Grantee Research Project Results
Publications Details for Grant Number R834515C001
Endotoxin Exposure and Asthma in Children
RFA:
Children's Environmental Health and Disease Prevention Research Centers (with NIEHS) (2009)
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Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
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Abstract | Divergent effects of endotoxin and mold exposure on asthma exacerbations in the Childhood Asthma Management Program (CAMP). | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | Covar RA, Forssen A, Szefler SJ, Schwartz DA, Liu AH | Covar RA, Forssen A, Szefler SJ, Schwartz DA, Liu AH. Divergent effects of endotoxin and mold exposure on asthma exacerbations in the Childhood Asthma Management Program (CAMP). Journal of Allergy and Clinical Immunology 2014;133(2 Suppl):AB164. |
R834515 (2012) R834515 (2013) R834515 (2014) R834515 (2015) R834515 (Final) R834515C001 (2014) R834515C001 (2015) R834515C002 (2014) R834515C003 (2014) |
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Abstract | Accurate assessment of personal air pollutant exposures in inner-city asthmatic children. | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | Dutmer CM, Schiltz AM, Faino A, Rabinovitch N, Cho SH, Chartier RT, Rodes CE, Szefler SJ, Schwartz DA, Thornburg JW, Liu AH | Dutmer CM, Schiltz AM, Faino A, Rabinovitch N, Cho SH, Chartier RT, Rodes CE, Szefler SJ, Schwartz DA, Thornburg JW, Liu AH. Accurate assessment of personal air pollutant exposures in inner-city asthmatic children. Journal of Allergy and Clinical Immunology 2015;135(2 Suppl):AB165. |
R834515 (2015) R834515 (Final) R834515C001 (2014) R834515C001 (2015) R834515C002 (2014) R834515C003 (2014) |
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Abstract | Increased asthma severity associated with personal air pollutant exposures in inner-city asthmatic children. | AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | Dutmer CM, Schiltz AM, Faino A, Cho SH, Chartier RT, Rodes CE, Szefler SJ, Schwartz DA, Thornburg JW, Liu AH | Dutmer CM, Schiltz AM, Faino A, Cho SH, Chartier RT, Rodes CE, Szefler SJ, Schwartz DA, Thornburg JW, Liu AH. Increased asthma severity associated with personal air pollutant exposures in inner-city asthmatic children. American Journal of Respiratory and Critical Care Medicine 2015:191:A6268. |
R834515 (2014) R834515 (2015) R834515 (Final) R834515C001 (2014) R834515C001 (2015) R834515C002 (2014) R834515C003 (2014) |
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Abstract | Effect of postnatal ozone exposure on the developing lung. | AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | Gabehart K, Correll KA, Yang J, Collins ML, Loader JE, White CW, Dakhama A | Gabehart K, Correll KA, Yang J, Collins ML, Loader JE, White CW, Dakhama A. Effect of postnatal ozone exposure on the developing lung. American Journal of Respiratory and Critical Care Medicine 2011;183:A3242. |
R834515 (2013) R834515 (2014) R834515 (2015) R834515 (Final) R834515C001 (2014) R834515C002 (2014) R834515C002 (2015) R834515C003 (2014) |
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Abstract | Effect of ozone exposure on established allergic airway disease in mice. | AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | Gabehart K, Correll KA, Yang J, Loader JE, White CW, Dakhama A | Gabehart K, Correll KA, Yang J, Loader JE, White CW, Dakhama A. Effect of ozone exposure on established allergic airway disease in mice. American Journal of Respiratory and Critical Care Medicine 2012;185:A4647. |
R834515 (2011) R834515 (2013) R834515 (2014) R834515 (2015) R834515 (Final) R834515C001 (2014) R834515C002 (2014) R834515C002 (2015) R834515C003 (2014) |
