Grantee Research Project Results
Publications Details for Grant Number R830766
Determinants of Fetal Male Rat Germ Cell Vulnerability to Phthalate Esters
RFA:
Children's Vulnerability to Toxic Substances in the Environment (2002)
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| Reference Type | Citation | Progress Report Year | Document Sources |
|---|---|---|---|
| Abstract | Howroyd P, Hoyle-Thaker R, Lyght O, Williams D, Kleymenova E. Morphology of the fetal rat testis preserved in different fixatives. The Toxicologist 2004;78(S-1):190-191. |
R830766 (2003) R830766 (Final) |
not available |
| Abstract | Kleymenova E, Dei RE, Liu K, Swanson C, Gaido K. Spermatogenesis after in utero disruption of Leydig and Sertoli cell development. Molecular Biology of the Cell 2003;14(Suppl):114a. |
R830766 (2003) |
not available |
| Abstract | Kleymenova E, Dei RE, Liu K, Swanson C, Gaido KW. Developmental exposure to di-n-butyl phthalate affects cord organization and Sertoli cell-gonocyte interactions in the fetal rat testis. The Toxicologist 2004;78(S-1):190. |
R830766 (2003) |
not available |
| Journal Article | Boekelheide K, Kleymenova E, Liu K, Swanson S, Gaido KW. Dose-dependent effects on cell proliferation, seminiferous tubules, and male germ cells in the fetal rat testis following exposure to di(n-butyl) phthalate. Microscopy Research and Technique 2009;72(8):629-638. |
R830766 (Final) |
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| Journal Article | Howroyd P, Hoyle-Thacker R, Lyght O, Williams D, Kleymenova E. Morphology of the fetal rat testis preserved in different fixatives. Toxicologic Pathology 2005;33(2):300-304. |
R830766 (2004) R830766 (2005) R830766 (Final) |
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| Journal Article | Kleymenova E, Swanson C, Boekelheide K, Gaido KW. Exposure in utero to di(n-butyl) phthalate alters the vimentin cytoskeleton of fetal rat Sertoli cells and disrupts Sertoli cell-gonocyte contact. Biology of Reproduction 2005;73(3):482-490. |
R830766 (2005) R830766 (Final) |
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| Presentation | Gaido KW. A genomics approach to investigate the effects of phthalates on male reproductive development. Presented at the Systems Biology Initiative, West Virginia University Medical Center, Morgantown, WV, November 9, 2004 (invited). |
R830766 (2004) R830766 (2005) R830766 (Final) |
not available |
| Presentation | Gaido KW. A genomics approach to investigate the effects of phthalates on male reproductive development pattern of gene expression. Presented at the Phthalate Esters & Reproductive Health Workshop 2004, Mello, France, September 23-24, 2004 (platform presentation). |
R830766 (2004) R830766 (2005) R830766 (Final) |
not available |
| Presentation | Gaido KW. Gene expression profiling reveals new targets in the etiology of phthalate-induced testicular dysgenesis. Presented at the Endocrine Disruptors Colloquium, NHEERL USEPA, Research Triangle Park, NC, April 13, 2005 (invited). |
R830766 (2004) R830766 (2005) R830766 (Final) |
not available |
| Presentation | Gaido KW. Gene expression profiling following in utero exposure to phthalate esters reveals new gene targets in the etiology of testicular dysgenesis. Presented at Brown University, Providence, RI, April 21, 2005 (invited). |
R830766 (2004) R830766 (2005) R830766 (Final) |
not available |
| Presentation | Gaido KW. Gene expression profiling reveals new targets in the etiology of phthalate-induced testicular dysgenesis. Presented at the Receptor Mechanisms Discussion Group, NIEHS, Research Triangle Park, NC, February 1, 2005 (invited). |
R830766 (2004) R830766 (2005) R830766 (Final) |
not available |
| Presentation | Gaido KW. Gene expression profiling following in utero exposure to phthalate esters reveals new targets in the etiology of testicular dysgenesis. Presented at North Carolina State University, Raleigh, NC, January 11, 2005 (invited). |
R830766 (2004) R830766 (2005) R830766 (Final) |
not available |
| Presentation | Gaido KW, Liu K. Gene expression analysis by robust singular value decomposition reveals new targets in phthalate-induced testicular dysgenesis. Presented at the Triangle Array Users Group, Research Triangle Park, NC, May 5, 2005 (invited). |
R830766 (2004) R830766 (2005) R830766 (Final) |
not available |
| Presentation | Gaido K. Gene expression profiling following in utero exposure to phthalate esters reveals new gene targets in the etiology of testicular dysgenesis. Poster presented at the XVIII North American Testis Workshop, Seattle, WA, March 30, 2005. |
R830766 (Final) |
not available |
| Presentation | Gaido K. Gene expression profiling reveals new targets in phthalate-induced testicular dysgenesis. Presented at the Eastern Carolina University, Department of Pharmacology and Toxicology, Greenville, NC, October 26, 2005. |
R830766 (Final) |
not available |
| Presentation | Howroyd P, Hoyle-Thaker R, Lyght O, Williams D, Kleymenova E. Morphology of the fetal rat testis preserved in different fixatives. Presented at the Society of Toxicology 43rd Annual Meeting, Baltimore, MD, March 21-25, 2004. |
R830766 (2003) |
not available |
| Presentation | Kleymenova E, Gaido KW. Determinants of fetal male germ cell vulnerability to phthalate esters. Poster presented at the EPA STAR Grantees Health Symposium, Philadelphia, PA, October 28, 2004. |
R830766 (2004) R830766 (2005) R830766 (Final) |
not available |
| Presentation | Kleymenova E, Boekelheide K, Swanson C, Tewksbury E, Gaido KW. Effects of di(n-butyl) phthalate on fetal development of male germ cells in the rat. Poster presented at the XVIII North American Testis Workshop, Seattle, WA, March 31, 2005. |
R830766 (2004) R830766 (2005) R830766 (Final) |
not available |
| Presentation | Kleymenova E, Swanson S, Gaido KW. Low dose cellular responses in the fetal rat testis in utero exposed to di(n-butyl) phthalate. Presented at the 44th Annual Meeting of the Society of Toxicology, New Orleans, LA, March 9, 2005 (platform presentation). |
R830766 (2004) R830766 (2005) R830766 (Final) |
not available |
| Presentation | Kleymenova E, Swanson C, Tewksbury E, Gaido KW. Development of multinucleate germ cells in the fetal testis coincides with loss of Sertoli-germ cell contact. Presented at the Society for Developmental Biology 63rd Annual Meeting, University of Calgary, Alberta, Canada, July 24-28, 2004. |
R830766 (2003) |
not available |
| Presentation | Kleymenova E, Dei RE, Liu K, Swanson C, Gaido KW. Developmental exposure to di-n-butyl phthalate affects cord organization and Sertoli cell-gonocyte interactions in the fetal rat testis. Presented at the Society of Toxicology 43rd Annual Meeting, Baltimore, MD, March 21-25, 2004. |
R830766 (2003) |
not available |
| Proceedings | Kleymenova E, Gaido KW. Determinants of fetal male germ cell vulnerability to phthalate esters. In: Proceedings of the 2004 Human Health Symposium—A STAR Progress Review Workshop, Philadelphia, PA, October 28-29, 2004. |
R830766 (2005) R830766 (Final) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.