Grantee Research Project Results
2012 Progress Report: Prenatal Exposure to BPA/Phthalates: Infant Physical and Behavioral Development
EPA Grant Number: R834593C001Subproject: this is subproject number 001 , established and managed by the Center Director under grant R834593
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Water Innovation Network for Sustainable Small Systems
Center Director: Reckhow, David A.
Title: Prenatal Exposure to BPA/Phthalates: Infant Physical and Behavioral Development
Investigators: Schantz, Susan L. , Korrick, Susan A. , Baillargeon, Renee L. , Aguiar, Andrea , Flaws, Jodi , Gardiner, Joseph
Current Investigators: Schantz, Susan L.
Institution: University of Illinois Urbana-Champaign , Harvard University , Michigan State University
Current Institution: University of Illinois Urbana-Champaign
EPA Project Officer: Hahn, Intaek
Project Period: February 15, 2010 through February 14, 2014
Project Period Covered by this Report: February 15, 2012 through February 14,2013
RFA: Children's Environmental Health and Disease Prevention Research Centers: Formative Centers (with NIEHS) (2009) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
Project 1 was undertaken to develop novel methods to assess the impact of prenatal BPA or phthalate exposure on sexually dimorphic physical and behavioral endpoints during the first few months of life. An important goal is to identify reliable and valid measures of cognitive function in newborns and young infants that are sensitive to prenatal chemical exposure and predictive of lasting cognitive deficits. To complete the proposed work, a cohort of pregnant women was recruited from a local clinic. The pregnant women complete a 24-hour product use diary and provide urine samples for assessments of total BPA and 11 phthalate metabolites at 16-18 and 35-37 weeks of gestation. Key physical and cognitive outcomes are being assessed in the infants at birth, 4-5, 7-8 and 10-11 months of age. The relationship between measures of exposure and reported product use, and the relationship between maternal exposures and physical or cognitive outcomes in infants will be examined. This study will provide important pilot data about the nature of phthalate and BPA exposure in pregnant women and the risk of physical and neurodevelopmental abnormalities in their infants. The results will provide a strong basis for expansion of the pilot birth cohort into a larger prospective birth cohort with longitudinal follow-up of the children from birth through puberty.
Progress Summary:
Future Activities:
Planned activities include completion of all 7-8 and 10-11 month follow-up assessments of the infants. The 7-8 month assessments will be completed by June 30, 2013. The 10-11 month assessments will be completed by September 30, 2013. Additional goals are to complete data entry and data coding, including the abstraction of health data from medical records for the mothers during pregnancy and the infants during the first year. As data collection, entry and coding are completed, the focus will shift to data analysis and manuscript preparation.
Journal Articles:
No journal articles submitted with this report: View all 33 publications for this subprojectSupplemental Keywords:
BPA, phthalates, child development, cognition, sex differences, RFA, Health, Scientific Discipline, Environmental Chemistry, Health Risk Assessment, Risk Assessments, Biochemistry, Children's Health, biological markersRelevant Websites:
Children's Environmental Health Research Center at Illinois Exit /
Progress and Final Reports:
Original AbstractMain Center Abstract and Reports:
R834593 Water Innovation Network for Sustainable Small Systems Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R834593C001 Prenatal Exposure to BPA/Phthalates: Infant Physical and Behavioral Development
R834593C002 Adolescent Exposure to BPA/Phthalates Cognitive and Behavioral Development
R834593C003 Mechanisms of In Utero BPA Exposure on Fetal Gonad Development
R834593C004 Effects of Bisphenol A on the Developing Cortex
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
7 journal articles for this subproject
Main Center: R834593
35 publications for this center
9 journal articles for this center