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Abstract | Postnatal ozone exposure enhances house dust mite induced airway hyperresponsiveness without increasing inflammation. | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | Gabehart K, Correll KA, Yang J, Collins ML, Loader JE, White CW, Dakhama A | Gabehart K, Correll KA, Yang J, Collins ML, Loader JE, White CW, Dakhama A. Postnatal ozone exposure enhances house dust mite induced airway hyperresponsiveness without increasing inflammation. Journal of Allergy and Clinical Immunology 2012;129(2 Suppl):AB204. |
R834515 (2011) R834515 (2013) R834515 (2014) R834515 (2015) R834515 (Final) R834515C001 (2014) R834515C002 (2014) R834515C002 (2015) R834515C003 (2014) |
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Abstract | Transcriptome profiling of the newborn mouse lung response to acute ozone exposure. | AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | Gabehart K, Correll KA, Leach S, Collins ML, Yang J, Loader JE, White CW, Dakhama A | Gabehart K, Correll KA, Leach S, Collins ML, Yang J, Loader JE, White CW, Dakhama A. Transcriptome profiling of the newborn mouse lung response to acute ozone exposure. American Journal of Respiratory and Critical Care Medicine 2013;187:A1184. |
R834515 (2013) R834515 (2014) R834515C001 (2014) R834515C002 (2014) R834515C002 (2015) R834515C003 (2014) |
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Abstract | Cluster analysis of an inner-city cohort of infant wheezers. | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | Reddy MB, Liu AH, Schiltz A, Forssen A, Klinnert MD | Reddy MB, Liu AH, Schiltz A, Forssen A, Klinnert MD. Cluster analysis of an inner-city cohort of infant wheezers. Journal of Allergy and Clinical Immunology 2014;133(2 Suppl):AB71. |
R834515 (2012) R834515 (2013) R834515 (2014) R834515 (2015) R834515 (Final) R834515C001 (2014) R834515C001 (2015) R834515C002 (2014) R834515C003 (2014) |
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Journal Article | Functional polymorphisms in the gene encoding macrophage migration inhibitory factor are associated with gram-negative bacteremia in older adults. | None | Das R, Subrahmanyan L, Yang IV, van Duin D, Levy R, Piecychna M, Leng L, Montgomery RR, Shaw A, Schwartz DA, Bucala R | Das R, Subrahmanyan L, Yang IV, van Duin D, Levy R, Piecychna M, Leng L, Montgomery RR, Shaw A, Schwartz DA, Bucala R. Functional polymorphisms in the gene encoding macrophage migration inhibitory factor are associated with gram-negative bacteremia in older adults. Journal of Infectious Diseases 2014;209(5):764-768. |
R834515 (2013) R834515 (2014) R834515 (2015) R834515 (Final) R834515C001 (2014) R834515C002 (2014) R834515C003 (2014) R834515C003 (2016) |
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Journal Article | An evolutionarily conserved innate immunity protein interaction network. | JOURNAL OF BIOLOGICAL CHEMISTRY | De Arras L, Seng A, Lackford B, Keikhaee MR, Bowerman B, Freedman JH, Schwartz DA, Alper S | De Arras L, Seng A, Lackford B, Keikhaee MR, Bowerman B, Freedman JH, Schwartz DA, Alper S. An evolutionarily conserved innate immunity protein interaction network. Journal of Biological Chemistry 2013;288(3):1967-1978. |
R834515 (2013) R834515 (2014) R834515 (2015) R834515 (Final) R834515C001 (2014) R834515C002 (2014) R834515C003 (2014) R834515C003 (2016) |
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Journal Article | Transcriptome profiling of the newborn mouse lung response to acute ozone exposure. | TOXICOLOGICAL SCIENCES | Gabehart K, Correll KA, Yang J, Collins ML, Loader JE, Leach S, White CW, Dakhama A | Gabehart K, Correll KA, Yang J, Collins ML, Loader JE, Leach S, White CW, Dakhama A. Transcriptome profiling of the newborn mouse lung response to acute ozone exposure. Toxicological Sciences 2014;138(1):175-190. |
R834515 (2011) R834515 (2013) R834515 (2014) R834515 (2015) R834515 (Final) R834515C001 (2014) R834515C002 (2014) R834515C002 (2015) R834515C003 (2014) |
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Journal Article | The lung response to ozone is determined by age and is partially dependent on toll-like receptor 4. | RESPIRATORY RESEARCH | Gabehart K, Correll KA, Loader JE, White CW, Dakhama A | Gabehart K, Correll KA, Loader JE, White CW, Dakhama A. The lung response to ozone is determined by age and is partially dependent on toll-like receptor 4. Respiratory Research 2015;16:117. |
