Grantee Research Project Results
Journal Publications Details for Grant Number R829214
Mechanisms of Air Pollutant-induced Pulmonary Inflammation; Effects of Zinc on EGFR Receptor Function
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Reference Type | Citation | Progress Report Year | Document Sources |
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Journal Article | Gardner OS, Dewar BJ, Earp HS, Samet JM, Graves LM. Dependence of peroxisome proliferator-activated receptor ligand-induced mitogen-activated protein kinase signaling on epidermal growth factor receptor transactivation. Journal of Biological Chemistry 2003;278(47):46261-46269. |
R829214 (Final) |
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Journal Article | Gardner OS, Shiau CW, Chen CS, Graves LM. Peroxisome proliferator-activated receptor gamma-independent activation of p38 MAPK by thiazolidinediones involves calcium/calmodulin-dependent protein kinase II and protein kinase R: correlation with endoplasmic reticulum stress. Journal of Biological Chemistry 2005;280(11):10109-10118. |
R829214 (Final) |
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Journal Article | Samet JM, Dewar BJ, Wu W, Graves LM. Mechanisms of Zn2+-induced signal initiation through the epidermal growth factor receptor. Toxicology and Applied Pharmacology 2003;191(1):86-93. |
R829214 (2002) R829214 (Final) |
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Journal Article | Wu W, Graves LM, Gill GN, Parsons SJ, Samet JM. Src-dependent phosphorylation of the epidermal growth factor receptor on tyrosine 845 is required for zinc-induced Ras activation. Journal of Biological Chemistry 2002;277(27):24252-24257. |
R829214 (2002) R829214 (Final) |
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Journal Article | Wu W, Jaspers I, Zhang W, Graves LM, Samet JM. Role of Ras in metal-induced EGF receptor signaling and NF-κB activation in human airway epithelial cells. American Journal of Physiology-Lung Cellular and Molecular Physiology 2002;282(5):L1040-L1048. |
R829214 (Final) |
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Journal Article | Wu W, Wang X, Zhang W, Reed W, Samet JM, Whang YE, Ghio AJ. Zinc-induced PTEN protein degradation through the proteasome pathway in human airway epithelial cells. Journal of Biological Chemistry 2003;278(30):28258-28263. |
R829214 (Final) |
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Journal Article | Wu W, Samet JM, Silbajoris R, Dailey LA, Sheppard D, Bromberg PA, Graves LM. Heparin-binding epidermal growth factor cleavage mediates zinc-induced epidermal growth factor receptor phosphorylation. American Journal of Respiratory Cell and Molecular Biology 2004;30(4):540-547. |
R829214 (Final) |
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Journal Article | Wu W, Silbajoris RA, Whang YE, Graves LM, Bromberg PA, Samet JM. p38 and EGF receptor kinase-mediated activation of the phosphatidylinositol 3-kinase/Akt pathway is required for Zn2+-induced cyclooxygenase-2 expression. American Journal of Physiology-Lung Cellular and Molecular Physiology 2005;289(5):L883-L889. |
R829214 (Final) |
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