Grantee Research Project Results
Publications Details for Grant Number R840033
An in vitro-in silico hybrid approach for high-throughput estimation of trans-barrier permeability for chemical pollutants
RFA:
Advancing Toxicokinetics for Efficient and Robust Chemical Evaluations (2019)
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| Reference Type | Citation | Progress Report Year | Document Sources |
|---|---|---|---|
| Journal Article | Intasiri A, Illa S, Prertprawnon S, Wang S, Bell T, Li L, Li D. Comparison of in vitro membrane permeabilities of diverse environmental chemicals with in silico predictions. SCIENCE OF THE TOTAL ENVIRONMENT 2024;933 |
R840033 (2023) |
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| Journal Article | Li D, Li L. Human chemical exposure from background emissions in the United States and the implication for quantifying risks from marginal emission increase. Toxics 2021;9(11):308. |
R840033 (2022) R840033 (Final) |
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| Journal Article | Wang S, Zhang Z, Saunders L, Li D, Li L. Understanding the Impacts of Presystemic Metabolism on the Human Oral Bioavailability of Chemicals. ENVIRONMENTAL SCIENCE & TECHNOLOGY 2024; |
R840033 (2023) |
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| Journal Article | Wang S, Zhang Z, Li D. Elucidating impacts of partitioning and transmembrane permeability on absorption of chemicals in human gastrointestinal tract. Environment International 2024;193. |
R840033 (2023) R840033 (Final) |
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| Journal Article | Zhang Z, Wang S, Li L. Emerging investigator series:the role of chemical properties in human exposure to environmental chemicals. Environmental Sciences: Process Impacts 2021;23(12):1839-1862. |
R840033 (2022) R840033 (Final) |
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| Journal Article | Li D, Sangion A, Li L. Evaluating consumer exposure to disinfecting chemicals against coronavirus disease 2019 (COVID-19) and associated health risks. Environment International 2020;145:106108. |
R840033 (Final) |
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| Journal Article | Wang S, Zhang Z, Li D, Illa SE, Li L. In silico model-based exploration of the applicability of parallel artificial membrane permeability assay (PAMPA) to screen chemicals of environmental concern. Environment International 2022;170:107589. |
R840033 (Final) |
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| Journal Article | Intasiri A, Illa SE, Prertprawnon S, Wang S, Li L, Bell TW, Li D. Comparison of in vitro membrane permeabilities of diverse environmental chemicals with in silico predictions. Science of The Total Environment 2024;933:173244. |
R840033 (Final) |
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| Journal Article | Wang S, Zhang Z, Saunders LJ, Li D, Li L. Understanding the impacts of presystemic metabolism on the human oral bioavailability of chemicals. Environmental Science & Technology 2024;58(32):14135-14145. |
R840033 (Final) |
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| Presentation | Wang S, Zhang Z, Saunders L, Li D, Li L. Addressing uncertainties in oral bioavailability of chemical contaminants. Poster presented at the 33rd International Society of Exposure Society (ISES) Annual Meeting, August 27-31, 2023, Chicago, IL. |
R840033 (Final) |
not available |
| Presentation | Wang S, Zhang Z, Li D, Li L. Considerations for applying the Parallel Artificial Membrane Permeability Assay (PAMPA) in the screening of gastrointestinal absorption of chemicals of environmental or occupational concerns. Poster presented at the 62nd Society of Toxicology (SOT) Annual Meeting, March 19-23, 2023, Nashville, TN. |
R840033 (Final) |
not available |
| Presentation | Wang S, Li D, Li L. Developing an in-silico PAMPA model:considerations for applying PAMPA to chemicals of environmental concerns. Presented at the 42nd Society of Environmental Toxicology and Chemistry (SETAC) Annual Meeting, November 14-18, 2021, Portland, OR. |
R840033 (Final) |
not available |
| Presentation | Li D, Sangion A, Li L. Evaluating consumer exposure to disinfecting chemicals against coronavirus disease 2019 (COVID-19) and associated health risks. Presented at the 60th Society of Toxicology (SOT) Annual Meeting, March 12-26, 2021, [virtual]. |
R840033 (Final) |
not available |
| Presentation | Li L, Li D, Sangion A. Evaluating consumer exposure to disinfecting chemicals against coronavirus disease 2019 (COVID-19) and associated health risks. Presented at the 31st International Society of Exposure Society (ISES) Annual Meeting, August 30-September 2, 2021, [virtual]. |
