Grantee Research Project Results
Final Report: Development of an In Vitro Test and a Prototype Model to Predict Cellular Penetration of Nanoparticles
EPA Grant Number: R833856Title: Development of an In Vitro Test and a Prototype Model to Predict Cellular Penetration of Nanoparticles
Investigators: Chen, Yongsheng , Capco, David , Chen, Zhongfang
Institution: Arizona State University , Georgia Institute of Technology , University of Puerto Rico - Rio Piedras Campus
EPA Project Officer: Hahn, Intaek
Project Period: July 1, 2008 through June 30, 2011
Project Amount: $399,628
RFA: Exploratory Research: Nanotechnology Research Grants Investigating Fate, Transport, Transformation, and Exposure of Engineered Nanomaterials: A Joint Research Solicitation - EPA, NSF, & DOE (2007) RFA Text | Recipients Lists
Research Category: Nanotechnology , Safer Chemicals
Objective:
Summary/Accomplishments (Outputs/Outcomes):
Figure 2. Comparrison of the simulated and experimental time evolution of the hydrodynamic radi of CeO2NPs(a) in KC1 solution of different ionic strength, (b) in 0.004 M CaC12 solution in the presence of 0, 1 ppm and 10 ppm humic acid (HA), and (c) in 0.01 M KC1 solutions under 4, 25 and 37ºC. The lines are model simulations
Figure 5. Aggregation kinetics of different sizes of AgNPs in HOagland medium. The data in the left column repsent the changes in hudrodynamic radii of AgNPs in open systems, while the data in the right column represent the changes in hydrodynaic radii of AgNPs in closed systems. The insets show the linerar growth of the hdrodynamic radii.
Figure 6. Attachment efficiencies of six different types of NPs, including (a) CeO2, (b) hematite, (c) ZnO, (d) C60, (e) PVP-coated AgNPs, and (f) SiNPs, as a function of ionic strength. Black circles represent experimental results obtained from the literature. [58, 64] . Red dashed lines are the simulated results for 1/W using Eq. (2). Green solid lines are the simulated results for ?m using Eq. (5)
Particles | ●OH (μM) | 1O2 (μM) | O2•− (μM) | Total (μM) | |
---|---|---|---|---|---|
TiO2 | NPs | 19.3±0.8 | 417.3±18.8 | 8.0±0.4 | 442.9±20.0 |
Bulk | 4.9±0.2 | N.D. | N.D. | 4.9±0.2 | |
CeO2 | NPs | N.D. | N.D. | 8.4±0.2 | 8.4±0.2 |
Bulk | N.D. | N.D. | N.D. | 0 | |
SiO2 | NPs | N.D. | 56.5±2.5 | N.D. | 56.5±2.5 |
Bulk | N.D. | N.D. | N.D. | 0 | |
ZnO | NPs | 9.5±0.6 | 100.8±6.4 | 167±8.6 | 277.3±15.6 |
Bulk | 1.9±0.1 | N.D. | 81.8±0.3 | 83.7±0.4 | |
CuO | NPs | N.D. | N.D. | N.D. | 0 |
Bulk | N.D. | N.D. | N.D. | 0 | |
Fe2O3 | NPs | 2.3±0.1 | N.D. | 18.1±1.1 | 20.4±1.2 |
Bulk | N.D. | N.D. | N.D. | 0 | |
Al2o3 | NPs | N.D. | N.D. | 158.5 | 158.5 |
N.D. indicates that ROS were not detected or were not statistically significant. |
Figure 8. The band edge positions of seven metal oxides in contact with aqueous
solution at pH 5.6. The lower edge of Ec (blue) and upper edge of Ev (red) are
presented along with the band gap in eV. The energy scale is drawn with respect to the
normal hydrogen electrole (NHE) and the absolute vacuum scale (AVS) as references.
On the right side of the redox potentials of several redox couples are presented.
Figure 9. Logarithmic correlation between the average concentration fo total ROS by
meal-oxide NPs (table 1) and their 2-h log(Nt/No) values. The red line indicates the
natural logarithmic function fit wiht the fitting equation shown in the graph. Error bars
not visible are small or hidden behind the data symbols.
Figure 10. Mean survival ratios (± s.d.) of P. multimicronucleatum after 48-h exposure to
NPs with varying concentrations.
Nps | 48-h C50 (mg/L) | 95% confidence intervals (mg/L) | Energy barrier (kTa) | Adsorption rate constant (m/s) |
---|---|---|---|---|
nFe2O3 | 0.81 | 0.60-1.09 | 1.36 | 3.5X10-5 |
nCuO | 0.98 | 0.84-1.25 | 1.61 | 9.26X10-6 |
nSiO2 | 442.6 | 337.0-559.8 | 10.09 | 2.75x10-10 |
nZnO | 573.8 | 448.6-707.9 | 5.71 | 5.46x10-8 |
nCeO2 | 1832.5 | 1739.9-1925.31 | 7.81 | 5.15x10-9 |
nTiO2 | 7215.2 | 3730.1-38142.7 | 31.8 | 1.45x10-19 |
nAl2O3 | 9269.2 | 4783.1-35409.6 | 33.8 | 6.62x10-21 |
akT is an energy unit. k-Boltzmann constant (1.38x10-23 JK-1); T-Absolute temperature (298K) |
Figure 11. Net interaction energy profiles between NPs and P. multimicronucleatum.
Figure 12. Relationship of the magnitude of energy barrier and the 48-h LC50
of metal oxide NPs to P. multimicronucleatum. The dashed lines represent the
linear regression (y = 271.1x-843.4, R2=0.9470).
Figure 13. AFM images of P. multimicronucleatum. (a) untreated P. multimicronucleatum; (b)
P. multimicronucleatum treated wiht nCuO of 0.5 mg/L; P. multimicronucleatum treated with
nSiO2 of 100 mg/L; (d) P. multimicronucleatumI are treated with nTiO2 of 100 mg/L. Black arrows
of NPs on the cell surfaces.
Figure 14. Exposure impacts of hermatite NPs on E. coli cells.
Figure 15. DNA binding with QDs and the shift in their conformation from linear to
spherical
References:
[1] T. Xia, N. Li, A.E. Nel, Potential health impact of nanoparticles, Annu. Rev. Publ. Health, 30 (2009) 137-150.
