Grantee Research Project Results
1999 Progress Report: Genetic Susceptibility to the Effects of Aromatic Solvents on Reproductive Health
EPA Grant Number: R825818Title: Genetic Susceptibility to the Effects of Aromatic Solvents on Reproductive Health
Investigators: Xu, Xiping , Ryan, Louise , Chen, Dafang , Christiani, David , Wang, Lihua , Smith, Thomas
Institution: Harvard University
EPA Project Officer: Aja, Hayley
Project Period: February 1, 1998 through January 31, 2001
Project Period Covered by this Report: February 1, 1998 through January 31, 1999
Project Amount: $792,308
RFA: Issues in Human Health Risk Assessment (1997) RFA Text | Recipients Lists
Research Category: Human Health
Objective:
The objective of the research is to assess the impact of gene-aromatic solvent interaction on adverse reproductive outcomes, including menstrual disturbance, infertility, spontaneous abortion, preterm delivery, and low birth weight. Specifically, using resources from a large, well-characterized cohort study, whether the risk of adverse reproductive outcomes associated with aromatic solvent exposure is elevated in individuals with relevant variants of one of the following nine genes: GSTM1, GSTT1, CYP1A1, CYP2D6, CYP2E1, NAT2, NQO1, ALDH2, and EPHX will be investigated.Progress Summary:
Research has focused on benzene exposure and two susceptibility genes, CYP1A1 and GSTT1 (known to be responsible for the metabolism and detoxification of organic solvents), in relation to gestational age. The analysis included 542 female petrochemical workers (302 nonexposed and 240 benzene exposed) who gave live singleton births at a staff hospital. Benzene exposure was significantly associated with shortened gestation, even at a level at least five times lower than that of the Occupational Safety and Health Administration (OSHA) limit; however, the association was significantly modified by maternal genotype. Among nonexposed, genetic susceptibility alone did not confer significant adverse effect.Future Activities:
Further activities will involve assessing the role of genetic susceptibility in the evaluation of reproductive toxins.Journal Articles on this Report : 2 Displayed | Download in RIS Format
| Other project views: | All 6 publications | 6 publications in selected types | All 6 journal articles |
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Wang XB, Chen DF, Niu TH, Wang ZX, Wang LH, Ryan L, Smith T, Christiani DC, Zuckerman B, Xu XP. Genetic susceptibility to benzene and shortened gestation: evidence of gene-environment interaction. American Journal of Epidemiology 2000;152(8):693-700. |
R825818 (1999) R825818 (Final) |
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Wang X, Wang M, Niu T, Chen CZ, Xu X. Microsomal epoxide hydrolase (EPHX) polymorphism and risk of spontaneous abortion. Epidemiology 1998;9(5):540-544. |
R825818 (1999) R825818 (Final) |
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Supplemental Keywords:
aromatic solvents, toxins, menstrual disturbance, spontaneous abortion, infertility, preterm delivery, low birth weight, gene-solvent interaction., Health, Scientific Discipline, Air, Geographic Area, Toxics, International, Risk Assessments, Chemistry, HAPS, Environmental Chemistry, 33/50, air toxics, Genetics, Benzene (including benzene from gasoline), toxic environmental contaminants, benzene, human exposure, genetic analysis, Toluene, genetic susceptibility, developmental effects, aromatic solvents, China, reproductive health, biomarker, blood samples, StyreneProgress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.