Grantee Research Project Results
Publications Details for Grant Number R829361
Comparative In Vitro Immunotoxicology of Organochlorine Mixtures: Validation for Use in Risk Assessment
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Reference Type | Citation | Progress Report Year | Document Sources |
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Abstract | Levin M, Mori C, De Guise S. Phagocytosis is mediated by in vitro exposure to organochlorine mixtures in marine mammals and mice. In: Abstracts of the Northeast Chapter of the Society of Toxicology, Groton, CT, November 8, 2002, p. 20. |
R829361 (Final) |
not available |
Abstract | Levin M, Mori C, Morsey BM, De Guise S. Effects of in vitro exposure to organochlorine mixtures on marine mammal and mouse immune functions. In: Abstracts of the 9th Congress of the International Society of Developmental and Comparative Immunology, St. Andrews, Scotland, June 29-July 4, 2003, p. 114. |
R829361 (Final) |
not available |
Abstract | Levin M, Morsey B, Mori C, De Guise S. Modulation of innate immune functions upon in vitro exposure to organochlorine mixtures in marine mammals, humans and mice. In: Abstracts of the Annual Meeting of the North Atlantic Chapter Regional Society of Environmental Toxicology and Chemistry, Portsmouth, RI, June 9-11, 2004, p. 9. |
R829361 (Final) |
not available |
Abstract | Levin M, Morsey B, De Guise S. Modulation of phagocytosis and the respiratory burst by organochlorines in marine mammals, humans, and mice. In: Abstracts of the 10th International Congress of the International Society for Developmental and Comparative Immunology, Charleston, SC, July 1-6, 2006, p. 151. |
R829361 (Final) |
not available |
Abstract | Mori C, Morsey B, Levin M, De Guise S. Immunomodulatory effects of in vitro exposure to organochlorines in marine mammals and mice. In: Abstracts of the 15th Biennial Conference of the Biology of Marine Mammals, Greensboro, NC, December 14-19, 2003, p. 114. |
R829361 (Final) |
not available |
Abstract | Mori C, Levin M, De Guise S. Immunomodulatory effects of in vitro exposure to organochlorines on T cell proliferation in marine mammal and mice. In: Abstracts of the Northeast Chapter of the Society of Toxicology, Groton, CT, November 8, 2002, p. 21. |
R829361 (Final) |
not available |
Abstract | Mori C, Morsey B, Levin M, Nambiar PR, TrailSmith M, De Guise S. Mixture of organochlorines modulate B and T lymphocyte proliferation in marine mammals and mice and leukocyte subsets in humans and mice. In: Abstracts of the 16th Biennial Conference of the Biology of Marine Mammals, San Diego, CA, December 12-16, 2005, p. 198. |
R829361 (Final) |
not available |
Book Chapter | Brousseau P, DeGuise S, Voccia I, Ruby S, Fournier M, Vos JG, Bossart GD, Fournier M, O'Shea TJ. Immune status of St. Lawrence estuary beluga whales. Taylor & Francis, New York, NY. 2003;14:381-403. |
R829361 (2004) R829361 (Final) |
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Book Chapter | De Guise S, Beckman KB, Holladay SD, Vos JG, Bossart GD, Fournier M, O'Shea TJ. Contaminants and marine mammal immunotoxicology and pathology. Taylor & Francis, New York, NY. 2003:38-54 |
R829361 (2004) R829361 (Final) |
not available |
Book Chapter | De Guise S. Cellular immunology of cetaceans. In: Pfeiffer CJ, ed. Cell and Molecular Biology of Marine Mammals. Malabar, FL: Krieger Publishing Company, 2002, pp. 235-244. |
R829361 (2004) R829361 (Final) |
not available |
Book Chapter | Fournier M, Lalancette M, Menard L, Christin-Pich MC, DeGuise S, Brousseau P, Pelletier E, Campbell PGC, Denizeau F. Biomarquers immunologiques appliques a l'ecotoxicologie. Presses l'Universite du Quebec, Sainte-Foy, QC. 2004:401-444 |
R829361 (2004) R829361 (Final) |
not available |
Dissertation/Thesis | Levin M. Immunomodulatory effects of in vitro exposure to organochlorine mixtures in marine mammals, humans and mice. Ph.D. Dissertation. Department of Pathobiology, University of Connecticut, CT, 2004. |
R829361 (Final) |
not available |
Dissertation/Thesis | Mori C. Immunomodulatory effects of organochlorine mixtures. Ph.D. Dissertation. Department of Pathobiology, University of Connecticut, CT, 2005. |
R829361 (Final) |
not available |
Journal Article | Levin M, Morsey B, Mori C, DeGuise S. Specific non-coplanar PCB-mediated modulation of bottlenose dolphin and beluga whale phagocytosis upon in vitro exposure. Journal of Toxicology and Environmental Health-Part A-Current Issues 2004;67(19):1517-1535. |