R840033 (Final) |
not available |
| Presentation | Li D, Sangion A, Li L. Evaluating consumer exposure to disinfecting chemicals against coronavirus disease 2019 (COVID-19) and associated health risks. Presented the 41st Society of Environmental Toxicology and Chemistry (SETAC) North America Annual Meeting, November 15-19, 2020, [virtual]. |
R840033 (Final) |
not available |
| Presentation | Wang S, Li L, Fang M, Zhang Z, Li D. In silico model-based exploration of the relative importance of pre-and post-absorptive biotransformation in human exposure and toxicokinetic modeling. Presented at the 43rd Society of Environmental Toxicology and Chemistry (SETAC) North America Annual Meeting, November 13-17, 2022, Pittsburgh, PA. |
R840033 (Final) |
not available |
| Presentation | Wang S, Zhang Z, Li D, Li L. In-silico PAMPA model:considerations for applying PAMPA to environmental chemicals. Poster presented at the 61st Society of Toxicology (SOT) Annual Meeting, March 27-31, 2022, San Diego, CA. |
R840033 (Final) |
not available |
| Presentation | Wang S, Zhang Z, Saunders L, Li D, Li L. In-silico model-based exploration of the importance o gut metabolism in human exposure and toxicokinetic modeling. Presented at the 34th International Society of Exposure Society (ISES) Annual Meeting, October 20, 2024, Montreal, Canada. |
R840033 (Final) |
not available |
| Presentation | Wang S, Zhang Z, Saunders L, Li D, Li L. In-silico model-based exploration of the importance of gut metabolism in human exposure and toxicokinetic modeling. Poster presented at the 44th Society of Environmental Toxicology and Chemistry (SETAC) North America Annual Meeting, November 12-16, 2024, Louiville, KY. |
R840033 (Final) |
not available |
| Presentation | Wang S, Zhang Z, Li D, Li L. In-silico model-based exploration of the importance of gut metabolism in human exposure and toxicokinetic modeling. Presented at the 62nd Society of Toxicology (SOT) Annual Meeting, March 19-23, 2023, Nashville, TN. |
R840033 (Final) |
not available |
| Presentation | Wang S, Fang M, Zhang Z, Li D, Li L. In-silico model-based exploration of the importance of gut metabolism in human exposure and toxicokinetic modeling. Presented at the American Chemical Society (ACS) Fall 2023 Meeting, August 13-17, 2023, San Francisco, CA. |
R840033 (Final) |
not available |
| Presentation | Wang S, Zhang Z, Fang M, Li D, Li L. In-silico model-based exploration of the importance of gut metabolism in human exposure and toxicokinetic modeling. Poster presented at the 33rd Society of Environmental Toxicology and Chemistry (SETAC) Europe Annual Meeting, April 30-May 4, 2023, Dublin, Ireland. |
R840033 (Final) |
not available |
| Presentation | Illa S, Feng-Earley Y, Li L, Li D. Leveraging a predictive model for blood-brain-barrier permeability to enhance relevance of in vitro neurotoxicity data for in vivo risk assessment. Poster presented at the 34th International Society of Exposure Society (ISES) Annual Meeting, October 20, 2024, Montreal, Canada. |
R840033 (Final) |
not available |
| Presentation | Wang S, Zhang Z, Saunders L, Li L, Li D. Modeling the impacts of presystemic metabolism on the human oral bioavailability of chemicals. Poster presented at the 63rd Society of Toxicology Annual Meeting, March 10-14, 2024, Salt Lake City, UT. |
R840033 (Final) |
not available |
| Presentation | Li D, Li L. Population variation and non-linear dose-response relationship in assessing human health impact from background chemical emissions. Poster presented at the 61st Society of Toxicology (SOT) Annual Meeting, March 27-31, 2022, San Diego, CA. |
R840033 (Final) |
not available |
| Presentation | Wang S, Zhang Z, Li D, Illa S, Li L. Recommendations for applying PAMPA to screen gastrointestinal permeability of chemicals of environmental and occupational concern. Presented at the American Chemical Society (ACS) Fall 2023 Meeting, August 13-17, 2023, San Francisco, CA. |
R840033 (Final) |
not available |
| Presentation | Zhang Z, Wang S, Li D, Li L. The role of chemical properties in human exposure to environmental chemicals. Poster presented at the 61st Society of Toxicology (SOT) Annual Meeting, March 27-31, 2022, San Diego, CA. |
R840033 (Final) |
not available |
| Presentation | Wang S, Li L. Zhang Z, Li D. In silico model-based exploration of the applicability of Parallel Artificial Membrane Permeability Assay (PAMPA) to screen chemicals of environmental concern. Poster presented at the 43rd Society of Environmental Toxicology and Chemistry (SETAC) North America Annual Meeting, November 13-17, 2022, Pittsburgh, PA. |
R840033 (Final) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.