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Grantee Research Project Results

Journal Publications Details for Grant Number R833338

Internalization and Fate of Individual Manufactured Nanomaterial within Living Cells

RFA: Exploratory Research: Nanotechnology Research Grants Investigating Environmental and Human Health Effects of Manufactured Nanomaterials: a Joint Research Solicitation-EPA, NSF, NIOSH, NIEHS (2006)

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Journal Article (3)
Reference Type Reference Title Journal Author Citation Progress Report Year Document Sources
Journal Article Cellular recognition and trafficking of amorphous silica nanoparticles by macrophage scavenger receptor A. NANOTOXICOLOGY Orr GA, Chrisler WB, Cassens KJ, Tan R, Tarasevich BJ, Markillie LM, Zangar RC, Thrall BD Orr GA, Chrisler WB, Cassens KJ, Tan R, Tarasevich BJ, Markillie LM, Zangar RC, Thrall BD. Cellular recognition and trafficking of amorphous silica nanoparticles by macrophage scavenger receptor A. Nanotoxicology 2011;5(3):296-311. R833338 (Final)
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Journal Article Submicrometer and nanoscale inorganic particles exploit the actin machinery to be propelled along microvilli-like structures into alveolar cells. ACS NANO Orr G, Panther DJ, Phillips JL, Tarasevich BJ, Dohnalkova A, Hu D, Teeguarden JG, Pounds JG Orr G, Panther DJ, Phillips JL, Tarasevich BJ, Dohnalkova A, Hu D, Teeguarden JG, Pounds JG. Submicrometer and nanoscale inorganic particles exploit the actin machinery to be propelled along microvilli-like structures into alveolar cells. ACS Nano 2007;1(5):463-475. R833338 (2008)
R833338 (Final)
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Journal Article Syndecan-1 mediates the coupling of positively charged submicrometer amorphous silica particles with actin filaments across the alveolar epithelial cell membrane. TOXICOLOGY AND APPLIED PHARMACOLOGY Orr G, Panther DJ, Cassens KJ, Phillips JL, Tarasevich BJ, Pounds JG Orr G, Panther DJ, Cassens KJ, Phillips JL, Tarasevich BJ, Pounds JG. Syndecan-1 mediates the coupling of positively charged submicrometer amorphous silica particles with actin filaments across the alveolar epithelial cell membrane. Toxicology and Applied Pharmacology 2009;236(2):210-220. R833338 (2008)
R833338 (Final)
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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