Grantee Research Project Results
Journal Publications Details for Grant Number R835796
System Toxicological Approaches to Define Flame Retardant Adverse Outcome Pathways
RFA:
Systems-Based Research for Evaluating Ecological Impacts of Manufactured Chemicals (2014)
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Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
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Journal Article | TBBPA chronic exposure produces sex-specific neurobehavioral and social interaction changes in adult zebrafish. | None | Chen J, Tanguay RL, Simonich M, Nie S, Zhao Y, Li L, Bai C, Dong Q, Huang C, Lin K | Chen J, Tanguay RL, Simonich M, Nie S, Zhao Y, Li L, Bai C, Dong Q, Huang C, Lin K. TBBPA chronic exposure produces sex-specific neurobehavioral and social interaction changes in adult zebrafish. Neurotoxicology and Teratology 2016;56:9-15. |
R835796 (2015) R835796 (2016) |
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Journal Article | TBBPA exposure during a sensitive developmental window produces neurobehavioral changes in larval zebrafish. | None | Chen J, Tanguay RL, Xiao Y, Haggard DE, Ge X, Jia Y, Zheng Y, Dong Q, Huang C, Lin K | Chen J, Tanguay RL, Xiao Y, Haggard DE, Ge X, Jia Y, Zheng Y, Dong Q, Huang C, Lin K. TBBPA exposure during a sensitive developmental window produces neurobehavioral changes in larval zebrafish. Environmental Pollution 2016;216:53-63. |
R835796 (2015) R835796 (2016) |
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Journal Article | Advanced morphological-behavioral test platform reveals neurodevelopmental defects in embryonic zebrafish exposed to comprehensive suite of halogenated and organophosphate flame retardants. | None | Noyes PD, Haggard DE, Gonnerman GD, Tanguay RL | Noyes PD, Haggard DE, Gonnerman GD, Tanguay RL. Advanced morphological-behavioral test platform reveals neurodevelopmental defects in embryonic zebrafish exposed to comprehensive suite of halogenated and organophosphate flame retardants.Toxicological Sciences 2015;145(1):177-195. |
R835796 (2015) R835796 (2016) |
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Journal Article | Optimizing multi-dimensional high throughput screening using zebrafish. | REPRODUCTIVE TOXICOLOGY | Truong L, Bugel SM, Chlebowski A, Usenko CY, Simonich MT, Simonich SLM, Tanguay RL | Truong L, Bugel SM, Chlebowski A, Usenko CY, Simonich MT, Simonich SLM, Tanguay RL. Optimizing multi-dimensional high throughput screening using zebrafish. Reproductive Toxicology 2016;65:139-147. |
R835168 (Final) R835796 (2017) |
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Journal Article | A new statistical approach to characterize chemical-elicited behavioral effects in high-throughput studies using zebrafish. | PLOS ONE | Zhang GZ, Truong L, Tanguay RL, Reif DM | Zhang G, Truong L, Tanguay RL, Reif DM. A new statistical approach to characterize chemical-elicited behavioral effects in high-throughput studies using zebrafish. PLoS One 2017;12(1):e0169408 (16 pp.). |
R835168 (Final) R835796 (2017) |
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Journal Article | Aggregate entropy scoring for quantifying activity across endpoints with irregular correlation structure. | REPRODUCTIVE TOXICOLOGY | Zhang G, Marvel S, Truong L, Tanguay RL, Reif DM | Zhang G, Marvel S, Truong L, Tanguay RL, Reif DM. Aggregate entropy scoring for quantifying activity across endpoints with irregular correlation structure. Reproductive Toxicology 2016;62:92-99. |
R835168 (Final) R835796 (2017) R835802 (2015) R835802 (2016) R835802 (2017) R835802 (2018) R835802C003 (2015) |
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Journal Article | A data-driven weighting scheme for multivariate phenotypic endpoints recapitulates zebrafish developmental cascades. | None | Zhang G, Roell KR, Truong L, Tanguay RL, Reif DM | Zhang G, Roell KR, Truong L, Tanguay RL, Reif DM. A data-driven weighting scheme for multivariate phenotypic endpoints recapitulates zebrafish developmental cascades. Toxicology and Applied Pharmacology 2017;314:109-117. |
R835796 (2017) R835802 (2016) R835802 (2017) R835802 (2018) |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.