2007. R831846 (Final)
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Presentation Mink and PCDD/DFs in the Tittabawasee River. None Zwiernik M. , Moore J. , Tazelaar D. , Kay D. P. , Hamman D. , Blankenship A., Giesy J.P. M. Zwiernik, J. Moore, D. Tazelaar, D. P. Kay, D. Hamman, A. Blankenship and J.P. Giesy. Mink and PCDD/DFs in the Tittabawasee River. To: 26th Annual Meeting, November 13-17, 2005, Baltimore MD. R831846 (2005)
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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