Grantee Research Project Results
Journal Publications Details for Grant Number R825280
Interindividual Variations in Genetic Polymorphisms as Risks for Colorectal Cancer
RFA:
Role of Interindividual Variation in Human Susceptibility to Cancer (1996)
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| Reference Type | Citation | Progress Report Year | Document Sources |
|---|---|---|---|
| Journal Article | Coles B, Nowell SA, MacLeod SL, Sweeney C, Lang NP, Kadlubar FF. The role of human glutathione S-transferases (hGSTs) in the detoxification of the food-derived carcinogen metabolite N-acetoxy-PhIP, and the effect of a polymorphism in hGSTA1 on colorectal cancer risk. Mutation Research 2001 482(1-2):3-10. |
R825280 (Final) |
not available |
| Journal Article | Dingley KH, Curtis KD, Nowell S, Felton JS, Lang NP, Turteltaub KW. DNA and protein adduct formation in the colon and blood of humans after exposure to a dietary-relevant dose of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Cancer Epidemiology, Biomarkers & Prevention 1999;8(6):507-512. |
R825280 (Final) |
not available |
| Journal Article | Frame LT, Ozawa S, Nowell SA, Chou H-C, DeLongchamp RR, Doerge DR, Lang NP, Kadlubar FF. A simple colorimetric assay for phenotyping the major human thermostable phenol sulfotransferase (SULT1A1) using platelet cytosols. Drug Metabolism and Disposition 2000;28(9):1063-1068. |
R825280 (Final) |
not available |
| Journal Article | Lang NP, Nowell S, Malfatti MA, Kulp KS, Knize MG, Davis C, Massengill J, Williams S, MacLeod S, Dingley KH, Felton JS, Turteltaub KW. In vivo human metabolism of [2-C-14]2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine (PhIP). Cancer Letters 1999;143(2):135-138 |
R825280 (Final) |
not available |
| Journal Article | MacLeod SL, Nowell S, Massengill J, Jazieh A, McClure G, Plaxco J, Kadlubar FF, Lang NP. Cancer therapy and polymorphisms of cytochromes P450. Clinical Chemistry and Laboratory Medicine 2000;38(9):883-887. |
R825280 (Final) |
not available |
| Journal Article | Malfatti MA, Kulp KS, Knize MG, Davis C, Massengill JP, Williams S, Nowell S, MacLeod S, Dingley KH, Turteltaub KW, Lang NP, Felton JS. The identification of [2-C-14]2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine metabolites in humans. Carcinogenesis 1999;20(4):705-713 |
R825280 (Final) |
not available |
| Journal Article | Nowell SA, Massengill JS, Williams S, Radominska-Pandya A, Tephly TR, Cheng ZQ, Strassburg CP, Tukey RH, MacLeod SL, Lang NP, Kadlubar FF. Glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine by human microsomal UDP-glucuronosyltransferases: identification of specific UGT1A family isoforms involved. Carcinogenesis 1999;20(6):1107-1114 |
R825280 (Final) |
not available |
| Journal Article | Nowell S, Ambrosone CB, MacLeod SL, Williams S, Mrackova G, Plaxco J, Ozawa S, Kadlubar FF, Lang NP. Relationship of phenol sulfotransferase (SULT1A1) genotype to sulfotransferase activity phenotype in platelet cytosol. Pharmacogenetics 2000;10:789-797. |
R825280 (Final) |
not available |
| Journal Article | Ozawa S., Tang Y.M., Yamazoe Y., Kato R., Lang N.P. and Kadlubar F.F. Genetic polymorphisms in human liver phenol sulfotransferases involved in the bioactivation of N-hydroxy derivatives of carcinogenic arylamines and heterocyclic amines. Chemico-Biological Interactions, Volume 109, Issues 1-3, 20 February 1998, Pages 237-248. |
R825280 (Final) |
not available |
| Journal Article | Turteltaub KW, Dingley KH, Curtis KD, Malfatti MA, Turesky RJ, Garner RC, Felton JS, Lang NP. Macromolecular adduct formation and metabolism of heterocyclic amines in humans and rodents at low doses. Cancer Letters 1999;143(2):149-155. |
R825280 (Final) |
not available |
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