Grantee Research Project Results
2011 Progress Report: Development and Validation of the Cumulative Environmental Exposure Index for Arsenic: A Novel Environmental Public Health Indicator
EPA Grant Number: R834794Title: Development and Validation of the Cumulative Environmental Exposure Index for Arsenic: A Novel Environmental Public Health Indicator
Investigators: O'Bryant, Sid E. , Mulligan, Kevin R. , Gong, Gordon , Zhang, Yan
Institution: Texas Tech University Health Sciences Center
EPA Project Officer: Hahn, Intaek
Project Period: March 1, 2011 through February 28, 2013 (Extended to February 28, 2014)
Project Period Covered by this Report: March 1, 2011 through February 28,2012
Project Amount: $482,900
RFA: Exploring Linkages Between Health Outcomes and Environmental Hazards, Exposures, and Interventions for Public Health Tracking and Risk Management (2009) RFA Text | Recipients Lists
Research Category: Human Health
Objective:
Progress Summary:
To date, we have enrolled 206 participants into the study and we have calculated GIS-based As concentrations for each household. We also have calculated cumulative exposure at current household for each of these participants by multiplying current As concentration times the number of years living at current house (Objective 1). We have sent all water samples for these participants for assay of As levels and anticipate receiving these results within weeks.
Future Activities:
We will resume participant enrollment within 4 weeks and schedule sufficient participants to meet recruitment goals by the end of February 2013. We will soon begin building cumulative As exposure models using the data collected on the 206 participants at this point. Once we receive the groundwater As measurements, we will begin modeling direct measurement of As concentration in comparison to estimated As concentrations using existing data from the Texas Water Development Board.
Journal Articles on this Report : 4 Displayed | Download in RIS Format
Other project views: | All 23 publications | 16 publications in selected types | All 16 journal articles |
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Type | Citation | ||
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Gong G, Hargrave KA, Hobson V, Spallholz J, Boylan M, Lefforge D, O'Bryant SE. Low-level groundwater arsenic exposure impacts cognition: a Project FRONTIER study. Journal of Environmental Health 2011;74(2):16-23. |
R834794 (2011) R834794 (2012) R834794 (Final) |
Exit Exit |
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Gong G, O'Bryant SE. Low-level arsenic exposure, AS3MT gene polymorphism and cardiovascular diseases in rural Texas counties. Environmental Research 2012;113:52-57. |
R834794 (2011) R834794 (2012) R834794 (Final) |
Exit Exit Exit |
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Hall J, Edwards M, Barber R, Johnson L, Gong G, O'Bryant SE. Higher groundwater selenium exposure is associated with better memory:a Project FRONTIER study. Neuroscience & Medicine 2012;3(1):18-25. Neuroscience & Medicine |
R834794 (2011) R834794 (Final) |
Exit |
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O'Bryant SE, Edwards M, Menon CV, Gong G, Barber RC. Long-term low-level arsenic exposure is associated with poorer neuropsychological functioning: a Project FRONTIER study. International Journal of Environmental Research and Public Health 2011;8(3):861-874. |
R834794 (2011) R834794 (2012) R834794 (Final) |
Exit Exit |
Supplemental Keywords:
Water, drinking water, groundwater, exposure, risk, risk assessment, effects, health effects, human health, bioavailability, metabolism, vulnerability, sensitive populations, carcinogen, population, elderly, age, race, genetic predisposition, genetic polymorphisms, sex, ethnic groups, susceptibility, cumulative effects, toxics, heavy metals, indicators, sustainable development, public policy, decision making, community-based, psychological, social science, ecology, epidemiology, genetics, modeling, monitoring, southwest, rural, urban, EPA Region 6Progress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.