[2] A. Helland, M. Scheringer, M. Siegrist, H.G. Kastenholz, A. Wiek, R.W. Scholz, Risk assessment of engineered nanomaterials: A survey of industrial approaches, Environ. Sci. Technol., 42 (2008) 640-646.
[3] A.R. Petosa, D.P. Jaisi, I.R. Quevedo, M. Elimelech, N. Tufenkji, Aggregation and deposition of engineered nanomaterials in aquatic environments: role of physicochemical interactions, Environ. Sci. Technol., 44 (2010) 6532-6549.
[4] G. Aguila, F. Gracia, P. Araya, CuO and CeO2 catalysts supported on Al2O3, ZrO2, and SiO2 in the oxidation of CO at low temperature, Appl Catal A-General, 343 (2008) 16-24.
[5] K. Kaneko, K. Inoke, B. Freitag, A.B. Hungria, P.A. Midgley, T.W. Hansen, J. Zhang, S. Ohara, T. Adschiri, Structural and morphological characterization of cerium oxide nanocrystals prepared by hydrothermal synthesis, Nano Lett., 7 (2007) 421-425.
[6] S.J. Klaine, P.J.J. Alvarez, G.E. Batley, T.F. Fernandes, R.D. Handy, D.Y. Lyon, S. Mahendra, M.J. McLaughlin, J.R. Lead, Nanomaterials in the environment: Behavior, fate, bioavailability, and effects, Environ. Toxicol. Chem., 27 (2008) 1825-1851.
[7] Organization for Economic Co-operation and Development (2010) List of manufactured nanomaterials and list of endpoints for phase one of the sponsorship programme for the testing of manufactured nanomaterials: revision. Series on the Safety of Manufactured Nanomaterials No. 27. http://www.oecd.org/officialdocuments/displaydocumentpdf?cote=env/jm/mono%282010%2946&doclanguage=en. Accessed 10 August 2011.
[8] K.M. Buettner, C.I. Rinciog, S.E. Mylon, Aggregation kinetics of cerium oxide nanoparticles in monovalent and divalent electrolytes, Colloids and Surfaces a-Physicochemical and Engineering Aspects, 366 (2010) 74-79.
[9] L. Moller, H.L. Karlsson, P. Cronholm, J. Gustafsson, Copper oxide nanoparticles are highly toxic: A comparison between metal oxide nanoparticles and carbon nanotubes, Chem. Res. Toxicol., 21 (2008) 1726-1732.
[10] K.G. Li, W. Zhang, Y. Huang, Y.S. Chen, Aggregation kinetics of CeO2 nanoparticles in KCl and CaCl2 solutions: Measurements and modeling, J. Nanopart. Res., (2011) in press. DOI: 10.1007/s11051-11011-10548-z.
[11] K.L. Chen, M. Elimelech, Aggregation and deposition kinetics of fullerene (C-60) nanoparticles, langmuir, 22 (2006) 10994-11001.
[12] D.N.L. Mcgown, G.D. Parfitt, Improved theoretical calculation of stability ratio for colloidal systems, J. Phys. Chem., 71 (1967) 449-&.
[13] E.P. Honig, Roeberse.Gj, P.H. Wiersema, Effect of hydrodynamic interaction on coagulation rate of hydrophobic colloids, J. Colloid Interface Sci., 36 (1971) 97-&.
[14] Y. Zhang, Y.S. Chen, P. Westerhoff, J. Crittenden, Impact of natural organic matter and divalent cations on the stability of aqueous nanoparticles, Water Res., 43 (2009) 4249-4257.
[15] Y. Zhang, Y. Chen, P. Westerhoff, K. Hristovski, J.C. Crittenden, Stability of commercial metal oxide nanoparticles in water, Water Res., 42 (2008) 2204-2212.
[16] T.M. Benn, P. Westerhoff, Nanoparticle silver released into water from commercially available sock fabrics, Environ. Sci. Technol., 42 (2008) 4133-4139.
[17] N.R. Panyala, E.M. Pena-Mendez, J. Havel, Silver or silver nanoparticles: a hazardous threat to the environment and human health?, J. Appl. Biomed. , 6 (2008) 117-129.
[18] C.Y. Chen, C.L. Chiang, Preparation of cotton fibers with antibacterial silver nanoparticles, Mater. Lett., 62 (2008) 3607-3609.
[19] O. Choi, C.-P. Yu, G. Esteban Fernádez, Z. Hu, Interactions of nanosilver with Escherichia coli cells in planktonic and biofilm cultures, Water Research, In Press, Corrected Proof (2010).
[20] J.R. Morones, J.L. Elechiguerra, A. Camacho, K. Holt, J.B. Kouri, J.T. Ramirez, M.J. Yacaman, The bactericidal effect of silver nanoparticles, Nanotechnology, 16 (2005) 2346-2353.
[21] E. Navarro, F. Piccapietra, B. Wagner, F. Marconi, R. Kaegi, N. Odzak, L. Sigg, R. Behra, Toxicity of Silver Nanoparticles to Chlamydomonas reinhardtii, Environ. Sci. Tech., 42 (2008) 8959-8964.
[22] P.V. Asharani, Y.L. Wu, Z.Y. Gong, S. Valiyaveettil, Toxicity of silver nanoparticles in zebrafish models, Nanotechnology, 19 (2008) 8.
[23] S. Arora, J. Jain, J.M. Rajwade, K.M. Paknikar, Interactions of silver nanoparticles with primary mouse fibroblasts and liver cells, Toxicol. Appl. Pharmacol., 236 (2009) 310-318.
[24] M. Ahamed, M.A. Siddiqui, M.J. Akhtar, I. Ahmad, A.B. Pant, H.A. Alhadlaq, Genotoxic potential of copper oxide nanoparticles in human lung epithelial cells, Biochem. Biophys. Res. Commun., 396 (2010) 578-583.
[25] P.V. AshaRani, G.L.K. Mun, M.P. Hande, S. Valiyaveettil, Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells, ACS Nano, 3 (2009) 279-290.
[26] S.S. Wise, M.D. Mason, A.H. Holmes, L.C. Savery, C.T. Li, B.C. Goodale, F. Shaffiey, J.P. Wise, G. Craig, R.B. Walter, R. Payne, I.A.R. Kerr, M. Spaulding, J.P. Wise, Cytotoxicity and genotoxicity of silver nanoparticles in human and marine cell lines., Environ. Mol. Mutag., 48 (2007) 606-606.
