Grantee Research Project Results
2011 Progress Report: Simulated Roadway Exposure Atmospheres for Laboratory Animal and Human Studies
EPA Grant Number: R834796C002Subproject: this is subproject number 002 , established and managed by the Center Director under grant R834796
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: University of Washington Center for Clean Air Research
Center Director: Vedal, Sverre
Title: Simulated Roadway Exposure Atmospheres for Laboratory Animal and Human Studies
Investigators: McDonald, Jacob D. , Lund, Amie K.
Current Investigators: McDonald, Jacob D.
Institution: Lovelace Biomedical & Environmental Research Institute
EPA Project Officer: Callan, Richard
Project Period: December 1, 2010 through November 30, 2015 (Extended to November 30, 2017)
Project Period Covered by this Report: December 1, 2010 through July 31,2011
RFA: Clean Air Research Centers (2009) RFA Text | Recipients Lists
Research Category: Human Health , Air
Objective:
An integral component of the Center is the development of laboratory-generated atmospheres for experimental exposures of animals and humans. This Project will develop these atmospheres, with the primary objective of simulating environments containing key components of roadway emissions and the products of environmental factors that transform them. The exposures will help determine air contaminants that cause or potentiate the toxicity of roadway emissions or confound interpretations based on exposure defined by roadway proximity alone. The work that currently is under way is related to Aims 1 and 2 defined below.
Progress Summary:
Future Activities:
The dose and mixture response studies will be completed in conjunction with Project 3. In parallel, mixed atmospheres will be generated to determine the physical and chemical transformation. These atmospheres will be characterized in collaboration with Project 1, and the results will be related to field observations from Project 1.
Journal Articles:
No journal articles submitted with this report: View all 14 publications for this subprojectSupplemental Keywords:
air pollution, motor vehicle, mixtures, particulate matter, Scientific Discipline, Health, Air, ENVIRONMENTAL MANAGEMENT, Air Quality, air toxics, Health Risk Assessment, Risk Assessments, mobile sources, Environmental Monitoring, Biochemistry, Risk Assessment, ambient air quality, atmospheric particulate matter, particulate matter, aerosol particles, air pollutants, motor vehicle emissions, vehicle emissions, air quality models, motor vehicle exhaust, airway disease, bioavailability, air pollution, particle exposure, atmospheric aerosols, ambient particle health effects, vascular dysfunction, cardiotoxicity, atmospheric chemistry, exposure assessmentProgress and Final Reports:
Original AbstractMain Center Abstract and Reports:
R834796 University of Washington Center for Clean Air Research Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R834796C001 Exposure Mapping – Characterization of Gases and Particles for ExposureAssessment in Health Effects and Laboratory Studies
R834796C002 Simulated Roadway Exposure Atmospheres for Laboratory Animal and Human Studies
R834796C003 Cardiovascular Consequences of Immune Modification by Traffic-Related Emissions
R834796C004 Vascular Response to Traffic-Derived Inhalation in Humans
R834796C005 Effects of Long-Term Exposure to Traffic-Derived Particles and Gases on Subclinical Measures of Cardiovascular Disease in a Multi-Ethnic Cohort
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2016 Progress Report
- 2015 Progress Report
- 2014
- 2013 Progress Report
- 2012 Progress Report
- Original Abstract
5 journal articles for this subproject
Main Center: R834796
196 publications for this center
92 journal articles for this center