Grantee Research Project Results
Publications Details for Grant Number R823889
Cultured Fish Cells as Model System for Studying Mechanisms of Dioxin Toxicity
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| Reference Type | Citation | Progress Report Year | Document Sources |
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| Journal Article | Bello SM, Franks DG, Stegeman JJ, Hahn ME. Acquired resistance to Ah receptor agonists in a population of Atlantic kill fish (Fundulus heteroclitus) inhabiting a marine superfund site: in vivo and in vitro studies on the inducibility of xenobiotic metabolizing enzymes. Toxicological Sciences 2001;60(1):77-91. |
R823889 (Final) |
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| Journal Article | Celander M, Hahn ME, Stegeman JJ. Cytochromes P450 (CYP) in the Poeciliopsis lucida hepatocellular carcinoma cell line (PLHC-1): dose-and time-dependent glucocorticoid potentiation of CYP1A induction without induction of CYP3A. Archives of Biochemistry and Biophysics 1996;329(1):113-122. |
R823889 (Final) |
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| Journal Article | Celander M, Bremer J, Hahn ME, Stegeman JJ. Glucocorticoid-xenobiotic interactions: dexamethasone-mediated potentiation of cytochrome P4501A induction by β-naphthoflavone in a fish hepatoma cell line (PLHC-1). Environmental Toxicology and Chemistry 1997;16(5):900-907. |
R823889 (Final) |
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| Journal Article | Cornell NW, Hahn ME, Martin HA. Characterization and use of isolated toadfish hepatocytes for studies of heme synthesis and utilization. The Biological Bulletin 1995;189(2):227-228. |
R823889 (Final) |
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| Journal Article | Hahn ME, Woodward BL, Stegeman JJ, Kennedy SW. Rapid assessment of induced cytochrome P4501A protein and catalytic activity in fish hepatoma cells grown in multi-well plates:response to TCDD, TCDF, and two planar PCBs. Environmental Toxicology and Chemistry 1996;15(4):582-591. |
R823889 (Final) |
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| Journal Article | Hahn ME, Chandran K. Uroporphyrin accumulation associated with cytochrome P4501A induction in fish hepatoma cells exposed to aryl hydrocarbon receptor agonists, including 2,3,7,8-tetrachlorodibenzo-p-dioxin and planar chlorobiphenyls. Archives of Biochemistry and Biophysics 1996;329(2):163-174. |
R823889 (Final) |
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| Journal Article | Hahn ME. Biomarkers and bioassays for detecting dioxin-like compounds in the marine environment. Science of the Total Environment 2002;289(1-3):49-69. |
R823889 (Final) |
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| Journal Article | Hestermann EV, Stegeman JJ, Hahn ME. Serum alters the uptake and relative potencies of halogenated aromatic hydrocarbons in cell culture bioassays. Toxicological Sciences 2000;53(2):316-325. |
R823889 (Final) |
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| Journal Article | Kennedy SW, Lorenzen A, Jones SP, Hahn ME, Stegeman JJ. Cytochrome P4501A induction in avian hepatocyte cultures: a promising approach for predicting the sensitivity of avian species to toxic effects of halogenated aromatic hydrocarbons. Toxicology and Applied Pharmacology 1996;141(1):214-230. |
R823889 (Final) |
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| Journal Article | Lorenzen A, Kennedy SW, Bastien LJ, Hahn ME. Halogenated aromatic hydrocarbon-mediated porphyrin accumulation and induction of cytochrome P4501A in chicken embryo hepatocytes. Biochemical Pharmacology 1997;53(3):373-384. |
R823889 (Final) |
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| Journal Article | Schlezinger JJ, Keller J, Verbrugge LA, Stegeman JJ. 3,3',4,4'-tetrachlorobiphenyl oxidation in fish, bird and reptile species: relationship to cytochrome P450 1A inactivation and reactive oxygen production. Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology 2000;125(3):273-286. |
R823889 (Final) |
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| Journal Article | White RD, Shea D, Stegeman JJ. Metabolism of the aryl hydrocarbon receptor agonist 3,3',4,4'-tetrachlorobiphenyl by the marine fish scup (Stenotomus chrysops) in vivo and in vitro. Drug Metabolism and Disposition 1997;25(5):564-572. |
R823889 (Final) R827102 (Final) |
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| Meeting | Hahn M. EPA Workshop on the Application of 2,3,7,8-TCDD Toxicity Equivalency Factors (TEFs) to Fish and Wildlife, Chicago, IL, January 1998, (invited participant). |
R823889 (Final) |
not available |
| Presentation | Hahn M. Biomarkers of dioxin sensitivity and resistance. Presented at the Biomarkers–Applications and Research, sponsored by U.S. EPA, NIEHS Superfund Program, and the Harvard School of Public Health, Boston, MA, October 1997. |
R823889 (Final) |
not available |
| Presentation | Hahn M. Biomarkers of dioxin sensitivity and resistance. Presented at the Spring Meeting of the U.S. EPA Federal and State Toxicology Risk Analysis Committee (FSTRAC), Boston, MA, May 1998. |
R823889 (Final) |
not available |
| Presentation | Hahn M. Biomarkers to detect contamination of the marine environment. Presented at Seafood Safety '98, Porto, Portugal, May 1998. |
R823889 (Final) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.