[27] Z. Ji, X. Jin, S. George, T. Xia, H. Meng, X. Wang, E. Suarez, H. Zhang, E.M.V. Hoek, H. Godwin, A.E. Nel, J.I. Zink, Dispersion and Stability Optimization of TiO2 Nanoparticles in Cell Culture Media, Environ. Sci. Technol., 44 (2010) 7309-7314.
[28] A.A. Keller, H. Wang, D. Zhou, H.S. Lenihan, G. Cherr, B.J. Cardinale, R. Miller, Z. Ji, Stability and Aggregation of Metal Oxide Nanoparticles in Natural Aqueous Matrices, Environmental Science & Technology, 44 (2010) 1962-1967.
[29] L.T.T. Trinh, A.L. Kjoniksen, K.Z. Zhu, K.D. Knudsen, S. Volden, W.R. Glomm, B. Nystrom, Slow salt-induced aggregation of citrate-covered silver particles in aqueous solutions of cellulose derivatives, Colloid and Polymer Science, 287 (2009) 1391-1404.
[30] I.N. Throback, M. Johansson, M. Rosenquist, M. Pell, M. Hansson, S. Hallin, Silver (Ag+) reduces denitrification and induces enrichment of novel nirK genotypes in soil, FEMS Microbiol. Lett., 270 (2007) 189-194.
[31] X. Chen, H.J. Schluesener, Nanosilver: A nanoproduct in medical application, Toxicol. Lett., 176 (2008) 1-12.
[32] L. Braydich-Stolle, S. Hussain, J.J. Schlager, M.C. Hofmann, In vitro cytotoxicity of nanoparticles in mammalian germline stem cells, Toxicol. Sci., 88 (2005) 412-419.
[33] J.H. Sung, J.H. Ji, J.U. Yoon, D.S. Kim, M.Y. Song, J. Jeong, B.S. Han, J.H. Han, Y.H. Chung, J. Kim, T.S. Kim, H.K. Chang, E.J. Lee, J.H. Lee, I.J. Yu, Lung function changes in Sprague-Dawley rats after prolonged inhalation exposure to silver nanoparticles, Inhal. Toxicol., 20 (2008) 567-574.
[34] J.Y. Liu, R.H. Hurt, Ion Release Kinetics and Particle Persistence in Aqueous Nano-Silver Colloids, Environ. Sci. Tech., 44 (2010) 2169-2175.
[35] X. Jin, M. Li, J. Wang, C. Marambio-Jones, F. Peng, X. Huang, R. Damoiseaux, E.M.V. Hoek, High-Throughput Screening of Silver Nanoparticle Stability and Bacterial Inactivation in Aquatic Media: Influence of Specific Ions, Environ. Sci. Technol., 44 (2010) 7321-7328.
[36] K.M. Buettner, C.I. Rinciog, S. E.Mylon, Aggregation Kinetics of Cerium Oxide Nanoparticles in Monovalent and Divalent Electrolytes, Colloids Surf., A, 366 (2010) 74-79.
[37] K.L. Chen, S.E. Mylon, M. Elimelech, Aggregation kinetics of alginate-coated hematite nanoparticles in monovalent and divalent electrolytes, Environ. Sci. Tech., 40 (2006) 1516-1523.
[38] V.K. Sharma, Aggregation and toxicity of titanium dioxide nanoparticles in aquatic environment-A Review, Journal of Environmental Science and Health Part a-Toxic/Hazardous Substances & Environmental Engineering, 44 (2009) 1485-1495.
[39] Y.T. He, J.M. Wan, T. Tokunaga, Kinetic stability of hematite nanoparticles: the effect of particle sizes, J. Nanopart. Res., 10 (2008) 321-332.
[40] N. Kallay, S. Zalac, Stability of nanodispersions: a model for kinetics of aggregation of nanoparticles, J. Colloid Interface Sci., 253 (2002) 70-76.
[41] K. Van Hoecke, J.T.K. Quik, J. Mankiewicz-Boczek, K.A.C. De Schamphelaere, A. Elsaesser, P. Van der Meeren, C. Barnes, G. McKerr, C.V. Howard, D. Van De Meent, K. Rydzynski, K.A. Dawson, A. Salvati, A. Lesniak, I. Lynch, G. Silversmit, B. De Samber, L. Vincze, C.R. Janssen, Fate and Effects of CeO2 Nanoparticles in Aquatic Ecotoxicity Tests, Environ. Sci. Tech., 43 (2009) 4537-4546.
[42] N.B. Saleh, L.D. Pfefferle, M. Elimelech, Influence of biomacromolecules and humic acid on the aggregation kinetics of single-walled carbon nanotubes, Environ. Sci. Tech., 44 (2010) 2412-2418.
[43] Z.Q. Li, K. Greden, P.J.J. Alvarez, K.B. Gregory, G.V. Lowry, Adsorbed Polymer and NOM Limits Adhesion and Toxicity of Nano Scale Zerovalent Iron to E. coli, Environ. Sci. Tech., 44 (2010) 3462-3467.
[44] A.R. Petosa, D.P. Jaisi, I.R. Quevedo, M. Elimelech, N. Tufenkji, Aggregation and deposition of engineered nanomaterials in aquatic environments: role of physicochemical interactions, Environ. Sci. Technol., 44 (2010) 6532-6549.
[45] K.L. Chen, M. Elimelech, Relating colloidal stability of fullerene (C-60) nanoparticles to nanoparticle charge and electrokinetic properties, Environ. Sci. Technol., 43 (2009) 7270-7276.
[46] R.A. French, A.R. Jacobson, B. Kim, S.L. Isley, R.L. Penn, P.C. Baveye, Influence of ionic strength, pH, and cation valence on aggregation kinetics of Titanium dioxide nanoparticles, Environ. Sci. Technol., 43 (2009) 1354-1359.
[47] J. Gao, S. Youn, A. Hovsepyan, V.L. Llaneza, Y. Wang, G. Bitton, J.C.J. Bonzongo, Dispersion and toxicity of selected manufactured nanomaterials in natural river water samples: effects of water chemical composition, Environ. Sci. Technol., 43 (2009) 3322-3328.
[48] V.K. Sharma, Aggregation and toxicity of titanium dioxide nanoparticles in aquatic environment-A Review, J. Environ. Sci. Health, Part A: Environ. Sci. Eng. , 44 (2009) 1485-1495.
