Grantee Research Project Results
Final Report: (Pilot Study): Predictors of Maternal Exposure to BPA During Pregnancy
EPA Grant Number: R834678C003Subproject: this is subproject number 003 , established and managed by the Center Director under grant R834678
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Center for Integrative Research on Childhood Leukemia and the Environment - 2015
Center Director: Metayer, Catherine
Title: (Pilot Study): Predictors of Maternal Exposure to BPA During Pregnancy
Investigators: Stotland, Naomi , Woodruff, Tracey J. , Gerona, Roy
Institution: University of California - San Francisco
EPA Project Officer: Hahn, Intaek
Project Period: May 1, 2010 through April 30, 2013
RFA: Children's Environmental Health and Disease Prevention Research Centers: Formative Centers (with NIEHS) (2009) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
To generate unprecedented data on chemical exposures during the second trimester of pregnancy, when certain aspects of fetal development are particularly vulnerable to disruption.
Summary/Accomplishments (Outputs/Outcomes):
We developed the BPA Exposure Questionnaire based on literature reviews of human exposure to bisphenol A (BPA) and measurements of BPA in various food and consumer products, and was used to evaluate dietary and non-dietary sources of exposure to BPA. The survey instrument included 197 questions regarding consumption of foods and beverages that could be contaminated with BPA due to packaging or preparation as well as occupational and non-occupational contact with paper receipts. Specifically, we asked about foods and beverages packaged in cans, cartons or paper, or served on paper plates, napkins or cups, as well as wine and beer consumption. We asked questions to capture both short-term (i.e., "today," "yesterday") as well as long-term dietary practices to assess the effects of acute and continuous BPA exposure. Finally, we also included questions about knowledge and avoidance of BPA. Seven percent of our study sample completed a self-administered questionnaire (n = 8) as part of the field testing of the questionnaire, while the remaining 93 percent completed an interview-administered survey supported by pictures and cue-cards (the BPA Exposure Questionnaire is available upon request). Previously, we identified that the length of the questionnaire was interfering with study recruitments so we reduced the number of questions based on preliminary responses to the questionnaire. Additional medical and demographic information (such as age, race/ethnicity, medications taken, smoking status etc.) were obtained from patient medical charts. We have completed all data entry and data validation for questionnaire and medical charts data in accordance with our Quality Management Plan. Among the 181 women recruited, 112 participants completed a questionnaire assessing potential sources of BPA exposure, and provided a urine sample sufficient for BPA and creatinine analysis. In addition to the questionnaire data, we have also collected 80 matched pairs of fasting and non-fasting maternal urine (from both days of the medical procedure).
Results: The questionnaire data reflect the socioeconomic status of our study population: 65 percent of participants had 12th grade or lower education, 81 percent used public health insurance, and 54 percent received food stamp assistance. We also have found that our study population consumes high quantities of fast foods and other paper-packaged take-out food, with a mean of six times/week. Total BPA concentration measured in our study population are up to three times higher compared to other studies measuring BPA in pregnant women in the U.S. and other countries worldwide.
From preliminary data, maternal urinary conjugated BPA (BPA glucuronide and BPA sulfate) levels were positively associated with educational attainment, non-African American ethnicity, household income, occupational and non-occupational exposure to paper receipts and use of food processors, and negatively associated with wine consumption. Unconjugated BPA was negatively associated with maternal body mass index (BMI). Our initial analysis indicates that receipt-related BPA exposure is a strong predictor of maternal urinary BPA and can come from both occupational and non-occupational receipt exposures. Further analysis is warranted, but if confirmed, it would provide scientific evidence for an important, yet often neglected, route of exposure. Another notable finding is that participants who have knowledge of BPA do not have lower urinary BPA levels, despite 40 percent of participants stating that they know about BPA and 27 percent of participants stating that they avoid BPA. A manuscript on results of urinary BPA levels and potential sources of BPA exposure is currently under review at Environmental Sciences and Technology. Some preliminary results also have been presented as abstracts or posters at conferences, such as the BPA Grantee Meeting, 2012, the annual Children’s Center Meeting, 2013, and the annual International Society of Environmental Epidemiology (ISEE) Conference, 2013. Fasting urinary BPA levels data and questionnaire results are currently still in the data analysis phase.
Journal Articles on this Report : 1 Displayed | Download in RIS Format
Other subproject views: | All 2 publications | 1 publications in selected types | All 1 journal articles |
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Other center views: | All 73 publications | 15 publications in selected types | All 11 journal articles |
Type | Citation | ||
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Gerona RR, Woodruff TJ, Dickenson CA, Pan J, Schwartz JM, Sen S, Friesen MW, Fujimoto VY, Hunt PA. Bisphenol-A (BPA), BPA glucuronide, and BPA sulfate in midgestation umbilical cord serum in a northern and central California population. Environmental Science & Technology 2013;47(21):12477-12485. |
R834678C001 (Final) R834678C003 (Final) |
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Supplemental Keywords:
Risk assessment, metabolism, bioavailability, ethnic groups, endocrine disruptors, sensitive populations, decision making, measurement methods;, RFA, Scientific Discipline, Health, INTERNATIONAL COOPERATION, Biochemistry, Children's Health, Environmental Policy, Biology, prenatal exposure, biological response, developmental toxicity, chemical mixtures, assessment of exposure, children's vulnerablity, children's environmental healthRelevant Websites:
UCSF Program on Reproductive Health and the Environment Exit
Progress and Final Reports:
Original AbstractMain Center Abstract and Reports:
R834678 Center for Integrative Research on Childhood Leukemia and the Environment - 2015 Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R834678C001 Assessing Maternal and Fetal Exposure to Chemicals
R834678C002 Assessing the Effects of BPA Exposure on Early Human Development
R834678C003 (Pilot Study): Predictors of Maternal Exposure to BPA During Pregnancy
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
1 journal articles for this subproject
Main Center: R834678
73 publications for this center
11 journal articles for this center