Grantee Research Project Results
Environmental Factors in the Etiology of Autism; Analytic Biomakers (xenobiotic) Core
EPA Grant Number: R829388C001Subproject: this is subproject number 001 , established and managed by the Center Director under grant R829388
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: UC Davis Center for Children's Environmental Health and Disease Prevention
Center Director: Van de Water, Judith
Title: Environmental Factors in the Etiology of Autism; Analytic Biomakers (xenobiotic) Core
Investigators: Hammock, Bruce , German, Bruce , Lango, Jozsef , Watkins, Steve
Current Investigators: Hammock, Bruce , German, Bruce , Lango, Jozsef , Dettmer, Katja , Green, Peter
Institution: University of California - Davis
EPA Project Officer: Aja, Hayley
Project Period: September 30, 2001 through September 29, 2002
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2001) RFA Text | Recipients Lists
Research Category: Human Health , Children's Health
Objective:
The two major goals of this core are to develop strategies to profile xenobiotics of concern to childhood neurodevelopment in biological fluids and provide support in metabolomics. The long-term approach is to establish a horizontally integrated database from the genome through the autistic phenotype to aid in developing and testing hypotheses regarding the disorder. Thus the core provides established analytical support for xenobiotic and proteomic profiling, and is currently developing tools to study the metabolome.
Our specific aims are: I.) Determine xenobiotics in serum, urine and food; II.) Determine levels of nutritional and structural lipids in serum samples; III.) Provide general analytical support for the project including the development of methods for possible biomarkers that are considered important.
Publications and Presentations:
Publications have been submitted on this subproject: View all 20 publications for this subproject | View all 175 publications for this centerJournal Articles:
Journal Articles have been submitted on this subproject: View all 18 journal articles for this subproject | View all 157 journal articles for this centerSupplemental Keywords:
Autism, metabolomics, lipids, proteomics, xenobiotics,, RFA, Health, Scientific Discipline, PHYSICAL ASPECTS, ENVIRONMENTAL MANAGEMENT, Toxicology, Health Risk Assessment, Chemistry, Epidemiology, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Disease & Cumulative Effects, Physical Processes, Children's Health, genetic susceptability, Biology, Risk Assessment, chemical exposure, neurotoxic, xenobiotics, biomarkers, gene-environment interaction, neurodevelopment, pesticides, exposure, halogenated aromatics, children, neurobehavioral, neurodevelopmental, neurotoxicity, etiology, susceptibility, human exposure, neurobehavioral effects, autism, biological markers, mechanisms, exposure assessment, neurological development, biomarker, synergistic interactions, mercurialsProgress and Final Reports:
Main Center Abstract and Reports:
R829388 UC Davis Center for Children's Environmental Health and Disease Prevention Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R829388C001 Environmental Factors in the Etiology of Autism; Analytic Biomakers (xenobiotic) Core
R829388C002 Environmental Factors in the Etiology of Autism; Cell Activation/Signaling Core
R829388C003 Environmental Factors in the Etiology of Autism; Molecular Biomakers Core
R829388C004 Environmental Factors in the Etiology of Autism; Childhood Autism Risks from Genetics and the Environment (The CHARGE Study)
R829388C005 Environmental Factors in the Etiology of Autism; Animal Models of Autism
R829388C006 Environmental Factors in the Etiology of Autism; Molecular and Cellular Mechanisms of Autism
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
18 journal articles for this subproject
Main Center: R829388
175 publications for this center
157 journal articles for this center