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Grantee Research Project Results

Journal Publications Details for Grant Number R831848

Systems Biology Modeling of Fathead Minnow Response to Endocrine Disruptors

RFA: Computational Toxicology and Endocrine Disruptors: Use of Systems Biology in Hazard Identification and Risk Assessment (2004)

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Journal Article (11)
Reference Type Citation Progress Report Year Document Sources
Journal Article Hemming JM, Allen HJ, Thuesen KA, Turner PK, Waller WT, Lazorchak JM, Lattier D, Chow M, Denslow N, Venables B. Temporal and spatial variability in the estrogenicity of a municipal wastewater effluent. Ecotoxicology and Environmental Safety 2004;57(3):303-310. R831848 (2006)
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Journal Article Johns S, Kane M, Denslow N, Watanabe K, Orlando E, Villeneuve D, Ankley G, Sepulveda M. Characterization of ontogenetic changes in gene expression in the fathead minnow (Pimephales promelas). ENVIRONMENTAL TOXICOLOGY 2009;28(4):873-880 R831848 (2006)
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Journal Article Knoebl I, Hemmer MJ, Denslow ND. Induction of zona radiata and vitellogenin genes in estradiol and nonylphenol exposed male sheepshead minnows (Cyprinodon variegatus). Marine Environmental Research 2004;58(2-5):547-551. R831848 (2006)
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Journal Article Knoebl I, Blum JL, Hemmer MJ, Denslow ND. Temporal gene induction patterns in sheepshead minnows exposed to 17β-estradiol. Journal of Experimental Zoology Part A: Ecological Genetics and Physiology 2006;305A(9):707-719. R831848 (2006)
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Journal Article Li Z, Villeneuve D, Jensen K, Ankley G, Watanabe K. A computational model for asynchronous oocyte growth dynamics in a batch-spawning fish. CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENCES 2006;78(1):91-102 R831848 (2006)
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Journal Article Villeneuve DL, Larkin P, Knoebl I, Miracle AL, Kahl MD, Jensen KM, Makynen EA, Durhan EJ, Carter BJ, Denslow ND, Ankley GT. A graphical systems model to facilitate hypothesis-driven ecotoxicogenomics research on the teleost brain-pituitary-gonadal axis. Environmental Science & Technology 2007;41(1):321-330. R831848 (2006)
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Journal Article Villeneuve DL, Knoebl I, Larkin P, Miracle AL, Carter BJ, Denslow ND, Ankley GT. Altered gene expression in the brain and liver of female fathead minnows Pimephales promelas Rafinesque exposed to fadrozole. Journal of Fish Biology 2008;72(9):2281-2340. R831848 (2006)
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Journal Article Villeneuve D, Garcia-Rayero N, Martinovic-Weigelt D, Li Z, Watanabe K, Orlando E, LaLone C, Edwards S, Burgoon L, Denslow N, Perkins E, Ankley G. A graphical systems model and tissue-specific functional gene sets to aid transcriptomic analysis of chemical impacts on the female teleost reproductive axis. MUTATION RESEARCH/GENETIC TOXIOCOLOGY AND ENVIRONMENTAL MUGAGENISIS 2012;746(2):151-162 R831848 (2006)
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Journal Article Watanabe KH, Jensen KM, Orlando EF, Ankley GT. What is normal? A characterization of the values and variability in reproductive endpoints of the fathead minnow, Pimephales promelas. Comparative Biochemistry and Physiology C: Toxicology & Pharmacology 2007;146(3):348-356. R831848 (2006)
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Journal Article Watanabe K, Li Z, Kroll K, Villeneuve D, Garcia-Reyero N, Orlando E, Sepulveda M, Collette T, Ekman D, Ankley G, Denslow N. A Computational Model of the Hypothalamic-Pituitary-Gonadal Axis in Male Fathead Minnows Exposed to 17α-Ethinylestradiol and 17β-Estradiol. TOXICOLOGICAL SCIENCES 2009;109(2):180-192 R831848 (2006)
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Journal Article Zhenhong L, Kroll K, Jensen K, Villeneuve D, Ankley G, Brian J, Sepulveda M, Orlando E, Lazorchak J, Kostich M, Amrstrong B, Denslow N, Watanabe K. A computational model of the hypothalamic - pituitary - gonadal axis in female fathead minnows (Pimephales promelas) exposed to 17α-ethynylestradiol and 17β-trenbolone. BMC SYSTEMS BIOLOGY 2011;5(63) R831848 (2006)
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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