Grantee Research Project Results
Publications Details for Grant Number R832417C003
Biological Assessment of the Toxicity of PM and PM Components
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| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
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| Abstract | Particulate matter triggers ventricular arrhythmias via carotid body/autonomic dysfunction in a murine model of cardiomyopathy. | None | Lang G, Goonewardena SN, Wang T, Moreno-Vinasco L, Huang Y, Svensson EC, Natarajan V, Breysse P, Geyh A, Samet JM, Peng YJ, Lussier Y, Prabakhar N, Garcia JG | Lang G, Goonewardena SN, Wang T, Moreno-Vinasco L, Huang Y, Svensson EC, Natarajan V, Breysse P, Geyh A, Samet JM, Peng YJ, Lussier Y, Prabakhar N, Garcia JG. Particulate matter triggers ventricular arrhythmias via carotid body/autonomic dysfunction in a murine model of cardiomyopathy. Journal of Investigative Medicine 2009;57(3):546. |
R832417 (Final) R832417C003 (2009) R832417C003 (Final) |
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| Abstract | Particulate matter triggers ventricular arrhythmias and gene dysregulation in a murine model of cardiomyopathy. | None | Moreno-Vinasco L, Lang G, Wang T, Goonewardena S, Huang Y, Svensson E, Natarajan V, Breysse P, Geyh A, Peng F, Samet J, Lussier Y, Prabakhar N, Garcia JGN | Moreno-Vinasco L, Lang G, Wang T, Goonewardena S, Huang Y, Svensson E, Natarajan V, Breysse P, Geyh A, Peng F, Samet J, Lussier Y, Prabakhar N, Garcia JGN. Particulate matter triggers ventricular arrhythmias and gene dysregulation in a murine model of cardiomyopathy. American Journal of Respiratory and Critical Care Medicine 2009;179:A3144. |
R832417 (Final) R832417C003 (2009) R832417C003 (Final) |
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| Abstract | Particulate matter (PM)-mediated human lung endothelial cell barrier dysfunction involves oxidative stress, MLCK activation, and tight junction protein degradation. | None | Wang T, Wang, L, Moreno-Vinasco L, Samet JM, Geyh AS, Breysse PN, Natarajan V, Garcia JGN | Wang T, Wang, L, Moreno-Vinasco L, Samet JM, Geyh AS, Breysse PN, Natarajan V, Garcia JGN. Particulate matter (PM)-mediated human lung endothelial cell barrier dysfunction involves oxidative stress, MLCK activation, and tight junction protein degradation. American Journal of Respiratory and Critical Care Medicine 2009;179:A3169. |
R832417 (Final) R832417C003 (2009) R832417C003 (Final) |
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| Abstract | Particulate matter (PM)-mediated human lung endothelial cell barrier dysfunction involves oxidative stress, MLCK activation, and tight junction protein degradation. | None | Wang T, Wang, L, Moreno-Vinasco L, Samet JM, Geyh AS, Breysse PN, Natarajan V, Garcia JGN | Wang T, Wang, L, Moreno-Vinasco L, Samet JM, Geyh AS, Breysse PN, Natarajan V, Garcia JGN. Particulate matter (PM)-mediated human lung endothelial cell barrier dysfunction involves oxidative stress, MLCK activation, and tight junction protein degradation. Journal of Investigative Medicine 2009;57(3):552. |
R832417 (Final) R832417C003 (Final) |
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| Journal Article | Murine lung responses to ambient particulate matter: genomic analysis and influence on airway hyperresponsiveness. | None | Wang T, Moreno-Vinasco L, Huang Y, Lang GD, Linares JD, Goonewarena SN, Grabavoy A, Samet JM, Geyh AS, Breysse PN, Lussier YA, Natarajan V, Garcia JGN | Wang T, Moreno-Vinasco L, Huang Y, Lang GD, Linares JD, Goonewardena SN, Grabavoy A, Samet JM, Geyh AS, Breysse PN, Lussier YA, Natarajan V, Garcia JGN. Murine lung responses to ambient particulate matter: genomic analysis and influence on airway hyperresponsiveness. Environmental Health Perspectives 2008;116(11):1500-1508. |
R832417 (2008) R832417 (Final) R832417C003 (2008) R832417C003 (2009) |
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| Journal Article | Particulate matter disrupts human lung endothelial barrier integrity via ROS- and p38 MAPK-dependent pathways. | AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | Wang T, Chiang ET, Moreno-Vinasco L, Lang GD, Pendyala S, Samet JM, Geyh AS, Breysse PN, Chillrud SN, Natarajan V, Garcia JGN | Wang T, Chiang ET, Moreno-Vinasco L, Lang GD, Pendyala S, Samet JM, Geyh AS, Breysse PN, Chillrud SN, Natarajan V, Garcia JGN. Particulate matter disrupts human lung endothelial barrier integrity via ROS-and p38 MAPK-dependent pathways. American Journal of Respiratory Cell and Molecular Biology 2010;42(4):442-449. |
