Grantee Research Project Results
Final Report: Functionalized Metal Oxide Nanoparticles: Environmental Transformations and Ecotoxicity
EPA Grant Number: R833860Title: Functionalized Metal Oxide Nanoparticles: Environmental Transformations and Ecotoxicity
Investigators: Pedersen, Joel A. , Peterson, Richard E. , Hamers, Robert J. , Heideman, Warren
Institution: University of Wisconsin - Madison
EPA Project Officer: Aja, Hayley
Project Period: July 1, 2008 through June 30, 2011
Project Amount: $382,345
RFA: Exploratory Research: Nanotechnology Research Grants Investigating Fate, Transport, Transformation, and Exposure of Engineered Nanomaterials: A Joint Research Solicitation - EPA, NSF, & DOE (2007) RFA Text | Recipients Lists
Research Category: Nanotechnology , Safer Chemicals
Objective:
The main objectives of the project were to determine the extent that environmentally relevant redox processes alter metal oxide nanoparticle (NP) surface chemistry and toxicity to developing zebrafish (Danio rerio).
Summary/Accomplishments (Outputs/Outcomes):
We examined the toxicity to developing zebrafish of Fe3O4 (magnetite), CoFe2O4 (cobalt ferrite), and TiO2 NPs (anatase/rutile and anatase) in the dark and under simulated sunlight illumination. The effect of exposure to simulated oxidative environmental conditions was examined. The magnetite and cobalt ferrite NPs produced little mortality, and morphological effects were apparent only at very high (and likely environmentally unrealistic) concentrations regardless of simulated sunlight illumination. The TiO2 NPs exhibited enhanced toxicity when illuminated with simulated sunlight, which included wavelengths with energy exceeding the bandgap of the material. We investigated the photo-enhanced toxicity of TiO2 NPs using commercially available, unfunctionalized TiO2 NPs, TiO2 NPs synthesized in our labs and functionalized with organic molecules, which served as model systems for natural organic matter, and TiO2 NPs that had acquired coatings of natural organic matter.
Journal Articles on this Report : 4 Displayed | Download in RIS Format
Other project views: | All 41 publications | 6 publications in selected types | All 6 journal articles |
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Bar-Ilan O, Louis KM, Yang SP, Pedersen JA, Hamers RJ, Peterson RE, Heideman W. Titanium dioxide nanoparticles produce phototoxicity in the developing zebrafish. Nanotoxicology 2012;6(6):670-679. |
R833860 (Final) |
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Bar-Ilan O, Chuang CC, Schwahn DJ, Yang S, Joshi S, Pedersen JA, Hamers RJ, Peterson RE, Heideman W. TiO2 nanoparticle exposure and illumination during zebrafish development: mortality at parts per billion concentrations. Environmental Science & Technology 2013;47(9):4726-4733. |
R833860 (Final) |
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Bar-Ilan O, Peterson RE, Heideman W. Using zebrafish to study the biological impact of metal and metal oxide nanoparticles. International Journal of Biomedical Nanoscience and Nanotechnology 2013;3(1/2):19-37. |
R833860 (Final) |
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Yang SP, Bar-Ilan O, Peterson RE, Heideman W, Hamers RJ, Pedersen JA. Influence of humic acid on titanium dioxide nanoparticle toxicity to developing zebrafish. Environmental Science & Technology 2013;47(9):4718-4725. |
R833860 (Final) |
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Supplemental Keywords:
Water, exposure, bioavailability, metals, environmental chemistry, Health, Scientific Discipline, Risk Assessments, Biochemistry, biological pathways, CNT, bioavailability, nanotechnology, carbon fullerene, human exposure, nanomaterials, toxicologic assessment, nanoparticle toxicityProgress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.