[49] A.M. El Badawy, T.P. Luxton, R.G. Silva, K.G. Scheckel, M.T. Suidan, T.M. Tolaymat, Impact of environmental conditions (pH, ionic strength, and electrolyte type) on the surface charge and aggregation of silver nanoparticles suspensions, Environ. Sci. Technol., 44 (2010) 1260-1266.
[50] K. Li, W. Zhang, Y. Huang, Y. Chen, Aggregation kinetics of CeO2 nanoparticles in KCl and CaCl2 solutions: Measurements and modeling, J. Nanopart. Res., DOI: 10.1007/s11051-011-0548-z (2011).
[51] P. Yi, K.L. Chen, Influence of surface oxidation on the aggregation and deposition kinetics of multiwalled carbon nanotubes in monovalent and divalent electrolytes, langmuir, 27 (2011) 3588-3599.
[52] S.H. Behrens, D.I. Christl, R. Emmerzael, P. Schurtenberger, M. Borkovec, Charging and aggregation properties of carboxyl latex particles:experiments versus DLVO theory, langmuir, 16 (2000) 2566-2575.
[53] N.B. Saleh, L.D. Pfefferle, M. Elimelech, Aggregation kinetics of multiwalled carbon nanotubes in aquatic systems: measurements and environmental implications, Environ. Sci. Technol., 42 (2008) 7963-7969.
[54] C. Shen, B. Li, Y. Huang, Y. Jin, Kinetics of coupled primary- and secondary-minimum deposition of colloids under unfavorable chemical conditions, Environ. Sci. Tech., 41 (2007) 6976-6982.
[55] M.W. Hahn, D. Abadzic, C.R. O'Melia, Aquasols:on the role of secondary minima, Environ. Sci. Tech., 38 (2004) 5915-5924.
[56] N. Tufenkji, M. Elimelech, Breakdown of colloid filtration theory:role of the secondary energy minimum and surface charge heterogeneities, Langmuir, 21 (2005) 841-852.
[57] R.L. Penn, Kinetics of oriented aggregation, J. Phys. Chem. B, 108 (2004) 12707-12712.
[58] V.Y. Rudyak, S.L. Krasnolutskii, D.A. Ivanov, Molecular dynamics simulation of nanoparticle diffusion in dense fluids, Microfluidics and Nanofluidics, 11 (2011) 501-506.
[59] K.J. Laidler, Chemical Kinetics, Third Edition ed., Prentice Hall, 1997.
[60] P.L. Houston, Chemical Kinetics and Reaction Dynamics, Second Edition ed., Dover Publications 2006.
[61] A. Pierres, A.-M. Benoliel, C. Zhu, P. Bongrand, Diffusion of microspheres in shear flow near a wall: use to measure binding rates between attached molecules, Biophys. J., 81 (2001) 25-42.
[62] K. Kendall, A. Dhir, S.F. Du, A new measure of molecular attractions between nanoparticles near kT adhesion energy, Nanotechnology, 20 (2009).
[63] K.A. Huynh, K.L. Chen, Aggregation kinetics of citrate and polyvinylpyrrolidone coated silver nanoparticles in monovalent and divalent electrolyte solutions, Environ. Sci. Tech., 45 (2011) 5564-5571.
[64] J. Crittenden, Water Treatment: Principles and Design Wiley; 2 edition, 2005.
[65] T. Xia, M. Kovochich, J. Brant, M. Hotze, J. Sempf, T. Oberley, C. Sioutas, J.I. Yeh, M.R. Wiesner, A.E. Nel, Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm, Nano letters, 6 (2006) 1794-1807.
[66] T. Xia, M. Kovochich, M. Liong, L. Ma dler, B. Gilbert, H. Shi, J.I. Yeh, J.I. Zink, A.E. Nel, Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties, Acs Nano, 2 (2008) 2121-2134.
[67] E. Burello, A.P. Worth, A theoretical framework for predicting the oxidative stress potential of oxide nanoparticles, Nanotoxicology, 5 (2011) 228-235.
[68] L.K. Adams, D.Y. Lyon, P.J. Alvarez, Comparative eco-toxicity of nanoscale TiO2, SiO2, and ZnO water suspensions, Water research, 40 (2006) 3527-3532.
[69] Y.W. Baek, Y.J. An, Microbial toxicity of metal oxide nanoparticles (CuO, NiO, ZnO, and Sb2O3) to Escherichia coli, Bacillus subtilis, and Streptococcus aureus, Science of the Total Environment, 409 (2011) 1603-1608.
[70] O. Zeyons, A. Thill, F. Chauvat, N. Menguy, C. Cassier-Chauvat, C. Oréar, J. Daraspe, M. Auffan, J. Rose, O. Spalla, Direct and indirect CeO2 nanoparticles toxicity for Escherichia coli and Synechocystis, Nanotoxicology, 3 (2009) 284-295.
[71] J.M. Veranth, E.G. Kaser, M.M. Veranth, M. Koch, G.S. Yost, Cytokine responses of human lung cells (BEAS-2B) treated with micron-sized and nanoparticles of metal oxides compared to soil dusts, Part Fibre Toxicol, 4 (2007).
[72] H.L. Karlsson, P. Cronholm, J. Gustafsson, L. Möller, Copper oxide nanoparticles are highly toxic: A comparison between metal oxide nanoparticles and carbon nanotubes, Chemical research in toxicology, 21 (2008) 1726-1732.
[73] W. Jiang, H. Mashayekhi, B. Xing, Bacterial toxicity comparison between nano- and micro-scaled oxide particles, Environmental Pollution, 157 (2009) 1619-1625.
[74] A. Nel, T. Xia, L. M dler, N. Li, Toxic potential of materials at the nanolevel, Science, 311 (2006) 622. [75] O. Choi, Z. Hu, Size dependent and reactive oxygen species related nanosilver toxicity to nitrifying bacteria, Environmental science & technology, 42 (2008) 4583-4588.
[76] T. Soeborg, F. Ingerslev, B. Hallingsorensen, Chemical stability of chlortetracycline and chlortetracycline degradation products and epimers in soil interstitial water, Chemosphere, 57 (2004) 1515-1524.
[77] M. Auffan, J. Rose, M.R. Wiesner, J.-Y. Bottero, Chemical stability of metallic nanoparticles: A parameter controlling their potential cellular toxicity in vitro, Environmental Pollution, 157 (2009) 1127-1133.
[78] M. Grätzel, Photoelectrochemical cells, Nature, 414 (2001) 338–344.
