Grantee Research Project Results
Journal Publications Details for Grant Number R828608
Development of a Physiologically Based Pharmacokinetic/ Pharmacodynamic (PBPK/PD) Model to Quantitate Biomarkers of Exposure for Organophosphate Insecticides
RFA:
Biomarkers for the Assessment of Exposure and Toxicity in Children (2000)
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| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
|---|---|---|---|---|---|---|
| Journal Article | Negative ion chemical ionization mass spectrometry for the analysis of 3,5,6-trichloro-2-pyridinol in saliva of rats exposed to chlorpyrifos. | ANALYTICAL LETTERS | Campbell JA, Timchalk C, Kousba AA, Wu H, Valenzuela BR, Hoppe EW | Campbell JA, Timchalk C, Kousba AA, Wu H, Valenzuela BR, Hoppe EW. Negative ion chemical ionization mass spectrometry for the analysis of 3,5,6-trichloro-2-pyridinol in saliva of rats exposed to chlorpyrifos. Analytical Letters 2005;38(6):939-949. |
R828608 (2003) R828608 (Final) |
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| Journal Article | Characterization of the in vitro kinetic interaction of chlorpyrifos-oxon with rat salivary cholinesterase: a potential biomonitoring matrix. | TOXICOLOGY | Kousba AA, Poet TS, Timchalk C | Kousba AA, Poet TS, Timchalk C. Characterization of the in vitro kinetic interaction of chlorpyrifos-oxon with rat salivary cholinesterase: a potential biomonitoring matrix. Toxicology 2003;188(2-3):219-232. |
R828608 (2002) R828608 (Final) |
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| Journal Article | Comparison of chlorpyrifos-oxon and paraoxon acetylcholinesterase inhibition dynamics: potential role of a peripheral binding site. | TOXICOLOGICAL SCIENCES | Kousba AA, Sultatos LG, Poet TS, Timchalk C | Kousba AA, Sultatos LG, Poet TS, Timchalk C. Comparison of chlorpyrifos-oxon and paraoxon acetylcholinesterase inhibition dynamics: potential role of a peripheral binding site. Toxicological Sciences 2004;80(2):239-248. |
R828608 (2003) R828608 (Final) |
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| Journal Article | In vitro rat hepatic and intestinal metabolism of the organophosphate pesticides chlorpyrifos and diazinon. | TOXICOLOGICAL SCIENCES | Poet TS, Wu H, Kousba AA, Timchalk C | Poet TS, Wu H, Kousba AA, Timchalk C. In vitro rat hepatic and intestinal metabolism of the organophosphate pesticides chlorpyrifos and diazinon. Toxicological Sciences 2003;72(2):193-200. |
R828608 (2002) R828608 (Final) |
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| Journal Article | Monte Carlo analysis of the human chlorpyrifos-oxonase (PON1) polymorphism using a physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model. | TOXICOLOGY LETTERS | Timchalk C, Kousba A, Poet TS | Timchalk C, Kousba A, Poet TS. Monte Carlo analysis of the human chlorpyrifos-oxonase (PON1) polymorphism using a physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model. Toxicology Letters 2002;135:(1-2):51-59. |
R828608 (2001) R828608 (Final) |
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| Journal Article | Noninvasive biomonitoring approaches to determine dosimetry and risk following acute chemical exposure: analysis of lead or organophosphate insecticide in saliva. | JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A | Timchalk C, Poet TS, Kousba AA, Campbell JA, Lin Y | Timchalk C, Poet TS, Kousba AA, Campbell JA, Lin Y. Noninvasive biomonitoring approaches to determine dosimetry and risk following acute chemical exposure: analysis of lead or organophosphate insecticide in saliva. Journal of Toxicology and Environmental Health-Part A 2004;67(8-10):635-650. |
R828608 (2003) R828608 (Final) |
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| Journal Article | Pharmacokinetic and pharmacodynamic interaction for a binary mixture of chlorpyrifos and diazinon in the rat. | TOXICOLOGY AND APPLIED PHARMACOLOGY | Timchalk C, Poet TS, Hinman MN, Busby AL, Kousba AA | Timchalk C, Poet TS, Hinman MN, Busby AL, Kousba AA. Pharmacokinetic and pharmacodynamic interaction for a binary mixture of chlorpyrifos and diazinon in the rat. Toxicology and Applied Pharmacology 2005;205(1):31-42. |
R828608 (2003) R828608 (Final) |
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