R834515 (2013) R834515 (2014) R834515 (2015) R834515 (Final) R834515C001 (2014) R834515C002 (2014) R834515C002 (2015) R834515C003 (2014) |
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Journal Article | NOS3 polymorphism, lung function, and exposure in swine operations: results of 2 studies. | None | Gao Z, Dosman JA, Rennie DC, Schwartz DA, Yang IV, Beach J, Senthilselvan A | Gao Z, Dosman JA, Rennie DC, Schwartz DA, Yang IV, Beach J, Senthilselvan A. NOS3 polymorphism, lung function, and exposure in swine operations: results of 2 studies. Journal of Allergy and Clinical Immunology 2014;134(2):485-488. |
R834515 (2013) R834515 (2014) R834515 (2015) R834515 (Final) R834515C001 (2014) R834515C002 (2014) R834515C003 (2014) R834515C003 (2016) |
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Journal Article | Polymorphisms in the SUFU gene are associated with organ injury protection and sepsis severity in patients with Enterobacteriacea bacteremia. | None | Henao-Martinez AF, Agler AH, LaFlamme D, Schwartz DA, Yang IV | Henao-Martinez AF, Agler AH, LaFlamme D, Schwartz DA, Yang IV. Polymorphisms in the SUFU gene are associated with organ injury protection and sepsis severity in patients with Enterobacteriacea bacteremia. Infection, Genetics and Evolution 2013;16:386-391. |
R834515 (2013) R834515 (2014) R834515 (2015) R834515 (Final) R834515C001 (2014) R834515C002 (2014) R834515C003 (2014) R834515C003 (2016) |
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Journal Article | Role of macrophage receptor with collagenous structure in innate immune tolerance. | None | Jing J, Yang IV, Hui L, Patel JA, Evans CM, Prikeris R, Kobzik L, O'Connor BP, Schwartz DA | Jing J, Yang IV, Hui L, Patel JA, Evans CM, Prikeris R, Kobzik L, O'Connor BP, Schwartz DA. Role of macrophage receptor with collagenous structure in innate immune tolerance. Journal of Immunology 2013;190(12):6360-6367. |
R834515 (2013) R834515 (2014) R834515 (2015) R834515 (Final) R834515C001 (2014) R834515C002 (2014) R834515C003 (2014) R834515C003 (2016) |
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Journal Article | Strain-dependent genomic factors affect allergen-induced airway hyperresponsiveness in mice. | AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | Kelada SN, Wilson MS, Tavarez U, Kubalanza K, Borate B, Whitehead GS, Maruoka S, Roy MG, Olive M, Carpenter DE, Brass DM, Wynn TA, Cook DN, Evans CM, Schwartz DA, Collins FS | Kelada SN, Wilson MS, Tavarez U, Kubalanza K, Borate B, Whitehead GS, Maruoka S, Roy MG, Olive M, Carpenter DE, Brass DM, Wynn TA, Cook DN, Evans CM, Schwartz DA, Collins FS. Strain-dependent genomic factors affect allergen-induced airway hyperresponsiveness in mice. American Journal of Respiratory Cell and Molecular Biology 2011;45(4):817-824. |
R834515 (2013) R834515 (2014) R834515 (2015) R834515 (Final) R834515C001 (2014) R834515C003 (2014) R834515C003 (2016) |
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Journal Article | Integrating murine gene expression studies to understand obstructive lung disease due to chronic inhaled endotoxin. | None | Lai PS, Hofmann O, Baron RM, Cernadas M, Meng QR, Bresler HS, Brass DM, Yang IV, Schwartz DA, Christiani DC, Hide W | Lai PS, Hofmann O, Baron RM, Cernadas M, Meng QR, Bresler HS, Brass DM, Yang IV, Schwartz DA, Christiani DC, Hide W. Integrating murine gene expression studies to understand obstructive lung disease due to chronic inhaled endotoxin. PLoS One 2013;8(5):e62910. |
R834515 (2013) R834515 (2014) R834515 (2015) R834515 (Final) R834515C001 (2014) R834515C002 (2014) R834515C003 (2014) R834515C003 (2016) |