R829361 (2004) R829361 (Final) |
not available |
Journal Article | Levin M, DeGuise S, Ross PS. Association between lymphocyte proliferation and polychlorinated biphenyls in free-ranging harbor seal (Phoca vitulina) pups from British Columbia, Canada. Environmental Toxicology and Chemistry 2005;24(5):1247-1252. |
R829361 (2004) |
not available |
Journal Article | Levin M, Morsey B, De Guise S. Calcium modulation as a possible mechanism for PCB-induced modulation of phagocytosis in marine mammals. Toxicology (submitted, 2005). |
R829361 (2004) |
not available |
Journal Article | Levin M, Morsey B, Mori C, Nambiar PR, DeGuise S. Non-coplanar PCB-mediated modulation of human leukocyte phagocytosis: A new mechanism for immunotoxicity. Journal of Toxicology and Environmental Health-Part A-Current Issues 2005;68(22):1977-1993. |
R829361 (2004) R829361 (Final) |
not available |
Journal Article | Levin M, Morsey B, Mori C, Nambiar PR, De Guise S. PCBs and TCDD, alone and in mixtures, modulate marine mammal but not B6C3F1 mouse leukocyte phagocytosis. Journal of Toxicology and Environmental Health-Part A 2005;68(8):635-656. |
R829361 (2004) R829361 (Final) |
not available |
Journal Article | Levin M, Morsey B, De Guise S. Modulation of the respiratory burst by organochlorine mixtures in marine mammals, humans and mice. Journal of Toxicology and Environmental Health-Part A 2007;70(1):73-83. |
R829361 (Final) |
not available |
Journal Article | Levin M, Morsey B, De Guise S. Non-coplanar PCBs induce calcium mobilization in bottlenose dolphin and beluga whale, but not in mouse leukocytes. Journal of Toxicology and Environmental Health Part A 2007;70(14):1220-31. |
R829361 (Final) |
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Journal Article | Mori C, Morsey B, Levin M, Nambiar PR, De Guise S. Immunomodulatory effects of in vitro exposure to organochlorines on T-cell proliferation in marine mammals and mice. Journal of Toxicology and Environmental Health-Part A 2006;69(4):283-302. |
R829361 (2004) R829361 (Final) |
not available |
Paper | Levin M, Morsey B, Mori C, Nambiar PR, De Guise S. Modulation of respiratory burst by in vitro exposure to organochlorines in marine mammals and mice (in preparation, 2005). |
R829361 (2004) |
not available |
Paper | Mori C, Morsey B, Ma X, Levin M, De Guise S. Effects of individual and mixtures of organochlorines on the mitogen-induced lymphocyte proliferation and phenotype of lymphocytes of humans and mice (in preparation, 2005). |
R829361 (2004) |
not available |
Paper | Mori C, Levin M, Morsey B, Nambiar PR, De Guise S. Immunomodulatory effects of in vitro exposure to organochlorines on B cell proliferation in marine mammals and mice (in preparation, 2005). |
R829361 (2004) |
not available |
Presentation | De Guise S, Levin M, Mori C, Morsey B, Nambiar P. Immunotoxicity of PCBs in marine mammals, mouse and humans upon in vitro exposure. Presented at the 13th International Symposium of the Pollutant Responses in Marine Organisms, Alessandria, Italy, June 19-22, 2005. |
R829361 (Final) |
not available |
Presentation | De Guise S. Comparative in vitro immunotoxicity of organochlorine mixtures. Presented at the Human Health Symposium – A Science To Achieve Results Progress Review Workshop, Washington, DC, April 9-10, 2003. |
R829361 (2004) R829361 (Final) |
not available |
Presentation | Levin M, Morsey B, Mori C, De Guise S. Non-coplanar PCB-induced modulation of phagocytosis in marine mammals, humans, and mice: new mechanisms. Presented at the Annual Meeting of the North Atlantic Chapter Regional Society of Environmental Toxicology and Chemistry, Burlington, VT, June 8-10, 2005. |
R829361 (Final) |
not available |
Presentation | Levin MJ, Mori C, De Guise S. Immunomodulatory effects of in vitro exposure to organochlorine mixtures in marine mammals and mice. Presented at the 23rd Annual Meeting of the Society for Environmental Toxicology and Chemistry, Salt Lake City, UT, November 16-20, 2002. |
R829361 (2004) |
not available |
Presentation | Levin MJ, Morsey BM, Mori C, De Guise S. Mechanisms of phagocytosis modulation upon in vitro exposure to organochlorines in marine mammals. Presented at the 24th Annual Meeting of the Society for Environmental Toxicology and Chemistry, Austin, TX, November 9-13, 2003. |
R829361 (2004) |
not available |
