Grantee Research Project Results
Publications Details for Grant Number R827352C002
Pro-inflammatory and the Pro-oxidative Effects of Diesel Exhaust Particulate in Vivo and in Vitro
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| Reference Type | Citation | Progress Report Year | Document Sources |
|---|---|---|---|
| Journal Article | Chan RC-F, Wang M, Li N, Yanagawa Y, Onoe K, Lee JJ, Nel AE. Pro-oxidative diesel exhaust particle chemicals inhibit LPS-induced dendritic cell responses involved in T-helper differentiation. Journal of Allergy and Clinical Immunology 2006;118(2):455-465. |
R827352 (Final) R827352C002 (Final) R832413 (2008) R832413C002 (2007) R832413C002 (2008) R832413C002 (Final) |
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| Journal Article | Hao M, Comier S, Wang M, Lee JJ, Nel A. Diesel exhaust particles exert acute effects on airway inflammation and function in murine allergen provocation models. Journal of Allergy and Clinical Immunology 2003;112(5):905-914. |
R827352 (2004) R827352 (Final) R827352C002 (Final) |
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| Journal Article | Hiura TS, Li N, Kaplan R, Horwitz M, Seagrave J-C, Nel AE. The role of a mitochondrial pathway in the induction of apoptosis by chemicals extracted from diesel exhaust particles. Journal of Immunology 2000;165(5):2703-2711. |
R827352 (2004) R827352 (Final) R827352C002 (Final) |
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| Journal Article | Li N, Venkatesan MI, Miguel A, Kaplan R, Gujuluva C, Alam J, Nel A. Induction of heme oxygenase-1 expression in macrophages by diesel exhaust particle chemicals and quinones via the antioxidant-responsive element. Journal of Immunology 2000;165(6):3393-3401. |
R827352 (2004) R827352 (Final) R827352C002 (Final) R827352C013 (Final) |
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| Journal Article | Li N, Kim S, Wang M, Froines J, Sioutas C, Nel A. Use of a stratified oxidative stress model to study the biological effects of ambient concentrated and diesel exhaust particulate matter. Inhalation Toxicology 2002;14(5):459-486. |
R827352 (2004) R827352 (Final) R827352C002 (Final) R827352C014 (Final) |
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| Journal Article | Li N, Sioutas C, Cho A, Schmitz D, Misra C, Sempf J, Wang M, Oberley T, Froines J, Nel A. Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environmental Health Perspectives 2003;111(4):455-460. |
R827352 (2004) R827352 (Final) R827352C001 (Final) R827352C002 (Final) R827352C014 (Final) |
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| Journal Article | Li N, Hao M, Phalen RF, Hinds WC, Nel AE. Particulate air pollutants and asthma: a paradigm for the role of oxidative stress in PM-induced adverse health effects. Clinical Immunology 2003;109(3):250-265. |
R827352 (2004) R827352 (Final) R827352C002 (Final) R827352C006 (Final) R827352C016 (Final) |
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| Journal Article | Li N, Alam J, Venkatesan MI, Eiguren-Fernandez A, Schmitz D, Di Stefano E, Slaughter N, Killeen E, Wang X, Huang A, Wang M, Miguel AH, Cho A, Sioutas C, Nel AE. Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals. Journal of Immunology 2004;173(5):3467-3481. |
R827352 (2004) R827352 (Final) R827352C001 (Final) R827352C002 (Final) R827352C013 (Final) R827352C014 (Final) |
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| Journal Article | Li N, Nel AE. Role of the Nrf2-mediated signaling pathway as a negative regulator of inflammation:implications for the impact of particulate pollutants on asthma. Antioxidants & Redox Signaling 2006;8(1-2):88-98. |
R827352 (Final) R827352C002 (Final) |
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| Journal Article | Lippmann M, Frampton M, Schwartz J, Dockery D, Schlesinger R, Koutrakis P, Froines J, Nel A, Finkelstein J, Godleski J, Kaufman J, Koenig J, Larson T, Luchtel D, Liu L-JS, Oberdorster G, Peters A, Sarnat J, Sioutas C, Suh H, Sullivan J, Utell M, Wichmann E, Zelikoff J. The U.S. Environmental Protection Agency Particulate Matter Health Effects Research Centers Program: a midcourse report of status, progress, and plans. Environmental Health Perspectives 2003;111(8):1074-1092. |
R827351 (2002) R827351 (Final) R827352 (Final) R827352C002 (Final) R827352C014 (Final) R827353 (Final) R827353C006 (Final) R827353C015 (Final) R827354 (Final) R827355 (Final) R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) |
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| Journal Article | Nel AE, Diaz-Sanchez D, Li N. The role of particulate pollutants in pulmonary inflammation and asthma:evidence for the involvement of organic chemicals and oxidative stress. Current Opinion in Pulmonary Medicine 2001;7(1):20-26. |
R827352 (2004) R827352 (Final) R827352C002 (Final) |
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| Journal Article | Nel AE. Air pollution-related illness: effects of particles. Science 2005;308(5723):804-806. |
R827352 (Final) R827352C002 (Final) |
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| Journal Article | Whitekus MJ, Li N, Zhang M, Wang M, Horwitz MA, Nelson SK, Horwitz LD, Brechun N, Diaz-Sanchez D, Nel AE. Thiol antioxidants inhibit the adjuvant effects of aerosolized diesel exhaust particles in a murine model for ovalbumin sensitization. Journal of Immunology 2002;168(5):2560-2567. |
R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C001 (Final) R826708C002 (Final) R827352 (Final) R827352C002 (Final) |
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| Journal Article | Xia T, Korge P, Weiss JN, Li N, Venkatesan MI, Sioutas C, Nel A. Quinones and aromatic chemical compounds in particulate matter induce mitochondrial dysfunction: implications for ultrafine particle toxicity. Environmental Health Perspectives 2004;112(14):1347-1358. |
R827352 (Final) R827352C002 (Final) R827352C014 (Final) |
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| Journal Article | Xia T, Kovochich M, Brant J, Hotze M, Sempf J, Oberley T, Sioutas C, Yeh JI, Wiesner MR, Nel AE. Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. Nano Letters 2006;6(8):1794-1807. |
R827352 (Final) R827352C002 (Final) R827352C014 (Final) R832413 (2008) R832413 (2009) R832413 (Final) R832413C001 (2007) R832413C001 (2008) R832413C001 (Final) R832413C002 (2006) R832413C002 (2008) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.