[79] C.D. Vecitis, K.R. Zodrow, S. Kang, M. Elimelech, Electronic-Structure-Dependent Bacterial Cytotoxicity of Single-Walled Carbon Nanotubes, ACS Nano, 4 (2010) 5471-5479.
[80] L. Brunet, D.Y. Lyon, E.M. Hotze, P.J.J. Alvarez, M.R. Wiesner, Comparative photoactivity and antibacterial properties of C60 fullerenes and titanium dioxide nanoparticles, Environmental science & technology, 43 (2009) 4355-4360.
[81] W. Zhang, M. Kalive, D.G. Capco, Y. Chen, Adsorption of hematite nanoparticles onto Caco-2 cells and the cellular impairments: effect of particle size, Nanotechnology, 21 (2010) 355103.
[82] W. Zhang, Y. Yao, N. Sullivan, Y. Chen, Modeling the Primary Size Effects of Citrate-Coated Silver Nanoparticles on Their Ion Release Kinetics, Environmental science & technology, 45 (2011) 4422-4428.
[83] A. Thill, O. Zeyons, O. Spalla, F. Chauvat, J. Rose, M. Auffan, A.M. Flank, Cytotoxicity of CeO2 nanoparticles for Escherichia coli. Physico-chemical insight of the cytotoxicity mechanism, Environmental science & technology, 40 (2006) 6151-6156.
[84] A.M. Schrand, M.F. Rahman, S.M. Hussain, J.J. Schlager, D.A. Smith, A.F. Syed, Metal-based nanoparticles and their toxicity assessment, Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2 (2010) 544-568.
[85] X.S. Zhu, Y. Chang, Y.S. Chen, Toxicity and bioaccumulation of TiO(2) nanoparticle aggregates in Daphnia magna, Chemosphere, 78 (2010) V-215.
[86] E. Navarro, A. Baun, R. Behra, N.B. Hartmann, J. Filser, A.J. Miao, A. Quigg, P.H. Santschi, L. Sigg, Environmental behavior and ecotoxicity of engineered nanoparticles to algae, plants, and fungi, Ecotoxicology, 17 (2008) 372-386.
[87] X.S. Zhu, L. Zhu, Y.S. Chen, S.Y. Tian, Acute toxicities of six manufactured nanomaterial suspensions to Daphnia magna, J. Nanopart. Res., 11 (2009) 67-75.
[88] Y. Chang, X.S. Zhu, J.X. Wang, X.Z. Zhang, Y.S. Chen, Trophic transfer of TiO2 nanoparticles from daphnia to zebrafish in a simplified freshwater food chain, Chemosphere, 79 (2010) 928-933.
[89] K. Feris, C. Otto, J. Tinker, D. Wingett, A. Punnoose, A. Thurber, M. Kongara, M. Sabetian, B. Quinn, C. Hanna, D. Pink, Electrostatic Interactions Affect Nanoparticle-Mediated Toxicity to Gram-Negative Bacterium Pseudomonas aeruginosa PAO1, Langmuir, 26 (2010) 4429-4436.
[90] C. Pagnout, S. Jomini, M. Dadhwal, C. Caillet, F. Thomas, P. Bauda, Role of electrostatic interactions in the toxicity of titanium dioxide nanoparticles toward Escherichia coli, Colloids and Surfaces B: Biointerfaces, 92 (2012) 315-321.
[91] Y. Wang, W. Aker, H.M. Hwang, C. Yedjou, H. Yu, P.B. Tchounwou, A study of the mechanism of in vitro cytotoxicity of metal oxide nanoparticles using catfish primary hepatocytes and human HepG2 cells, Sci. Total Environ., 409 (2011) 4753-4762.
[92] X.K. Hu, S. Cook, P. Wang, H.M. Hwang, In vitro evaluation of cytotoxicity of engineered metal oxide nanoparticles, Sci. Total Environ., 407 (2009) 3070-3072.
[93] A. Thill, O. Zeyons, O. Spalla, F. Chauvat, J. Rose, M. Auffan, A.M. Flank, Cytotoxicity of CeO2 nanoparticles for Escherichia coli. Physico-chemical insight of the cytotoxicity mechanism, Environ. Sci. Technol., 40 (2006) 6151-6156.
[94] T. Xia, M. Kovochich, M. Liong, L. Madler, B. Gilbert, H.B. Shi, J.I. Yeh, J.I. Zink, A.E. Nel, Comparison of the Mechanism of Toxicity of Zinc Oxide and Cerium Oxide Nanoparticles Based on Dissolution and Oxidative Stress Properties, ACS Nano, 2 (2008) 2121-2134.
[95] W. Jiang, H. Mashayekhi, B.S. Xing, Bacterial toxicity comparison between nano- and micro-scaled oxide particles, Environ. Pollut., 157 (2009) 1619-1625.
[96] P.K. Stoimenov, R.L. Klinger, G.L. Marchin, K.J. Klabunde, Metal oxide nanoparticles as bactericidal agents, Langmuir, 18 (2002) 6679-6686.
[97] A.M. El Badawy, R.G. Silva, B. Morris, K.G. Scheckel, M.T. Suidan, T.M. Tolaymat, Surface Charge-Dependent Toxicity of Silver Nanoparticles, Environ. Sci. Technol., 45 (2011) 283-287.
[98] C.M. Goodman, C.D. McCusker, T. Yilmaz, V.M. Rotello, Toxicity of gold nanoparticles functionalized with cationic and anionic side chains, Bioconjugate Chem., 15 (2004) 897-900.
[99] I. Sondi, B. Salopek-Sondi, Silver nanoparticles as antimicrobial agent: a case study on E-coli as a model forGram-negative bacteria, J. Colloid Interface Sci., 275 (2004) 177-182.
[100] B.D. Chithrani, W.C.W. Chan, Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes, Nano Lett., 7 (2007) 1542-1550.
[101] A.E. Nel, L. Madler, D. Velegol, T. Xia, E.M.V. Hoek, P. Somasundaran, F. Klaessig, V. Castranova, M. Thompson, Understanding biophysicochemical interactions at the nano-bio interface, Nat. Mater., 8 (2009) 543-557.
[102] J.Q. Lin, H.W. Zhang, Z. Chen, Y.G. Zheng, Penetration of Lipid Membranes by Gold Nanoparticles: Insights into Cellular Uptake, Cytotoxicity, and Their Relationship, ACS Nano, 4 (2010) 5421-5429.