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Journal Article | The Toll-like receptor 4 polymorphism Asp299Gly but not Thr399Ile influences TLR4 signaling and function. | None | Long H, O'Connor BP, Zemans RL, Zhou X, Yang IV, Schwartz DA | Long H, O'Connor BP, Zemans RL, Zhou X, Yang IV, Schwartz DA. The Toll-like receptor 4 polymorphism Asp299Gly but not Thr399Ile influences TLR4 signaling and function. PLoS One 2014;9(4):e93550 (10 pp.). |
R834515 (2013) R834515 (2014) R834515 (2015) R834515 (Final) R834515C001 (2014) R834515C002 (2014) R834515C003 (2014) R834515C003 (2016) |
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Journal Article | Indoor pollutant exposures modify the effect of airborne endotoxin on asthma in urban children. | None | Matsui EC, Hansel NN, Aloe C, Schiltz AM, Peng RD, Rabinovitch N, Ong MJ, Williams DL, Breysse PN, Diette GB, Liu AH | Matsui EC, Hansel NN, Aloe C, Schiltz AM, Peng RD, Rabinovitch N, Ong MJ, Williams DL, Breysse PN, Diette GB, Liu AH. Indoor pollutant exposures modify the effect of airborne endotoxin on asthma in urban children. American Journal of Respiratory and Critical Care Medicine 2013;188(10):1210-1215. |
R834510 (2014) R834515 (2012) R834515 (2013) R834515 (2014) R834515 (2015) R834515 (Final) R834515C001 (2014) R834515C001 (2015) R834515C002 (2014) R834515C003 (2014) |
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Journal Article | Ozone enhances pulmonary innate immune response to a Toll-like receptor-2 agonist. | AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | Oakes JL, O'Connor BP, Warg LA, Burton R, Hock A, Loader J, LaFlamme D, Jing J, Hui L, Schwartz DA, Yang IV | Oakes JL, O'Connor BP, Warg LA, Burton R, Hock A, Loader J, LaFlamme D, Jing J, Hui L, Schwartz DA, Yang IV. Ozone enhances pulmonary innate immune response to a Toll-like receptor-2 agonist. American Journal of Respiratory Cell and Molecular Biology 2013;48(1):27-34. |
R834515 (2013) R834515 (2014) R834515 (2015) R834515 (Final) R834515C001 (2014) R834515C002 (2014) R834515C003 (2014) R834515C003 (2016) |
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Journal Article | The role of the E2F1 transcription factor in the innate immune response to systemic LPS. | AMERICAN JOURNAL OF PHYSIOLOGY - LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | Warg LA, Oakes JL, Burton R, Neidermyer AJ, Rutledge HR, Groshong S, Schwartz DA, Yang IV | Warg LA, Oakes JL, Burton R, Neidermyer AJ, Rutledge HR, Groshong S, Schwartz DA, Yang IV. The role of the E2F1 transcription factor in the innate immune response to systemic LPS. American Journal of Physiology-Lung Cellular and Molecular Physiology 2012;303(5):L391-L400. |
R834515 (2013) R834515 (2014) R834515 (2015) R834515C001 (2014) R834515C002 (2014) R834515C003 (2014) R834515C003 (2016) |
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Journal Article | Novel regulators of the systemic response to lipopolysaccharide. | AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | Yang IV, Alper S, Lackford B, Rutledge H, Warg LA, Burch LH, Schwartz DA | Yang IV, Alper S, Lackford B, Rutledge H, Warg LA, Burch LH, Schwartz DA. Novel regulators of the systemic response to lipopolysaccharide. American Journal of Respiratory Cell and Molecular Biology 2011;45(2):393-402. |
R834515 (2013) R834515 (2014) R834515 (2015) R834515 (Final) R834515C001 (2014) R834515C002 (2014) R834515C003 (2014) R834515C003 (2016) |
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Presentation | Genome-wide, pathway level gene by environment interactions in models of endotoxin exposure and asthma severity. | None | Sordillo JE, Raby BA, Liu AH, Weiss ST, Gold DR, Litonjua AA | Sordillo JE, Raby BA, Liu AH, Weiss ST, Gold DR, Litonjua AA. Genome-wide, pathway-level gene by environment interactions in models of endotoxin exposure and asthma severity. Presented at the American Thoracic Society 2014 International Conference, San Diego, CA, May 16-21, 2014. |
R834515 (2013) R834515 (2015) R834515C001 (2014) R834515C001 (2015) R834515C002 (2014) R834515C003 (2014) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.