Grantee Research Project Results
Growth and Development/Evaluation of Carcinogenic Risks
EPA Grant Number: R827027C002Subproject: this is subproject number 002 , established and managed by the Center Director under grant R827027
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Water Environment and Reuse Foundation's National Center for Resource Recovery and Nutrient Management
Center Director: Olabode, Lola
Title: Growth and Development/Evaluation of Carcinogenic Risks
Investigators: Perera, Frederica P.
Institution: Columbia University in the City of New York
EPA Project Officer: Callan, Richard
Project Period: August 1, 1998 through July 31, 2001 (Extended to October 31, 2004)
Project Amount: Refer to main center abstract for funding details.
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
The Research Project on Asthma is designed to achieve Specific Aim 2: to test the hypotheses a) that prenatal and/or postnatal exposure to home allergens (cockroach, house dust mite, and rodent) and ETS, as well as postnatal exposure to PM2.5 and diesel exhaust particulate (DEP), are significant contributors to risk of asthma, as indicated by related biomarkers and persistent wheezing, b) that the risk from home allergens is increased by co-exposure to the air pollutants (ETS, PM2.5 and DEP); and c) that impaired nutritional status (inadequate levels of antioxidants) heightens susceptibility to the pollutants. Project investigators will conduct an etioloic study of environmental and susceptibility factors in the same cohort of 400 infants and will also contribute to the intervention study. The Project will make use of all of the questionnaire data as well as the biomarker data on cotinine and antioxidants collected by the G&D Project. Additional exposures of interest (home allergens, PM2.5 and DEP, and N02 as a potential confounder) will be monitored and modeled. In addition, the Project will obtain measurements of infants' IgE (total and allergen specific) at birth and at 24 months, as well as measurements of lymphocyte proliferation and cytokines at birth. Mothers will be interviewed at serial time points to obtain information on their children's respiratory symptoms. The Co-investigators on this Project will also contribute to the Intervention Research Project by providing the clinical data on respiratory symptoms for the 120 participating infants at enrollment into the intervention (24 months postnatally) and at 30 and 36 months postnatally. They will also provide the IgE analyses at enrollment and at 36 months.Supplemental Keywords:
children, exposure, asthma, PM, particulate matter, ETS, allergen, infants., RFA, Health, Air, Scientific Discipline, Susceptibility/Sensitive Population/Genetic Susceptibility, Health Risk Assessment, Risk Assessments, Chemistry, particulate matter, Biology, genetic susceptability, Environmental Chemistry, Epidemiology, tropospheric ozone, Allergens/Asthma, Children's Health, indoor air, air toxics, Environmental Monitoring, epidemeology, health effects, Human Health Risk Assessment, infants, indoor air quality, childhood respiratory disease, disease, diesel exhaust, diesel exhaust particulates, environmental hazard exposures, sensitive populations, human health, maternal exposure, indoor environment, asthma triggers, asthma, airway inflammation, allergen, biological markers, copollutants, dust , stratospheric ozone, dust mites, respiratory, biological response, human exposure, nutrition, children, cockroaches, exposure, sensitive population, PM, dust mite, allergic response, children's vulnerablity, diesel particulates, toxics, home, assessment of exposure, human health risk, exposure assessment, inhalation, airway disease, PM 2.5Progress and Final Reports:
Main Center Abstract and Reports:
R827027 Water Environment and Reuse Foundation's National Center for Resource Recovery and Nutrient Management Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827027C001 Community-Based Intervention: Reducing Risks of Asthma
R827027C002 Growth and Development/Evaluation of Carcinogenic Risks
R827027C003 Research Project on Asthma
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.