[103] A. Verma, O. Uzun, Y.H. Hu, Y. Hu, H.S. Han, N. Watson, S.L. Chen, D.J. Irvine, F. Stellacci, Surface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles, Nat. Mater., 7 (2008) 588-595.
[104] T. Xia, M. Kovochich, M. Liong, J.I. Zink, A.E. Nel, Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways, ACS Nano, 2 (2008) 85-96.
[105] T. Cedervall, I. Lynch, S. Lindman, T. Berggard, E. Thulin, H. Nilsson, K.A. Dawson, S. Linse, Understanding the nanoparticle-protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles, Proc. Natl. Acad. Sci. U. S. A., 104 (2007) 2050-2055.
[106] M. Green, E. Howman, Semiconductor quantum dots and free radical induced DNA nicking, Chem. Commun. (Cambridge, U. K.), (2005) 121-123.
[107] G. Bhabra, A. Sood, B. Fisher, L. Cartwright, M. Saunders, W.H. Evans, A. Surprenant, G. Lopez-Castejon, S. Mann, S.A. Davis, L.A. Hails, E. Ingham, P. Verkade, J. Lane, K. Heesom, R. Newson, C.P. Case, Nanoparticles can cause DNA damage across a cellular barrier, Nat. Nanotechnol., 4 (2009) 876-883.
[108] K.G. Li, Y.S. Chen, Effect of natural organic matter on the aggregation kinetics of CeO2 nanoparticles in KCl and CaCl2 solutions: measurements and modeling, J. Hazard. Mater., (2012) in press. DOI: 10.1016/j.jhazmat.2012.1001.1013.
[109] R.C. Murdock, L. Braydich-Stolle, A.M. Schrand, J.J. Schlager, S.M. Hussain, Characterization of nanomaterial dispersion in solution prior to In vitro exposure using dynamic light scattering technique, Toxicol. Sci., 101 (2008) 239-253.
[110] W. Zhang, M. Kalive, D.G. Capco, Y. Chen, Adsorption of hematite nanoparticles onto Caco-2 cells and the cellular impairments: effect of particle size Nanotechnology, 21 (2010) 355103.
[111] W. Zhang, Y. Yao, Y. Chen, Imaging and Quantifying the Morphology and Nanoelectrical Properties of Quantum Dot Nanoparticles Interacting with DNA, J. Phys. Chem. C, (2010) DOI:10.1021/jp107676h.
[112] S.J. Lin, G. Keskar, Y.N. Wu, X. Wang, A.S. Mount, S.J. Klaine, J.M. Moore, A.M. Rao, P.C. Ke, Detection of phospholipid-carbon nanotube translocation using fluorescence energy transfer, Appl. Phys. Lett., 89 (2006) 143118-143121.
[113] J.K. Lee, Toxicity and tissue distribution of magnetic nanoparticles in mice, Toxicol. Sci., 90 (2006) 267-267.
[114] M. Geiser, B. Rothen-Rutishauser, N. Kapp, S. Schurch, W. Kreyling, H. Schulz, M. Semmler, V.I. Hof, J. Heyder, P. Gehr, Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells, Environ. Health Perspect., 113 (2005) 1555-1560.
Journal Articles on this Report : 66 Displayed | Download in RIS Format
Other project views: | All 88 publications | 66 publications in selected types | All 66 journal articles |
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Chen W, Li Y, Yu G, Zhou Z, Chen Z. Electronic structure and reactivity of boron nitride nanoribbons with Stone-Wales defects. Journal of Chemical Theory and Computation 2009;5(11):3088-3095. |
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Chen W, Li Y, Yu G, Li C-Z, Zhang SB, Zhou Z, Chen Z. Hydrogenation: a simple approach to realize semiconductor-half-metal-metal transition in boron nitride nanoribbons. Journal of the American Chemical Society 2010;132(5):1699-1705. |
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Chivers T, Hilts RW, Jin P, Chen Z, Lu X. Synthesis, properties, and bishomoaromaticity of the first tetrahalogenated derivative of a 1, 5-diphosphadithiatetrazocine: a combined experimental and computational investigation. Inorganic Chemistry 2010;49(8):3810-3815. |
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Faust JJ, Zhang W, Chen Y, Capco DG. Alpha-Fe(2)O(3) elicits diameter-dependent effects during exposure to an in vitro model of the human placenta. Cell Biology and Toxicology 2014;30(1):31-53. |
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Gao X, Ishimura K, Nagase S, Chen Z. Dichlorocarbene addition to C60 from the trichloromethyl anion: carbene mechanism or Bingel mechanism? Journal of Physical Chemistry A 2009;113(15):3673-3676. |
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Gao X, Wang L, Ohtsuka Y, Jiang D-E, Zhao Y, Nagase S, Chen Z. Oxidation unzipping of stable nanographenes into joint spin-rich fragments. Journal of the American Chemical Society 2009;131(28):9663-9669. |
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Gao X, Jian D-E, Zhao Y, Nagase S, Zhang S, Chen Z. Theoretical insights into the structures of graphene oxide and its chemical conversions between graphene. Journal of Computational and Theoretical Nanoscience 2011;8(12):2406-2422. |
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Jiang D-E, Chen W, Whetten RL, Chen Z. What protects the core when the thiolated Au cluster is extremely small? Journal of Physical Chemistry C 2009;113(39):16983-16987. |
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Jin P, Hao C, Gao Z, Zhang SB, Chen Z. Endohedral metalloborofullerenes La2@B80 and Sc3N@B80: a density functional theory prediction. Journal of Physical Chemistry A 2009;113(43):11613-11618. |
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Jin P, Li FY, Riley K, Lenoir D, Schleyer PVR, Chen ZF. What is the preferred structure of the Meisenheimer-Wheland complex between sym-triaminobenzene and 4,6-dinitrobenzofuroxan? Journal of Organic Chemistry 2010;75(11):3761-3765. |
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Jin P, Zhou Z, Hao C, Gao Z, Tan K, Lu X, Chen Z. NC unit trapped by fullerenes: a density functional theory study on Sc3NC@C2n (2n = 68, 78 and 80). Physical Chemistry Chemical Physics 2010;12(39):12442-12449. |
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Jin P, Chen Y, Zhang SB, Chen Z. Interactions between Al12X (X = Al, C, N and P) nanoparticles and DNA nucleobases/base pairs: implications for nanotoxicity. Journal of Molecular Modeling 2012;18(2):559-568. |
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Kalive M, Zhang W, Chen Y, Capco DG. Human intestinal epithelial cells exhibit a cellular response indicating a potential toxicity upon exposure to hematite nanoparticles. Cell Biology and Toxicology 2012;28(5):343-368. |
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Lee K, Kim Y-H, Sun YY, West D, Zhao Y, Chen Z, Zhang SB. Hole-mediated hydrogen spillover mechanism in metal-organic frameworks. Physical Review Letters 2010;104(23):236101. |