Presentation | Levin MJ, Morsey B, Mori C, De Guise S. Mechanisms for modulation of phagocytosis by organochlorines in bottlenose dolphins and beluga whales. Presented at the 35th Annual International Association for Aquatic Animal Medicine Conference, Galveston, TX, April 4-9, 2004. |
R829361 (2004) |
not available |
Presentation | Levin M, De Guise S. In vitro exposure to organochlorine mixtures modulates lymphocyte proliferation and phagocytosis in selected marine mammals and mice. Presented at the 14th Biennial Conference of the Biology of Marine Mammals, Vancouver, British Columbia, Canada, November 28-December 3, 2001. |
R829361 (2004) R829361 (Final) |
not available |
Presentation | Levin M, De Guise S. Effects of in vitro exposure of organochlorine mixtures on phagocytosis and lymphocyte proliferation in selected marine mammals and mice. Presented at the 32nd Annual International Association for Aquatic Animal Medicine Conference Tampa, FL, April 28-May 2, 2001. |
R829361 (2004) |
not available |
Presentation | Levin M, De Guise S, Ross PS. Contaminants and immune function in newborn harbor seals (Phoca vitulina). Presented at the 33rd Annual International Association for Aquatic Animal Medicine Conference, Albufeira, Portugal, May 4-8, 2002. |
R829361 (2004) |
not available |
Presentation | Levin M, De Guise S. Immunology and stranded marine mammals. Presented at the Northeast Regional Stranding Network Annual Meeting and Conference, Mystic, CT, May 10-12, 2002. |
R829361 (2004) R829361 (Final) |
not available |
Presentation | Levin M, Mori C, De Guise S. Phagocytosis is mediated by in vitro exposure to organochlorine mixtures in marine mammals and mice. Presented at the Northeast Chapter of the Society of Toxicology 2002 Annual Meeting, Groton, CT, November 8, 2002. |
R829361 (2004) |
not available |
Presentation | Levin M, Mori C, Morsey BM, De Guise S. Effects of in vitro exposure to organochlorine mixtures on marine mammal and mouse immune functions. Presented at the 9th Congress of the International Society of Developmental and Comparative Immunology, St. Andrews, Scotland, June 29-July 4, 2003. |
R829361 (2004) |
not available |
Presentation | Levin M, Mori C, Morsey BM, De Guise S. Immunomodulatory effects of in vitro exposure to organochlorine mixtures in marine mammals and mice. Presented at the 34th Annual International Association for Aquatic Animal Medicine Conference, Waikoloa, HI, May 9-14, 2003. |
R829361 (2004) |
not available |
Presentation | Levin M, Morsey B, Mori C, De Guise S. 2004. Modulation of innate immune functions upon in vitro exposure to organochlorine mixtures in marine mammals, humans and mice. Presented at the North Atlantic Chapter Regional Society of Environmental Toxicology and Chemistry 10th Annual Meeting, Portsmouth, RI, June 9-11, 2004. |
R829361 (2004) |
not available |
Presentation | Levin M, Morsey B, Mori C, De Guise S. Non-coplanar PCBs specifically modulate phagocytosis in dolphins, belugas, and humans but not in mice. Presented at the Northeast Chapter of the Society of Toxicology, Portland, ME, October 8, 2004. |
R829361 (2004) R829361 (Final) |
not available |
Presentation | Mori C, Levin M, De Guise S. Immunomodulatory effects of in vitro exposure to organochlorines on T cell proliferation in marine mammal and mice. Presented at the Northeast Chapter of the Society of Toxicology 2002 Annual Meeting, Groton, CT, November 8, 2002. |
R829361 (2004) |
not available |
Presentation | Mori C, Morsey B, Levin M, De Guise S. Immunomodulatory effects of in vitro exposure to organochlorines in marine mammals and mice. Presented at the 15th Biennial Conference of the Biology of Marine Mammals, Greensboro, NC, December 14-19, 2003. |
R829361 (2004) |
not available |
Presentation | Mori C, Levin M, Morsey B, De Guise S. Immunomodulatory effects of in vitro exposure to organochlorines in marine mammals and mice. Presented at the 24th Annual Meeting of the Society for Environmental Toxicology and Chemistry, Austin, TX, November 9-13, 2003. |
R829361 (2004) |
not available |
Presentation | Mori C, Levin M, Morsey B, De Guise S. Modulation of mitogen-induced lymphocyte proliferation upon in vitro exposure to organochlorines in marine mammals and mice. Presented at the North Atlantic Chapter Regional Society of Environmental Toxicology and Chemistry 10th Annual Meeting, Portsmouth, RI, June 9-11, 2004. |
R829361 (2004) |
not available |
