Grantee Research Project Results
2004 Progress Report: Effect of Diesel Exhaust Particulate Exposures on Endothelial Function in Humans: The Role of Oxidative Stress
EPA Grant Number: R830954Title: Effect of Diesel Exhaust Particulate Exposures on Endothelial Function in Humans: The Role of Oxidative Stress
Investigators: Kaufman, Joel D. , Sheppard, Lianne (Elizabeth) A. , Koenig, Jane Q. , Larson, Timothy V. , Trenga, Carol , Leotta, Daniel , Gill, Edward , Sullivan, Jeff , Yost, Michael , Chandler, Wayne
Institution: University of Washington
EPA Project Officer: Chung, Serena
Project Period: August 15, 2003 through August 14, 2006 (Extended to August 14, 2008)
Project Period Covered by this Report: August 15, 2003 through August 14, 2004
Project Amount: $1,036,972
RFA: Airborne Particulate Matter Health Effects: Cardiovascular Mechanisms (2002) RFA Text | Recipients Lists
Research Category: Particulate Matter , Air Quality and Air Toxics , Human Health , Air
Objective:
Diesel exhaust particles are a substantial and biologically active fraction of urban fine particulate air pollution, which is associated with increases in cardiovascular morbidity and mortality. This project addresses the overall hypothesis that ambient fine particulate matter exerts cardiovascular health effects via alteration of endothelial homeostasis, through a mechanism mediated by oxidative stress. The objectives of this research project are to determine if: (1) exposure to inhaled diesel exhaust (DE) particulate is associated with endothelial dysfunction in a concentration-related manner; (2) exposure to inhaled DE is associated with evidence of systemic oxidative stress; and (3) antioxidant supplementation blunts the DE effect on endothelial function. Controlled human inhalation exposure to diesel exhaust is used as a model to address the objectives.
Progress Summary:
The diesel exposure facility is functioning according to specifications. A pilot study was completed that demonstrated logistical success of study plans, as well as tolerability of exposures.
Future Activities:
Experiments to evaluate concentration-related effects of DE on endothelial function and oxidative stress will be completed in Year 2 of the project.
Journal Articles:
No journal articles submitted with this report: View all 33 publications for this projectSupplemental Keywords:
ambient air, human health, dose-response, mobile sources, diesel exhaust, particulate matter, PM, cardiovascular health, air pollution, health effects,, RFA, Health, Air, Scientific Discipline, HUMAN HEALTH, Susceptibility/Sensitive Population/Genetic Susceptibility, Health Risk Assessment, Risk Assessments, particulate matter, Biology, genetic susceptability, mobile sources, Environmental Chemistry, Exposure, air toxics, air quality, diesel exhaust, inhaled, sensitive populations, environmental hazard exposures, inhaled pollutants, fine particles, lung inflammation, mortality, oxidant gas, engine exhaust, co-pollutants, acute lung injury, endothelial function, DEP, cardiopulmonary responses, morbidity, particulate exposure, chronic obstructive pulmonary disease, acute exposure, Acute health effects, cardiotoxicity, copollutant exposures, airway epithelial cells, diesel exhaust particulate, chronic health effects, susceptible subpopulations, toxics, concentrated particulate matter, heart rate, air contaminant exposure, atmospheric particulate matter, air pollution, cardiopulmonary, cardiovascular disease, highrisk groups, biomarker, human susceptibility, airborne urban contaminants, ambient particle pollution, automotive exhaust, cardiopulmonary response, PM 2.5, diesel exhaust particlesProgress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.