Grantee Research Project Results
Publications Details for Grant Number R829214
Mechanisms of Air Pollutant-induced Pulmonary Inflammation; Effects of Zinc on EGFR Receptor Function
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| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
|---|---|---|---|---|---|---|
| Abstract | Zinc-induced EGF receptor requires Src-mediated phosphorylation of EGF receptor on tyrosine 845. | AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | Wu W, Graves LM, Gill GN, Samet JM | Wu W, Graves LM, Gill GN, Samet JM. Zn-induced EGF receptor requires Src-mediated phosphorylation of EGF receptor on tyrosine 845. American Journal of Respiratory and Critical Care Medicine 2002;165:A426. |
R829214 (2002) |
not available |
| Journal Article | Dependence of peroxisome proliferator-activated receptor ligand-induced mitogen-activated protein kinase signaling on epidermal growth factor receptor transactivation. | JOURNAL OF BIOLOGICAL CHEMISTRY | Gardner OS, Dewar BJ, Earp HS, Samet JM, Graves LM | Gardner OS, Dewar BJ, Earp HS, Samet JM, Graves LM. Dependence of peroxisome proliferator-activated receptor ligand-induced mitogen-activated protein kinase signaling on epidermal growth factor receptor transactivation. Journal of Biological Chemistry 2003;278(47):46261-46269. |
R829214 (Final) |
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| Journal Article | Peroxisome proliferator-activated receptor gamma-independent activation of p38 MAPK by thiazolidinediones involves calcium/calmodulin-dependent protein kinase II and protein kinase R: correlation with endoplasmic reticulum stress. | JOURNAL OF BIOLOGICAL CHEMISTRY | Gardner OS, Shiau CW, Chen CS, Graves LM | Gardner OS, Shiau CW, Chen CS, Graves LM. Peroxisome proliferator-activated receptor gamma-independent activation of p38 MAPK by thiazolidinediones involves calcium/calmodulin-dependent protein kinase II and protein kinase R: correlation with endoplasmic reticulum stress. Journal of Biological Chemistry 2005;280(11):10109-10118. |
R829214 (Final) |
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| Journal Article | Mechanisms of Zn2+-induced signal initiation through the epidermal growth factor receptor. | TOXICOLOGY AND APPLIED PHARMACOLOGY | Samet JM, Dewar BJ, Wu W, Graves LM | Samet JM, Dewar BJ, Wu W, Graves LM. Mechanisms of Zn2+-induced signal initiation through the epidermal growth factor receptor. Toxicology and Applied Pharmacology 2003;191(1):86-93. |
R829214 (2002) R829214 (Final) |
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| Journal Article | Src-dependent phosphorylation of the epidermal growth factor receptor on tyrosine 845 is required for zinc-induced Ras activation. | JOURNAL OF BIOLOGICAL CHEMISTRY | Wu W, Graves LM, Gill GN, Parsons SJ, Samet JM | Wu W, Graves LM, Gill GN, Parsons SJ, Samet JM. Src-dependent phosphorylation of the epidermal growth factor receptor on tyrosine 845 is required for zinc-induced Ras activation. Journal of Biological Chemistry 2002;277(27):24252-24257. |
R829214 (2002) R829214 (Final) |
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| Journal Article | Role of Ras in metal-induced EGF receptor signaling and NF-κB activation in human airway epithelial cells. | AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | Wu W, Jaspers I, Zhang W, Graves LM, Samet JM | Wu W, Jaspers I, Zhang W, Graves LM, Samet JM. Role of Ras in metal-induced EGF receptor signaling and NF-κB activation in human airway epithelial cells. American Journal of Physiology-Lung Cellular and Molecular Physiology 2002;282(5):L1040-L1048. |
R829214 (Final) |
