Grantee Research Project Results
Journal Publications Details for Grant Number R825955
Development of Biomarkers for haloacetonitriles-induced cell injury in Peripheral Blood
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| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
|---|---|---|---|---|---|---|
| Journal Article | Chloroacetonitrile (CAN) induces glutathione depletion and 8-hydroxylation of guanine bases in rat gastric mucosa. | JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY | Ahmed AE, Jacob S, Nouraldeen AM | Ahmed AE, Jacob S, Nouraldeen AM. Chloroacetonitrile (CAN) induces glutathione depletion and 8-hydroxylation of guanine bases in rat gastric mucosa. Journal of Biochemical and Molecular Toxicology 1999;13(3-4):119-126. |
R825955 (1999) R825955 (Final) |
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| Journal Article | Induction of oxidative stress and TNF-alpha secretion by dichloroacetonitrile, a water disinfectant by-product, as possible mediators of apoptosis or necrosis in a murine macrophage cell line (RAW). | TOXICOLOGY IN VITRO | Ahmed AE, Aronson J, Jacob S | Ahmed AE, Aronson J, Jacob S. Induction of oxidative stress and TNF-α secretion by dichloroacetonitrile, a water disinfectant by-product, as possible mediators of apoptosis or necrosis in a murine macrophage cell line (RAW). Toxicology in Vitro 2000;14(3):199-210. |
R825955 (2000) R825955 (Final) |
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| Journal Article | Neurological impairment in fetal mouse brain by drinking water disinfectant byproducts. | None | Ahmed AE, Campbell GA, Jacob S | Ahmed AE, Campbell GA, Jacob S. Neurological impairment in fetal mouse brain by drinking water disinfectant byproducts. Neurotoxicology 2005;26(4):633-640. |
R825955 (Final) |
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| Journal Article | Fetal origin of adverse pregnancy outcome: the water disinfectant by-product chloroacetonitrile induces oxidative stress and apoptosis in mouse fetal brain. | None | Ahmed AE, Jacob S, Campbell GA, Harirah HM, Perez-Polo JR, Johnson KM | Ahmed AE, Jacob S, Campbell GA, Harirah HM, Perez-Polo JR, Johnson KM. Fetal origin of adverse pregnancy outcome: the water disinfectant by-product chloroacetonitrile induces oxidative stress and apoptosis in mouse fetal brain. Developmental Brain Research 2005;159(1):1-11. |
R825955 (Final) |
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| Journal Article | Effect of glutathione modulation on the distribution and transplacental uptake of 2-[14C]- chloroacetonitrile (Can) quantitative whole-body autoradiographic study in pregnant mice. | TOXICOLOGY AND INDUSTRIAL HEALTH | Jacob S, Abdel-Aziz AAH, Shouman SA, Ahmed AE | Jacob S, Abdel-Aziz AAH, Shouman SA, Ahmed AE. Effect of glutathione modulation on the distribution and transplacental uptake of 2-[14C]-chloroacetonitrile (Can) quantitative whole-body autoradiographic study in pregnant mice. Toxicology and Industrial Health 1998;14(4):533-546. |
R825955 (Final) |
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| Journal Article | Acrylonitrile-Induced Neurotoxicity in Normal Human Astrocytes:Oxidative Stress and 8-Hydroxy-2'-Deoxyguanosine Formation. | None | Jacob S, Ahmed AE | Jacob S, Ahmed AE. Acrylonitrile-induced neurotoxicity in normal human astrocytes: oxidative stress and 8-hydroxy-2'-deoxyguanosine formation. Toxicology Mechanisms and Methods 2003;13(3):169-179. |
R825955 (Final) |
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| Journal Article | The water disinfectant byproduct dibromoacetonitrile induces apoptosis in rat intestinal epithelial cells: possible role of redox imbalance. | Toxicology Mechanisms and Methods | Jacob S, Kaphalia BS, Jacob N, Ahmed AE | Jacob S, Kaphalia BS, Jacob N, Ahmed AE. The water disinfectant byproduct dibromoacetonitrile induces apoptosis in rat intestinal epithelial cells: possible role of redox imbalance. Toxicology Mechanisms and Methods 2006;16(4):227-234. |
R825955 (Final) |
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