Grantee Research Project Results
2003 Progress Report: Longitudinal Study of Children's Exposure to Permethrin
EPA Grant Number: R829397Title: Longitudinal Study of Children's Exposure to Permethrin
Investigators: Hu, Ye A. , Akland, Gerald G. , Raymer, James H.
Current Investigators: Raymer, James H. , Hu, Ye A. , Michael, L. C. , Studabaker, W.
Institution: Desert Research Institute
EPA Project Officer: Aja, Hayley
Project Period: February 18, 2002 through February 17, 2005 (Extended to July 17, 2006)
Project Period Covered by this Report: February 18, 2003 through February 17, 2004
Project Amount: $754,664
RFA: Children's Vulnerability to Toxic Substances in the Environment (2001) RFA Text | Recipients Lists
Research Category: Environmental Justice , Human Health , Children's Health
Objective:
The objectives of this research project are to: (1) investigate the time course of the redistribution of pyrethroid pesticides in various media following application and factors affecting the redistribution; (2) investigate the functional relationships across time between environmental media, personal measurements, and biological media; (3) estimate aggregate exposure after application and the importance of each exposure pathway; and (4) investigate the difference between the time course of pyrethroid pesticide metabolism in adults and children.
Progress Summary:
To achieve the objectives, we recruited 15 homes that use pyrethroid pesticides indoors and have stay-home children younger than 3 years old. Each of the homes has been followed intensively for 7 days after application. Then, they were followed once a week in the first month after application and every other month in the following 11 months. Environmental samples, food samples, personal samples (hand wipes, whole body dosimeter) and urine samples have been collected from children and one stay-home parent. The samples have been analyzed in our laboratory following standard operating procedures and analysis protocols. Data will be analyzed and models developed to meet the objectives.
The focus of Year 2 of the project was field sample collection. We have successfully enrolled 15 subjects, meeting our original goal. Thirteen subjects finished their 6-month followup, and 2 subjects finished 12-month followup. Only one subject dropped out of the study because the family moved after finishing 6 months of sampling. Popular pyrethroids used in the homes were cypermethrin, deltamethrin, and permethrin, followed by cyfluthrin and cyhalothrin. In two homes, two pyrethroids were used jointly. Seven of the homes were treated by professional applicators, and six homes were treated by the owner. Most homes were treated multiple times during the follow-up period. A portion of hand wipes and surface wipes have been extracted and analyzed. Target compounds were found in most of the surface wipes. In homes that applied the target compounds, the levels were substantial. The highest mean loading was found for cis-permethrin (45 ng/cm2) and trans-permethrin (56 ng/cm2).
Future Activities:
We will complete field sample collection, sample analysis, and data analysis during Year 3 of the project. We will start descriptive statistical analysis when a sufficient number of samples have been analyzed. Final statistical analysis and modeling will be performed when all of the samples have been analyzed and a database has been established.
Journal Articles on this Report : 1 Displayed | Download in RIS Format
Other project views: | All 9 publications | 4 publications in selected types | All 4 journal articles |
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Type | Citation | ||
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Hu Y, Beach J, Raymer J, Gardner M. Disposable diaper to collect urine samples from young children for pyrethroid pesticide studies. Journal of Exposure Analysis and Environmental Epidemiology 2004;14(5):378-384. |
R829397 (2002) R829397 (2003) R829397 (2004) R829397 (Final) |
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Supplemental Keywords:
pyrethroid pesticides, children, longitudinal, disposable diapers, health, biology, chemistry, children's health, disease and cumulative effects, health risk assessment, physical processes, risk assessment, susceptibility, sensitive population, genetic susceptibility, toxicology, body dosimeter, children, exposure, exposure assessment, exposure pathways, functional relationships, human exposure, human health risk, longitudinal study, metabolism, multipathway study, perinatal exposure, permethrin, pesticides, exposure modeling., RFA, Scientific Discipline, Health, Health Risk Assessment, Chemistry, Risk Assessments, Disease & Cumulative Effects, Children's Health, Biology, multi-pathway study, permethrin, pesticides, functional relationships, urinary metabolite, exposure, children, longitudinal study, body dosimeter, human exposure, exposure pathways, metabolism, exposure assessmentProgress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.