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Grantee Research Project Results

Advancing Toxicokinetics for Efficient and Robust Chemical Evaluations

EPA awards five academic research teams to develop New Approach Methods (NAMs) for evaluating chemical toxicokinetics to address gaps in ways to obtain data for informing chemical toxicokinetics and exposure-related factors.

Request for Applications closing date: September 24, 2019

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# Grant Number Abstract Principal Investigator Institution Grant Amount PROJECT PERIOD Project Start Date Project End Date Extended End Date State
<< STAR GRANTS AND STAR CENTERS >>
# Grant Number Abstract Principal Investigator Institution Grant Amount PROJECT PERIOD Project Start Date Project End Date Extended End Date State
1 R840027
Grant



Integrated blood brain barrier computational model development to predict doses of concern for compound linked neurotoxicity Knipp, Gregory
Sluka, James
Stratford, Robert  
Purdue University, Indiana University $790,441   August 01, 2020 -
May 08, 2025  
August 01, 2020   May 08, 2025     IN  
2 R840029
Grant



Toxicokinetic screening of zebrafish cytochrome P450 enzymes for in vitro-in vivo extrapolation Goldstone, Jared
Wilson, Joanna  
Woods Hole Oceanographic Institution, McMaster University $799,999   August 01, 2020 -
May 10, 2025  
August 01, 2020   May 10, 2025     MA  
3 R840031
Grant



Measuring Toxicokinetics for Organ-on-Chip Devices Hutson, Michael Shane
Markov, Dmitry
McCawley, Lisa J.  
Vanderbilt University $790,352   August 01, 2020 -
May 06, 2025  
August 01, 2020   May 06, 2025     TN  
4 R840032
Grant



Integrating tissue chips, rapid untargeted analytical methods and molecular modeling for toxicokinetic screening of chemicals, their metabolites and mixtures Rusyn, Ivan
Baker, Erin D.
Chiu, Weihsueh A  
Texas A & M University, North Carolina State University $799,993   August 01, 2020 -
May 02, 2025  
August 01, 2020   May 02, 2025     TX  
5 R840033
Grant



An in vitro-in silico hybrid approach for high-throughput estimation of trans-barrier permeability for chemical pollutants Li, Dingsheng
Bell, Thomas W
Earley, Yumei F
Li, Li  
University of Nevada - Reno $799,997   August 01, 2020 -
July 30, 2023
(Extended to July 30, 2024)  
August 01, 2020   July 30, 2023  
July 30, 2024  
NV  


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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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Last updated April 28, 2023
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