Grantee Research Project Results

Pesticide Exposure Pathways Research Project

EPA Grant Number: R826886C004
Subproject: this is subproject number 004 , established and managed by the Center Director under grant R826886
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Center for Air, Climate, and Energy Solutions
Center Director: Robinson, Allen
Title: Pesticide Exposure Pathways Research Project
Investigators: Faustman, Elaine
Institution: University of Washington
EPA Project Officer: Callan, Richard
Project Period: August 1, 1998 through December 31, 2003
Project Amount: Refer to main center abstract for funding details.
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health

Objective:

In this project, the role of age dependent differences in paraoxonase metabolism of organophosphate and metabolic polymorphisms on organophosphate toxicity will be evaluated. Thus, both age and genetic polymorphism will be evaluated in the context of potential factors impacting the susceptibility of children to organophosphate neurodevelopmental toxicity. Research from this project will provide the basis for child specific pharmacokinetic models that the Exposure Assessment Facility Core will develop for organophosphate pesticides. This project, like the other laboratory based project, will provide an improved scientific basis for our risk assessments for children.

Field-Based Studies

The two field based studies address a second key risk assessment issue for children, that of understanding the pathways and amounts of pesticides to which children are exposed.

Publications and Presentations:

Publications have been submitted on this subproject: View all 15 publications for this subproject | View all 89 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 9 journal articles for this subproject | View all 75 journal articles for this center

Supplemental Keywords:

children, health, pesticide, exposure, neurodevelopment, organophosphates., RFA, Scientific Discipline, Health, Toxics, Environmental Chemistry, Health Risk Assessment, pesticides, Risk Assessments, Biochemistry, Children's Health, health effects, pesticide exposure, organophosphates, biological response, environmental risks, neurodevelopment, children, Human Health Risk Assessment, neurotoxicity, assessment of exposure, susceptibility, toxicity, paraoxonase polymorphism, human exposure, environmental health hazard, growth & development, neurological development

Progress and Final Reports:

Main Center Abstract and Reports:

R826886 Center for Air, Climate, and Energy Solutions

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R826886C001 Molecular Mechanisms of Pesticide-Induced Developmental Toxicity
R826886C002 Genetic Susceptibility to Pesticides (Paraoxonase Polymorphism or PON1 Study)
R826886C003 Community-Based Participatory Research Project
R826886C004 Pesticide Exposure Pathways Research Project

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.