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Grantee Research Project Results

Publications submitted after final report Details for Grant Number R831846

Chemical Induced Changes in Gene Expression Patterns Along the HPG-axis at Different Organizational Levels Using a Small Animal Model (Japanese medaka)

RFA: Computational Toxicology and Endocrine Disruptors: Use of Systems Biology in Hazard Identification and Risk Assessment (2004)

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Abstract (2)
Journal Article (3)
Reference Type Citation Progress Report Year (Date Added to Report) Document Sources
Abstract Park J, Tompsett A, Zhang X, Newstead J, Jones P, Au D, kong R, Wu R, Giessy J, Hecker M. Fluorescence in situ hybridization techniques FISH to detect changes in CYP19a gene expression of Japanese medaka Oryzias latipes. TOXICOLOGY AND APPLIED PHARMACOLOGY 2008;232(2):226-235. R831846 (Final) (08/01/22)
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Abstract Zhang X, Hecker M, Jones P, Newstead J, Au D, Kong R, Wu R, Giessy J. Responses of the medaka HPG axis PCR array and reproduction to prochloraz and ketoconazole. ENVIRONMENTAL SCIENCE & TECHNOLOGY 2008;42(17):6762-6769 R831846 (Final) (08/01/22)
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Journal Article Park JW, Tompsett AR, Zhang X, Newsted JL, Jones PD, Au DW, Kong R, Wu RS, Giesy JP, Hecker M. Advanced fluorescence in situ hybridization to localize and quantify gene expression in Japanese medaka (Oryzias latipes) exposed to endocrine-disrupting compounds. Environmental Toxicology and Chemistry 2009;28(9):1951-1962. R831846 (Final) (03/23/12)
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Journal Article Tompsett AR, Park JW, Zhang X, Jones PD, Newsted JL, Au DWT, Chen EXH, Yu R, Wu RSS, Kong RYC, Giesy JP, Hecker M. In situ hybridization to detect spatial gene expression in medaka. Ecotoxicology and Environmental Safety 2009;72(4):1257-1264. R831846 (Final) (03/23/12)
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Journal Article Zhang X, Hecker M, Park JW, Tompsett AR, Newsted J, Nakayama K, Jones PD, Au D, Kong R, Wu RS, Giesy JP. Real-time PCR array to study effects of chemicals on the Hypothalamic-Pituitary-Gonadal axis of the Japanese medaka. Aquatic Toxicology 2008;88(3):173-182. R831846 (Final) (03/23/12)
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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Last updated April 28, 2023
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