Grantee Research Project Results
Journal Publications Details for Grant Number R835612
Toxicogenetics of tetrachloroethylene metabolism and toxicity: Using Collaborative Cross mouse population approach to address remaining gaps in human health assessments
RFA:
Susceptibility and Variability in Human Response to Chemical Exposure (2013)
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| Reference Type | Citation | Progress Report Year | Document Sources |
|---|---|---|---|
| Journal Article | Cichocki JA, Guyton KZ, Guha N, Chiu WA, Rusyn I, Lash LH. Target organ metabolism, toxicity, and mechanisms of trichloroethylene and perchloroethylene: key similarities, differences, and data gaps. Journal of Pharmacology and Experimental Therapeutics 2016;359(1):110-123. |
R835612 (2016) R835612 (Final) |
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| Journal Article | Cichocki JA, Furuya S, Konganti K, Luo Y-S, McDonald TJ, Iwata Y, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I. Impact of nonalcoholic fatty liver disease on toxicokinetics of tetrachloroethylene. Journal of Pharmacology and Experimental Therapeutics 2017;361(1):17-28. |
R835612 (2016) R835612 (Final) |
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| Journal Article | Cichocki JA, Furuya S, Venkatratnam A, McDonald TJ, Knap AH, Wade T, Sweet S, Chiu WA, Threadgill DW, Rusyn I. Characterization of variability in toxicokinetics and toxicodynamics of tetrachloroethylene using the Collaborative Cross mouse population. Environmental Health Perspectives 2017;125(5):057006 (12 pp.). |
R835612 (Final) |
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| Journal Article | Cichocki JA, Luo YS, Furuya S, Venkatratnam A, Konganti K, Chiu, WA, Threadgill DW, Pogribny IP. Modulation of Tetrachloroethylene-Associated Kidney Effects by Nonalcoholic Fatty Liver or Steatohepatitis in Male C57BL/6J Mice. Toxicological Sciences 2019;167(1):126-137. |
R835612 (Final) |
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| Journal Article | Dalaijamts C, Cichocki J, Luo Y, Rusyn I, Chiu W. PBPK modeling of impact of nonalcoholic fatty liver disease on toxicokinetics of perchloroethylene in mice. Toxicology and Applied Pharmacology 2020;400(115069). |
R835612 (Final) |
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| Journal Article | Ferguson KC, Luo YS, Rusyn I, Chiu WA. Comparative analysis of Rapid Equilibrium Dialysis (RED) and solid phase micro-extraction (SPME) methods for In Vitro-In Vivo extrapolation of environmental chemicals. Toxicology in Vitro2019;60:245-251 |
R835612 (Final) |
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| Journal Article | Luo Y, Ferguson K, Rusyn I, Chiu W. In Vitro Bioavailability of the Hydrocarbon Fractions of Dimethyl Sulfoxide Extracts of Petroleum Substances. Toxicological Sciences 2020;174(2):168-177. |
R835612 (Final) |
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| Journal Article | Rusyn I, Chiu W, Wright F. Model systems and organisms for addressing inter-and intra-species variability in risk assessment. REGULATORY TOXICOLOGY AND PHARMACOLOGY 2022;132(105197). |
R835612 (Final) |
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| Journal Article | Venkatratnam A, Furuya S, Kosyk O, Gold A, Bodnar W, Konganti K, Threadgill DW, Gillespie KM, Aylor DL, Wright FA, Chiu WA, Rusyn I. Collaborative Cross mouse population enables refinements to characterization of the variability in toxicokinetics of trichloroethylene and provides genetic evidence for the role of PPAR pathway in its oxidative metabolism. Toxicological Sciences 2017;158(1):48-62. |
R835612 (Final) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.