Grantee Research Project Results
2008 Progress Report: Assessment of Perinatal PBDE Exposure and Related Child Behavioral and Cognitive Developmental Effects
EPA Grant Number: R832736Title: Assessment of Perinatal PBDE Exposure and Related Child Behavioral and Cognitive Developmental Effects
Investigators: Daniels, J L , Savitz, David A. , Herring, Amy H. , Siega-Riz, Anna Maria , Goldman, B , Evenson, Kelly
Institution: University of North Carolina at Chapel Hill
EPA Project Officer: Callan, Richard
Project Period: March 15, 2006 through March 14, 2009 (Extended to March 14, 2011)
Project Period Covered by this Report: March 15, 2008 through March 14,2009
Project Amount: $749,990
RFA: Early Indicators of Environmentally Induced Disease (2004) RFA Text | Recipients Lists
Research Category:
Objective:
We will assess correlation in the classification of PBDE exposure between the home exposure assessment, levels in breast milk, and levels in house dust. We also will identify factors in the home and diet that predict maternal PBDE levels in breast milk. We will estimate the change in cognitive and behavioral developmental scores relative to total PBDE level and PBDE composition using random effects models and generalized estimating equations, accounting for the correlation in development over time and adjusting for important confounding factors. This study will efficiently estimate contemporary PBDE levels from the largest human sample to date in North America, correlate household sources of exposure with levels measured in dust and in humans, and provide the first results of an investigation of the effects of PBDEs on early human development. These data will provide information about potential risks to development associated with exposure to PBDEs.
Progress Summary:
Data collection for the study has been administered in the field at four subsequent time points, 3 months, 12 months, 24 months, and 36 months postpartum. Breast milk specimens have been analyzed by the CDC laboratory (n = 389). Analysis of first- and third-year postpartum household dust specimens is planned by the CDC laboratory. Data collection was completed in December 2008, with the completion of 206 environmental questionnaires and 341 developmental assessments at age 36 months. These environmental data have been merged with existing data from the PIN pregnancy and PIN postpartum studies. Analyses and manuscript preparation are underway.
Future Activities:
Data analysis and preparation of presentations and publications during 2009 and 2010.
Journal Articles on this Report : 6 Displayed | Download in RIS Format
| Other project views: | All 6 publications | 6 publications in selected types | All 6 journal articles |
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Adgent MA, Hoffman K, Goldman BD, Sjodin A, Daniels JL. Brominated flame retardants in breast milk and behavioural and cognitive development at 36 months. Paediatric and Perinatal Epidemiology 2014;28(1):48-57. |
R832736 (2008) |
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Daniels JL, Pan IJ, Jones R, Anderson S, Patterson Jr DG, Needham LL, Sjodin A. Individual characteristics associated with PBDE levels in U.S. human milk samples. Environmental Health Perspectives 2010;118(1):155-160. |
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Hoffman K, Adgent M, Goldman BD, Sjodin A, Daniels JL. Lactational exposure to polybrominated diphenyl ethers and its relation to social and emotional development among toddlers. Environmental Health Perspectives 2012;120(10):1438-1442. |
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Hoffman K, Mendez M, Siega-Riz AM, Herring AH, Sjodin A, Daniels JL. Lactational exposure to polybrominated diphenyl ethers and its relation to early childhood anthropometric measurements. Environmental Health Perspectives 2016;124(10):1656-1661. |
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Pan IJ, Daniels JL, Goldman BD, Herring AH, Siega-Riz AM, Rogan WJ. Lactational exposure to polychlorinated biphenyls, dichlorodiphenyltrichloroethane, and dichlorodiphenyldichloroethylene and infant neurodevelopment: an analysis of the pregnancy, infection, and nutrition babies study. Environmental Health Perspectives 2009;117(3):488-494. |
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Pan IJ, Daniels JL, Herring AH, Rogan WJ, Siega-Riz AM, Goldman BD, Sjodin A. Lactational exposure to polychlorinated biphenyls, dichlorodiphenyltrichloroethane, and dichlorodiphenyldichloroethylene and infant growth: an analysis of the Pregnancy, Infection, and Nutrition Babies Study. Paediatric and Perinatal Epidemiology 2010;24(3):262-271. |
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Supplemental Keywords:
epidemiology, environmental health, exposure assessment, longitudinal, human milk biomarkers, PBDE, persistent organic pollutants;, RFA, Health, Scientific Discipline, INTERNATIONAL COOPERATION, ENVIRONMENTAL MANAGEMENT, Health Risk Assessment, Environmental Policy, Children's Health, Biochemistry, Risk Assessment, behavioral effects, Human Health Risk Assessment, maternal exposure, childhood learning, perinatal exposure, flame retardants, PBDE, developmental neurotoxicity, assessment of exposure, cognitive development, developmental disordersProgress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.