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| Journal Article | Zinc-induced PTEN protein degradation through the proteasome pathway in human airway epithelial cells. | JOURNAL OF BIOLOGICAL CHEMISTRY | Wu W, Wang X, Zhang W, Reed W, Samet JM, Whang YE, Ghio AJ | Wu W, Wang X, Zhang W, Reed W, Samet JM, Whang YE, Ghio AJ. Zinc-induced PTEN protein degradation through the proteasome pathway in human airway epithelial cells. Journal of Biological Chemistry 2003;278(30):28258-28263. |
R829214 (Final) |
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| Journal Article | Heparin-binding epidermal growth factor cleavage mediates zinc-induced epidermal growth factor receptor phosphorylation. | AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | Wu W, Samet JM, Silbajoris R, Dailey LA, Sheppard D, Bromberg PA, Graves LM | Wu W, Samet JM, Silbajoris R, Dailey LA, Sheppard D, Bromberg PA, Graves LM. Heparin-binding epidermal growth factor cleavage mediates zinc-induced epidermal growth factor receptor phosphorylation. American Journal of Respiratory Cell and Molecular Biology 2004;30(4):540-547. |
R829214 (Final) |
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| Journal Article | p38 and EGF receptor kinase-mediated activation of the phosphatidylinositol 3-kinase/Akt pathway is required for Zn2+-induced cyclooxygenase-2 expression. | None | Wu W, Silbajoris RA, Whang YE, Graves LM, Bromberg PA, Samet JM | Wu W, Silbajoris RA, Whang YE, Graves LM, Bromberg PA, Samet JM. p38 and EGF receptor kinase-mediated activation of the phosphatidylinositol 3-kinase/Akt pathway is required for Zn2+-induced cyclooxygenase-2 expression. American Journal of Physiology-Lung Cellular and Molecular Physiology 2005;289(5):L883-L889. |
R829214 (Final) |
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| Presentation | Up-regulation of COX-2 expression by the EGFR/PI3K/Akt signaling pathway in human airway epithelial cells exposed to zinc ions. | None | Wu W, Silbajoris R, Zhang W, Whang YE | Wu W, Silbajoris R, Zhang W, Whang YE, et al. Up-regulation of COX-2 expression by the EGFR/PI3K/Akt signaling pathway in human airway epithelial cells exposed to zinc ions. Presented at the 2004 American Lung Association and American Thoracic Society International Conference, Orlando, FL, May 21-26, 2004. |
R829214 (Final) |
not available |
| Presentation | NFkB mediates Zn-induced COX-2 expression in human Bronchial epithelial cells. | None | Wu W, Silbajoris R, Kim Y, Jaspers I | Wu W, Silbajoris R, Kim Y, Jaspers I, et al. NFkB mediates Zn-induced COX-2 expression in human Bronchial epithelial cells. Presented at the 44th Annual Meeting of the Society of Toxicology, New Orleans, LA, March 6-10, 2005. |
R829214 (Final) |
not available |
| Presentation | Matrix metalloproteinase (MMP)-mediated phosphorylation of the epidermal growth factor receptor in human airway epithelial cells exposed to Zn. | None | Wu W, Samet JM, Silbajoris R, Dailey LA, Graves LM, Bromberg PA | Wu W, Samet JM, Silbajoris R, Dailey LA, Graves LM, Bromberg PA. Matrix metalloproteinase (MMP)-mediated phosphorylation of the epidermal growth factor receptor in human airway epithelial cells exposed to Zn. Presented at the 2003 American Lung Association/American Thoracic Society International Conference, Seattle, WA, May 16-21, 2003. |
R829214 (2002) |
not available |
| Presentation | Zn-induced EGF receptor requires Src-mediated phosphorylation of EGF receptor on tyrosine 845. | None | Wu W, Graves LM, Gill GN, Samet JM | Wu W, Graves LM, Gill GN, Samet JM. Zn-induced EGF receptor requires Src-mediated phosphorylation of EGF receptor on tyrosine 845. Presented at the 2002 American Lung Association/American Thoracic Society International Conference, Atlanta, GA, May 17-22, 2002. |
R829214 (2002) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.