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Li B, Shu CY, Lu X, Dunsch L, Chen ZF, Dennis TJS, Shi ZQ, Jiang L, Wang TS, Xu W, Wang CR. Addition of carbene to the equator of C70 to produce the most stable C71H2 isomer: 2 aH-2(12)a-homo(C70-D5h(6))[5,6]fullerene. Angewandte Chemie International Edition 2010;49(5):962-966. |
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Li F, Zhao J, Chen Z. Hydrogen storage behavior of one-dimensional TiBx chains. Nanotechnology 2010;21(13):134006. |
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Li K, Zhang W, Huang Y, Chen Y. Aggregation kinetics of CeO2 nanoparticles in KCl and CaCl2 solutions: measurements and modeling. Journal of Nanoparticle Research 2011;13(12):6483-6491. |
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Li K, Chen Y, Zhang W, Pu Z, Jiang L, Chen Y. Surface interactions affect the toxicity of engineered metal oxide nanoparticles toward Paramecium. Chemical Research in Toxicology 2012;25(8):1675-1681. |
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Li K, Chen Y. Evaluation of DLVO interaction between a sphere and a cylinder. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2012;415:218-229. |
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Li K, Chen Y. Effect of natural organic matter on the aggregation kinetics of CeO2 nanoparticles in KCl and CaCl2 solutions: measurements and modeling. Journal of Hazardous Materials 2012;209-210:264-270. |
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Li K, Zhang W, Chen Y. Quantum dot binding to DNA: single-molecule imaging with atomic force microscopy. Biotechnology Journal 2013;8(1):110-116. |
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Li K, Zhao X, Hammer BK, Du S, Chen Y. Nanoparticles inhibit DNA replication by binding to DNA: modeling and experimental validation. ACS Nano 2013;7(11):9664-9674. |
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Li K, Chen Y. Examination of nanoparticle-DNA binding characteristics using single-molecule imaging atomic force microscopy. Journal of Physical Chemistry C 2014;118(25):13876-13882. |
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Li M, Li Y, Zhou Z, Shen P, Chen Z. Ca-coated boron fullerenes and nanotubes as superior hydrogen storage materials. Nano Letters 2009;9(5):1944-1948. |
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Li Y, Zhou Z, Shen P, Chen Z. Spin gapless semiconductor-metal-half-metal properties in nitrogen-doped zigzag graphene nanoribbons. ACS Nano 2009;3(7):1952-1958. |
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Li Y, Zhou Z, Shen P, Zhang SB, Chen Z. Computational studies on hydrogen storage in aluminum nitride nanowires/tubes. Nanotechnology 2009;20(21):215701. |
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Li Y, Zhou Z, Chen Y, Chen Z. Do all wurtzite nanotubes prefer faceted ones? Journal of Chemical Physics 2009;130(20):204706. |
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Li Y, Zhou Z, Shen P, Chen Z. Two-dimensional polyphenylene: experimentally available porous graphene as hydrogen purification membrane. Chemical Communications 2010;46(21):3672-3674. |
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Li Y, Zhou Z, Zhang S, Chen Z. MoS2 nanoribbons: high stability and unusual electronic and magnetic properties. Journal of the American Chemical Society 2008;130(49):16739-16744. |
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Li Y, Zhou Z, Shen P, Chen Z. Structural and electronic properties of graphane nanoribbons. Journal of Physical Chemistry C 2009;113(33):15043-15045. |
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Li Y, Zhou Z, Yu G, Chen W, Chen Z. CO catalytic oxidation on iron-embedded graphene: computational quest for low-cost nanocatalysts. Journal of Physical Chemistry C 2010;114(14):6250-6254. |
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Li Y, Zhou Z, Jin P, Chen Y, Zhang SB, Chen Z. Achieving ferromagnetism in single-crystalline ZnS wurtzite nanowires via chromium doping. Journal of Physical Chemistry C 2010;114(28):12099-12103. |
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Li Y, Zhang W, Niu JF, Chen Y. Mechanism of photogenerated reactive oxygen species and correlation with the antibacterial properties of engineered metal-oxide nanoparticles. ACS Nano 2012;6(6):5164-5173. |
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Li Y, Zhang W, Li K, Yao Y, Niu J, Chen Y. Oxidative dissolution of polymer-coated CdSe/ZnS quantum dots under UV irradiation: mechanisms and kinetics. Environmental Pollution 2012;164:259-266. |
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Li Y, Zhang W, Niu J, Chen Y. Surface-coating-dependent dissolution, aggregation, and reactive oxygen species (ROS) generation of silver nanoparticles under different irradiation conditions. Environmental Science & Technology 2013;47(18):10293-10301. |
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Liu C, Alwarappan S, Chen Z, Kong X, Li C-Z. Membraneless enzymatic biofuel cells based on graphene nanosheets. Biosensors & Bioelectronics 2010;25(7):1829-1833. |
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Liu C, Chen Z, Li C-Z. Surface engineering of graphene-enzyme nanocomposites for miniaturized biofuel cell. IEEE Transactions on Nanotechnology 2011;10(1):59-62. |
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Liu L, Wang L, Gao J, Zhao J, Gao X, Chen Z. Amorphous structural models for graphene oxides. Carbon 2012;50(4):1690-1698. |
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Sun L, Li Y, Li Z, Li Q, Zhou Z, Chen Z, Yang J, Hou JG. Electronic structures of SiC nanoribbons. Journal of Chemical Physics 2008;129(17):174114. |
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Sun YY, Lee K, Wang L, Kim Y-H, Chen W, Chen Z, Zhang SB. Accuracy of density functional theory methods for weakly bonded systems: the case of dihydrogen binding on metal centers. Physical Review B 2010;82(7):073401. |
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Tang Q, Li Y, Zhou Z, Chen Y, Chen Z. Tuning electronic and magnetic properties of wurtzite ZnO nanosheets by surface hydrogenation. ACS Applied Materials & Interfaces 2010;2(8):2442-2447. |
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Wang L, Zhao J, Zhou Z, Zhang SB, Chen Z. First-principles study of molecular hydrogen dissociation on doped Al12X (X = B, Al, C, Si, P, Mg, and Ca) clusters. Journal of Computational Chemistry 2009;30(15):2509-2514. |