Presentation | Mori C, Morsey B, Levin M, De Guise S. Mixtures of organochlorines modulate B and T lymphocyte proliferation in marine mammals and mice. Presented at the 25th Annual Meeting of the Society for Environmental Toxicology and Chemistry, Portland, OR, November 13-19, 2004. |
R829361 (2004) |
not available |
Presentation | Mori C, Morsey B, Levin M, Nambiar P, De Guise S. Mixtures of organochlorines modulate B and T Lymphocyte proliferation and leukocyte subsets in marine mammals, humans and mice. To be presented at the Society of Toxicology Workshop, Charting the Future: Building the Scientific Foundation for Mixtures Joint Toxicity and Risk Assessment, Atlanta, GA, February 16-17, 2005. |
R829361 (2004) R829361 (Final) |
not available |
Proceedings | De Guise S. Comparative in vitro immunotoxicity of organochlorine mixtures. In: Proceedings of the Human Health Symposium – A Science To Achieve Results Progress Review Workshop, Washington, DC: U.S. Environmental Protection Agency, December 2003, EPA/600/R-03/038, p. 27. |
R829361 (Final) |
not available |
Proceedings | Levin MJ, Mori C, De Guise S. Immunomodulatory effects of in vitro exposure to organochlorine mixtures in marine mammals and mice. In: Proceedings of the 23rd Annual Meeting of the Society for Environmental Toxicology and Chemistry, Salt Lake City, UT, November 16-20, 2002, p. 139. |
R829361 (Final) |
not available |
Proceedings | Levin MJ, Morsey BM, Mori C, De Guise S. Mechanisms of phagocytosis modulation upon in vitro exposure to organochlorines in marine mammals. In: Proceedings of the 24th Annual Meeting of the Society for Environmental Toxicology and Chemistry, Austin, TX, November 8-13, 2003, p. 20. |
R829361 (Final) |
not available |
Proceedings | Levin MJ, Morsey B, Mori C, De Guise S. Mechanisms for modulation of phagocytosis by organochlorines in bottlenose dolphins and beluga whales. In: Proceedings of the 35th Annual International Association for Aquatic Animal Medicine Conference, Galveston, TX, April 4-9, 2004, p. 141. |
R829361 (Final) |
not available |
Proceedings | Levin M, De Guise S. Effects of in vitro exposure of organochlorine mixtures on phagocytosis and lymphocyte proliferation in selected marine mammals and mice. In: Proceedings of the 32nd Annual International Association for Aquatic Animal Medicine Conference, Tampa, FL, April 28-May 2, 2001, p. 126. |
R829361 (Final) |
not available |
Proceedings | Levin M, De Guise S, Ross PS. Contaminants and immune function in newborn harbor seals (Phoca vitulina). In: Proceedings of the 33rd Annual International Association for Aquatic Animal Medicine Conference, Albufeira, Portugal, May 4-8, 2002, p. 25. |
R829361 (Final) |
not available |
Proceedings | Levin M, Mori C, Morsey BM, De Guise S. Immunomodulatory effects of in vitro exposure to organochlorine mixtures in marine mammals and mice. In: Proceedings of the 34th Annual International Association for Aquatic Animal Medicine Conference, Waikoloa HI, May 9-14, 2003, p. 69. |
R829361 (Final) |
not available |
Proceedings | Levin M, Morsey B, Mori C, Nambiar P, De Guise S. Mechanisms involved in the non-coplanar PCB –induced modulation of phagocytosis in marine mammals, humans and mice. In: Proceedings of the 36th Annual International Association for Aquatic Animal Medicine Conference, Seward, AK, May 14-18, 2005, p. 285. |
R829361 (Final) |
not available |
Proceedings | Levin M, Morsey B, Mori C, Nambiar PN, De Guise S. Mechanisms involved in the non-coplanar PCB-induced modulation of phagocytosis in marine mammals, humans, and mice. In: Proceedings of the 26th Annual meeting of the Society for Environmental Toxicology and Chemistry, Baltimore, MD, November 13-17, 2005. |
R829361 (Final) |
not available |
Proceedings | Mori C, Levin M, Morsey B, De Guise S. Immunomodulatory effects of in vitro exposure to organochlorines in marine mammals and mice. In: Proceedings of the 24th Annual Meeting of the Society for Environmental Toxicology and Chemistry, Austin, TX, November 8-13, 2003, p. 21. |
R829361 (Final) |
not available |
Proceedings | Mori C, Morsey B, Levin M, De Guise S. Mixtures of organochlorines modulate B and T lymphocyte proliferation in marine mammals and mice. In: Proceedings of the 25th Annual meeting of the Society for Environmental Toxicology and Chemistry, Portland, OR, November 14-18, 2004, p. 28. |
R829361 (Final) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.