Grantee Research Project Results
2015 Progress Report: Dynamical Systems Models Based on Energy Budgets for Ecotoxicological Impact Assessment
EPA Grant Number: R835797Title: Dynamical Systems Models Based on Energy Budgets for Ecotoxicological Impact Assessment
Investigators: Nisbet, Roger M. , Muller, Erik B , Whitehead, Andrew
Institution: University of California - Santa Barbara , University of California - Davis
EPA Project Officer: Aja, Hayley
Project Period: June 1, 2015 through May 31, 2018 (Extended to May 31, 2019)
Project Period Covered by this Report: June 1, 2015 through May 31,2016
Project Amount: $799,723
RFA: Systems-Based Research for Evaluating Ecological Impacts of Manufactured Chemicals (2014) RFA Text | Recipients Lists
Research Category: Chemical Safety for Sustainability
Objective:
The overarching aim of the research is to use theoretical and experimental methods, based on that Dynamic Energy Budget (DEB) models, to inform ecological risk assessment (ERA) by determining how the effects of exposure to chemical stressors are expressed across levels of biological organization. We aim to: (1) develop new modular DEB models with explicit feedbacks representing regulatory processes in response to toxicant exposure in an organism; (2) determine how genomic data on two model organisms (the waterflea Daphnia and the estuarine fish Fundulus) experiencing combined food and chemical stress relate to parameters in DEB models; (3) predict organismal and population "tipping points" caused by failure of physiological and population regulatory processes; (4) develop models of adaptation to stress in chronically polluted environments; and (5) evaluate the applicability of our findings to non-model organisms.
Progress Summary:
Future Activities:
Activities relating to objectives (1)-(3) will continue. Work on objective (2) will emphasize work on killifish (Fundulus spp.) that will support new theory for objective (4).
Journal Articles on this Report : 3 Displayed | Download in RIS Format
Other project views: | All 39 publications | 14 publications in selected types | All 13 journal articles |
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Miller RJ, Muller EB, Cole B, Martin T, Nisbet R, Bielmyer-Fraser GK, Jarvis TA, Keller AA, Cherr G, Lenihan HS. Photosynthetic efficiency predicts toxic effects of metal nanomaterials in phytoplankton. Aquatic Toxicology 2017;183:85-93. |
R835797 (2015) R835797 (2016) |
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Rohr JR, Salice CJ, Nisbet RM. The pros and cons of ecological risk assessment based on data from different levels of biological organization. Critical Reviews in Toxicology 2016;46(9):756-784. |
R835797 (2015) R835797 (2016) R835188 (Final) R835800 (2016) R835800 (2017) R835800 (2018) R835800 (2019) |
Exit Exit |
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Klanjscek T, Muller EB, Nisbet RM. Feedbacks and tipping points in organismal response to oxidative stress. Journal of Theoretical Biology 2016;404:361-374. |
R835797 (2015) R835797 (2016) |
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Supplemental Keywords:
Individual-based model, dynamic energy budget, DEB, DEBtox, adverse outcome pathways, metabolism, ecology, ecosystem, scaling, toxicsProgress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.