R832417 (Final) R832417C003 (2009) |
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| Journal Article | Hydrogen sulfide attenuates particulate matter-induced human lung endothelial barrier disruption via combined ROS scavenging and Akt activation. | AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | Wang T, Wang L, Zaidi SR, Sammani S, Siegler J, Moreno-Vinasco L, Mathew B, Natarajan V, Garcia JG | Wang T, Wang L, Zaidi SR, Sammani S, Siegler J, Moreno-Vinasco L, Mathew B, Natarajan V, Garcia JG. Hydrogen sulfide attenuates particulate matter-induced human lung endothelial barrier disruption via combined reactive oxygen species scavenging and Akt activation. American Journal of Respiratory Cell and Molecular Biology 2012;47(4):491-496. |
R832417 (Final) R832417C003 (Final) |
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| Journal Article | Regulation of COX-2 expression and IL-6 release by particulate matter in airway epithelial cells. | None | Zhao Y, Usatyuk PV, Gorshkova IA, He D, Wang T, Moreno-Vinasco L, Geyh AS, Breysse PN, Samet JM, Spannhake EW, Garcia JGN, Natarajan V | Zhao Y, Usatyuk PV, Gorshkova IA, He D, Wang T, Moreno-Vinasco L, Geyh AS, Breysse PN, Samet JM, Spannhake EW, Garcia JGN, Natarajan V. Regulation of COX-2 expression and IL-6 release by particulate matter in airway epithelial cells. American Journal of Respiratory Cell and Molecular Biology 2009;40(1):19-30. |
R832417 (2008) R832417 (Final) R832417C003 (2008) R832417C003 (2009) |
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| Presentation | Biological effect of PM exposure in a susceptible murine strain. | None | Moreno L, Grabavoy A, Goonewardena S, Sammani S, Natarajan V, Breysee P, Geyh A, Samet JM, Garcia JGN | Moreno L, Grabavoy A, Goonewardena S, Sammani S, Natarajan V, Breysee P, Geyh A, Samet JM, Garcia JGN. Biological effect of PM exposure in a susceptible murine strain. Presented at The Role of Air Pollutants in Cardiovascular Disease, EPA Science To Achieve Results (STAR) Progress Review Workshop, Research Triangle Park, NC, October 12-13, 2006. |
R832417C001 (2008) R832417C003 (2007) R832417C003 (2008) |
not available |
| Presentation | Particulate matter exacerbates respiratory and cardiac arrhythmias in cardiomyopathic mice via heightened carotid body sensitivity. | None | Moreno-Vinasco L, Lang G, Wang T, Huang T, Goonewardena S, Svensson E, Natarajan V, Breysse P, Samet J, Peng Y, Lussier Y, Prabakhar N, Garcia JGN | Moreno-Vinasco L, Lang G, Wang T, Huang T, Goonewardena S, Svensson E, Natarajan V, Breysse P, Samet J, Peng Y, Lussier Y, Prabakhar N, Garcia JGN. Particulate matter exacerbates respiratory and cardiac arrhythmias in cardiomyopathic mice via heightened carotid body sensitivity. Presented at the American Association for Aerosol Research (AAAR) 2010 Specialty Conference, San Diego, CA, March 22-26, 2010. |
R832417 (Final) R832417C003 (Final) |
not available |
| Presentation | Airway asthmatic inflammation and asthma gene dysregulation by airborne particulate matter in phoenix AZ and Sacramento CA: a comparison study. | None | Wang T, Moreno-Vinasco L, Joson L, Lang GD, Samet JM, Rule AM, Ramos-Bonilla JP, Mihalic JN, Polyak L, Geyh AS, Breysse PN, Natarajan V, Garcia JGN | Wang T, Moreno-Vinasco L, Joson L, Lang GD, Samet JM, Rule AM, Ramos-Bonilla JP, Mihalic JN, Polyak L, Geyh AS, Breysse PN, Natarajan V, Garcia JGN. Airway asthmatic inflammation and asthma gene dysregulation by airborne particulate matter in phoenix AZ and Sacramento CA:a comparison study. Poster presented at the American Association for Aerosol Research (AAAR) 2010 Specialty Conference, San Diego, CA, March 22-26, 2010. |
R832417 (Final) R832417C003 (Final) |
not available |
| Presentation | The protective role of hydrogen sulfide in attenuating particulate matter-induced endothelial barrier disruption. | None | Wang T, Moreno-Vinasco L, Lang GD, Zaidi SR, Wang L, Natarajan V, Garcia JGN | Wang T, Moreno-Vinasco L, Lang GD, Zaidi SR, Wang L, Natarajan V, Garcia JGN. The protective role of hydrogen sulfide in attenuating particulate matter-induced endothelial barrier disruption. Poster presented at the American Association for Aerosol Research (AAAR) 2010 Specialty Conference, San Diego, CA, March 22-26, 2010. |
R832417 (Final) R832417C003 (Final) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.