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Wang L, Lee K, Sun Y-Y, Lucking M, Chen Z, Zhao JJ, Zhang SB. Graphene oxide as an ideal substrate for hydrogen storage. ACS Nano 2009;3(10):2995-3000. |
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Wang L, Zhao J, Li F, Chen Z. Boron fullerenes with 32-56 atoms: irregular cage configurations and electronic properties. Chemical Physics Letters 2010;501(1-3):16-19. |
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Wang L, Sun YY, Lee K, West D, Chen ZF, Zhao JJ, Zhang SB. Stability of graphene oxide phases from first-principles calculations. Physical Review B 2010;82(16):161406. |
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Wu Y-B, Jiang J-L, Li H, Chen Z, Wang Z-X. A bifunctional strategy towards experimentally (synthetically) attainable molecules with planar tetracoordinate carbons. Physical Chemistry Chemical Physics 2010;12(1):58-61. |
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Zhang C-G, Zhang R, Wang Z-X, Zhou Z, Zhang SB, Chen Z. Ti-substituted boranes as hydrogen storage materials: a computational quest for the ideal combination of stable electronic structure and optimal hydrogen uptake. Chemistry-A European Journal 2009;15(24):5910-5919. |
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Zhang G, Zhang W, Wang P, Minakata D, Chen Y, Crittenden J. Stability of an H(2)-producing photocatalyst (Ru/(CuAg)(0.15)In(0.3)Zn(1.4)S(2)) in aqueous solution under visible light irradiation. International Journal of Hydrogen Energy 2013;38(3):1286-1296. |
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Zhang G, Zhang W, Minakata D, Chen Y, Crittenden J, Wang P. The pH effects on H(2) evolution kinetics for visible light water splitting over the Ru/(CuAg)(0.15)In(0.3)Zn(1.4)S(2) photocatalyst. International Journal of Hydrogen Energy 2013;38(27):11727-11736. |
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Zhang G, Zhang W, Crittenden J, Minakata D, Chen Y, Wang P. Effects of inorganic electron donors in photocatalytic hydrogen production over Ru/(CuAg)(0.15)In(0.3)Zn(1.4)S(2) under visible light irradiation. Journal of Renewable and Sustainable Energy 2014;6(3):033131. |
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Zhang G, Zhang W, Minakata D, Wang P, Chen Y, Crittenden J. Efficient photocatalytic H(2) production using visible-light irradiation and (CuAg)(x)In(2x)Zn(2(1-2x))S(2) photocatalysts with tunable band gaps. International Journal of Energy Research 2014;38(12):1513-1521. |
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Zhang Q, Yue S, Lu X, Chen Z, Huang R, Zheng L, von Rague Schleyer P. Homoconjugation/homoaromaticity in main group inorganic molecules. Journal of the American Chemical Society 2009;131(28):9789-9799. |
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Zhang W, Kalive M, Capco DG, Chen Y. Adsorption of hematite nanoparticles onto Caco-2 cells and the cellular impairments: effect of particle size. Nanotechnology 2010;21(35):355103. |
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Zhang W, Yao Y, Li K, Huang Y, Chen Y. Influence of dissolved oxygen on aggregation kinetics of citrate-coated silver nanoparticles. Environmental Pollution 2011;159(12):3757-3762. |
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Zhang W, Stack AG, Chen Y. Interaction force measurement between E. coli cells and nanoparticles immobilized surfaces by using AFM. Colloids and Surfaces B: Biointerfaces 2011;82(2):316-324. |
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Zhang W, Yao Y, Chen Y. Imaging and quantifying the morphology and nanoelectrical properties of quantum dot nanoparticles interacting with DNA. Journal of Physical Chemistry C 2011;115(3):599-606. |
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Zhang W, Rittman B, Chen Y. Size effects on adsorption of hematite nanoparticles on E. coli cells. Environmental Science & Technology 2011;45(6):2172-2178. |
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Zhang W, Yao Y, Sullivan N, Chen Y. Modeling the primary size effects of citrate-coated silver nanoparticles on their ion release kinetics. Environmental Science & Technology 2011;45(10):4422-4428. |
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Zhang W, Crittenden J, Li K, Chen Y. Attachment efficiency of nanoparticle aggregation in aqueous dispersions: modeling and experimental validation. Environmental Science & Technology 2012;46(13):7054-7062. |
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Zhang W, Hughes J, Chen Y. Impacts of hematite nanoparticle exposure on biomechanical, adhesive, and surface electrical properties of Escherichia coli cells. Applied and Environmental Microbiology 2012;78(11):3905-3915. |
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Zhang W, Li Y, Niu J, Chen Y. Photogeneration of reactive oxygen species on uncoated silver, gold, nickel, and silicon nanoparticles and their antibacterial effects. Langmuir 2013;29(15):4647-4651. |
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Zhang W, Chen Y. Experimental determination of conduction and valence bands of semiconductor nanoparticles using Kelvin probe force microscopy. Journal of Nanoparticle Research 2013;15(1):1334 (4 pp.). |
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Zhang Y, Chen Y, Westerhoff P, Crittenden J. Impact of natural organic matter and divalent cations on the stability of aqueous nanoparticles. Water Research 2009;43(17):4249-4257. |
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Zhao J, Wang L, Li F, Chen Z. B80 and other medium-sized boron clusters: core-shell structures, not hollow cages. Journal of Physical Chemistry A 2010;114(37):9969-9972. |
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Zhao J, Chen Z. A special issue on structures, properties, and applications of nanomaterials: a computational exploration. Journal of Computational and Theoretical Nanoscience 2011;8(12):2395-2397. |
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Zhou Z, Li Y, Liu L, Chen Y, Zhang SB, Chen Z. Size- and surface-dependent stability, electronic properties, and potential as chemical sensors: computational studies on one-dimensional ZnO nanostructures. Journal of Physical Chemistry C 2008;112(36):13926-13931. |
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Supplemental Keywords:
metal oxides, nanoparticles, cell, biological fate, toxicity, quantum calculation, model, Quantitative Structure Activity Relationships (QSARs)Progress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.