Grantee Research Project Results
Publications Details for Grant Number R825955
Development of Biomarkers for haloacetonitriles-induced cell injury in Peripheral Blood
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| Reference Type | Citation | Progress Report Year | Document Sources |
|---|---|---|---|
| Abstract | Ahmed AE, Jacob S. Dichloroacetonitrile induces oxidative stress as a mediator of apoptosis or necrosis in mouse peritoneal macrophages (MPM). The Toxicologist 1999;48(1):155. |
R825955 (Final) |
not available |
| Journal Article | Ahmed AE, Jacob S, Nouraldeen AM. Chloroacetonitrile (CAN) induces glutathione depletion and 8-hydroxylation of guanine bases in rat gastric mucosa. Journal of Biochemical and Molecular Toxicology 1999;13(3-4):119-126. |
R825955 (1999) R825955 (Final) |
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| Journal Article | Ahmed AE, Aronson J, Jacob S. Induction of oxidative stress and TNF-α secretion by dichloroacetonitrile, a water disinfectant by-product, as possible mediators of apoptosis or necrosis in a murine macrophage cell line (RAW). Toxicology in Vitro 2000;14(3):199-210. |
R825955 (2000) R825955 (Final) |
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| Journal Article | Ahmed AE, Campbell GA, Jacob S. Neurological impairment in fetal mouse brain by drinking water disinfectant byproducts. Neurotoxicology 2005;26(4):633-640. |
R825955 (Final) |
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| Journal Article | Ahmed AE, Jacob S, Campbell GA, Harirah HM, Perez-Polo JR, Johnson KM. Fetal origin of adverse pregnancy outcome: the water disinfectant by-product chloroacetonitrile induces oxidative stress and apoptosis in mouse fetal brain. Developmental Brain Research 2005;159(1):1-11. |
R825955 (Final) |
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| Journal Article | Jacob S, Abdel-Aziz AAH, Shouman SA, Ahmed AE. Effect of glutathione modulation on the distribution and transplacental uptake of 2-[14C]-chloroacetonitrile (Can) quantitative whole-body autoradiographic study in pregnant mice. Toxicology and Industrial Health 1998;14(4):533-546. |
R825955 (Final) |
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| Journal Article | Jacob S, Ahmed AE. Acrylonitrile-induced neurotoxicity in normal human astrocytes: oxidative stress and 8-hydroxy-2'-deoxyguanosine formation. Toxicology Mechanisms and Methods 2003;13(3):169-179. |
R825955 (Final) |
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| Journal Article | Jacob S, Kaphalia BS, Jacob N, Ahmed AE. The water disinfectant byproduct dibromoacetonitrile induces apoptosis in rat intestinal epithelial cells: possible role of redox imbalance. Toxicology Mechanisms and Methods 2006;16(4):227-234. |
R825955 (Final) |
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| Presentation | Ahmed AE. Biomarkers of exposure and effects in occupational health. Presented at the International Conference on Occupational Health, Cairo, Egypt, 1998. |
R825955 (Final) |
not available |
| Presentation | Ahmed AE. Biomarkers of exposure and effects in clinical toxicology. Presented at the International Conference on Environment and Primary Health Care, Cairo, Egypt, November 2000. |
R825955 (Final) |
not available |
| Presentation | Ahmed AE, Chen K-H, Ngyuen, Jacob S. Dibromoacetonitrile (DBAN), a drinking water contaminant induces oxidative damage and base excision repair in mouse fibroblasts. Presented at the Society of Toxicology, 2000. |
R825955 (Final) |
not available |
| Presentation | Ahmed AE. Development of biomarkers for Halonitrile's exposure and effects in peripheral blood. Presented at the U.S. Environmental Protection Agency 2001 Science To Achieve Results (STAR) Drinking Water Progress Review Workshop, Silver Spring, MD, February 2001. |
R825955 (Final) |
not available |
| Presentation | Ahmed AE. Biomarkers for the effect of water disinfectant byproducts: haloacetonitriles. Presented at the International Congress of Environment Toxicology and Primary Human Health, Cairo, Egypt, 2001. |
R825955 (2000) R825955 (Final) |
not available |
| Presentation | Ahmed AE, Jacob S. Chemicals induce oxidative damage that signals programmed cell death (apoptosis) machinery. Poster presented at the University of Texas Medical Branch, Environmental Pathology, Galveston, TX, 2001. |
R825955 (2000) R825955 (Final) |
not available |
| Presentation | Ahmed AE. Environmental diseases; redox imbalance and future therapies. Presented at the International Conference on Environment and Primary Health Care, Cairo, Egypt, November 2000. |
R825955 (Final) |
not available |
| Presentation | Ahmed AE. Preclinical biomarkers of toxicity. Presented at the 26th Meeting of the Egyptian Pharmaceutical Association, Cairo, Egypt, 1998. |
R825955 (Final) |
not available |
| Presentation | Jacob S, Chen K-H, Ahmed AE. Base excision repair (BER) as a molecular marker for HAN-induced DNA damage: effect of BER in mouse embryonic fibroblasts. Presented at the DNA Base Excision Repair Workshop, Sponsored by the National Institute of Environmental Health Sciences, University of Texas Medical Branch, Galveston, TX, September 2001. |
R825955 (Final) |
not available |
| Presentation | Jacob S, Chen KH, Ahmed AE. Base excision repair (BER) as a molecular marker for HAN-induced DNA damage: effect of BER in mouse embryonic fibroblasts. Presented at the DNA Base Excision Repair Workshop, University of Texas Medical Branch, Galveston, TX, 2000. Sponsored by the National Institute of Environmental Health Sciences. |
R825955 (1999) R825955 (2000) |
not available |
| Presentation | Jacob S, Ahmed AE. Interaction of p-bluescript plasmid DNA with dichloroacetonitrile. Presented to the Gulf Coast GI Research Forum, 1999. |
R825955 (1999) |
not available |
| Presentation | Mohamadin AM, El-zahaby MH, Ahmed AE. Chloroacetonitrile induced toxicity and oxidative stress in gastric epithelial cells. Presented to the Society of Toxicology, Gulf Coast Chapter, 1998. |
R825955 (1999) |
not available |
| Presentation | Tai L, Nouraldeen A, Jacob S, Ahmed AE. Role of iron in DCAN-induced plasmid (p-bluescript) DNA damage as catalyzed by Fenton-like reactions. Presented to the Society of Toxicology, Gulf Coast Chapter, 1998. |
R825955 (1999) |
not available |
| Presentation | Tran T, Chen KH, Jacob S, Ahmed AE. Dibromoacetonitrile (DBAN), a drinking water contaminant induces oxidative damage to mouse embryonic fibroblasts. Environmental poster sessions, summer programs, University of Texas Medical Branch, Galveston, TX, 1999. |
R825955 (1999) |
not available |
| Proceedings | Ahmed AE. Development of biomarkers for haloacetonitriles-induced cell injury in peripheral blood. In: Proceedings of the 2001 STAR Drinking Water Progress Review Workshop, Silver Spring, MD: U.S. Environmental Protection Agency, February 22-23, 2001, EPA/600/R-01/027. |
R825955 (Final) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.