Grantee Research Project Results
2008 Progress Report: Estimation of the Risks to Human Health of PM and PM Components
EPA Grant Number: R832417C001Subproject: this is subproject number 001 , established and managed by the Center Director under grant R832417
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Center for the Study of Childhood Asthma in the Urban Environment
Center Director: Hansel, Nadia
Title: Estimation of the Risks to Human Health of PM and PM Components
Investigators: Dominici, Francesca , Peng, Roger D. , Bell, Michelle L. , Zeger, Scott L. , Samet, Jonathan M.
Current Investigators: Peng, Roger D. , Bell, Michelle L. , Samet, Jonathan M. , Dominici, Francesca
Institution: The Johns Hopkins University , Yale University
EPA Project Officer: Chung, Serena
Project Period: October 1, 2005 through September 30, 2010
Project Period Covered by this Report: October 1, 2007 through September 30,2008
RFA: Particulate Matter Research Centers (2004) RFA Text | Recipients Lists
Research Category: Human Health , Air
Objective:
Approach:
In ongoing studies of air pollution and health the National Medicare Cohort, comprising individual-level data on diseases, age, gender, and race for virtually the entire population of US elderly, is limited by geographical location to: 1) air pollution concentrations of gaseous pollutants, PM10, PM2.5, and PM2.5 components; 2) weather; 3) socio-economic data; and 4) smoking and other risk factors for 13,000 Medicare enrollees. In this project, we will develop and apply statistical methods to these national databases to: 1) carry out multi-site time series studies for estimating short-term effects of PM and PM components on hospitalization and mortality (Phase I); 2) carry out cohort-studies for estimating long-term effects of PM and PM components on mortality in susceptible populations (Phase II); and 3) assess coherence of evidence from bioassays and epidemiological studies on PM toxicity and susceptibility; and explore linkages of sources of harmful PM components to human health risks (Phase III).
Progress Summary:
Expected Results:
This project will address the following objectives of the Center on a national scale: 1) mapping risks of PM and PM constituents to human health across the United States; 2) using the maps to identify a sampling frame of locations with contrasting higher and lower risks; 3) carrying out more refined epidemiological studies to estimate further the risks of the more toxic particles to susceptible individuals. By providing individual-level health data for the entire US population of elderly, the National Medicare Cohort will allow us to take full advantage of existing and future air quality databases on PM and its characteristics.
Journal Articles on this Report : 16 Displayed | Download in RIS Format
Other subproject views: | All 41 publications | 36 publications in selected types | All 34 journal articles |
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Other center views: | All 89 publications | 66 publications in selected types | All 64 journal articles |
Type | Citation | ||
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Bell ML, Dominici F, Ebisu K, Zeger SL, Samet JM. Spatial and temporal variation in PM2.5 chemical composition in the United States for health effects studies. Environmental Health Perspectives 2007;115(7):989-995. |
R832417 (Final) R832417C001 (2006) R832417C001 (2007) R832417C001 (2008) R832417C001 (2009) R832417C001 (Final) R830548 (Final) |
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Bell ML, Kim JY, Dominici F. Potential confounding of particulate matter on the short-term association between ozone and mortality in multisite time-series studies. Environmental Health Perspectives 2007;115(11):1591-1595. |
R832417 (Final) R832417C001 (2007) R832417C001 (2008) R832417C001 (2009) R832417C001 (Final) R830548 (Final) |
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Crainiceanu CM, Dominici F, Parmigiani G. Adjustment uncertainty in effect estimation. Biometrika 2008;95(3):635-651. |
R832417 (Final) R832417C001 (2008) R832417C001 (2009) R832417C001 (Final) |
Exit |
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Dominici F, Peng RD, Bell ML, Pham L, McDermott A, Zeger SL, Samet JM. Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases. JAMA-Journal of the American Medical Association 2006;295(10):1127-1134. |
R832417 (Final) R832417C001 (2006) R832417C001 (2007) R832417C001 (2008) R832417C001 (2009) R832417C001 (Final) R830548 (2005) |
Exit Exit |
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Dominici F, Peng RD, Ebisu K, Zeger SL, Samet JM, Bell ML. Does the effect of PM10 on mortality depend on PM nickel and vanadium content? A reanalysis of the NMMAPS data. Environmental Health Perspectives 2007;115(12):1701-1703. |
R832417 (Final) R832417C001 (2008) R832417C001 (2009) R832417C001 (Final) R830548 (Final) |
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Dominici F, Peng RD, Zeger SL, White RH, Samet JM. Dominici et al. respond to "Heterogeneity of particulate matter health risks." American Journal of Epidemiology 2007;166(8):892-893. |
R832417 (2008) R832417 (Final) R832417C001 (2008) R832417C001 (2009) R832417C001 (Final) |
Exit Exit |
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Dominici F, Peng RD, Zeger SL, White RH, Samet JM. Particulate air pollution and mortality in the United States: did the risks change from 1987 to 2000? American Journal of Epidemiology 2007;166(8):880-888. |
R832417 (Final) R832417C001 (2007) R832417C001 (2008) R832417C001 (2009) R832417C001 (Final) R830548 (Final) R833622 (2008) R833622 (2009) |
Exit Exit Exit |
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Dominici F, Wang C, Crainiceanu C, Parmigiani G. Model selection and health effect estimation in environmental epidemiology. Epidemiology 2008;19(4):558-560. |
R832417 (2008) R832417 (Final) R832417C001 (2008) R832417C001 (2009) R832417C001 (Final) |
Exit Exit Exit |
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Eftim SE, Samet JM, Janes H, McDermott A, Dominici F. Fine particulate matter and mortality: a comparison of the six cities and American Cancer Society cohorts with a Medicare cohort. Epidemiology 2008;19(2):209-216. |
R832417 (2008) R832417 (Final) R832417C001 (2008) R832417C001 (2009) R832417C001 (Final) R833622 (2008) R833622 (2009) |
Exit Exit Exit |
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Janes H, Dominici F, Zeger S. Partitioning evidence of association between air pollution and mortality. Epidemiology 2007;18(4):427-428. |
R832417 (2008) R832417 (Final) R832417C001 (2008) R832417C001 (2009) R832417C001 (Final) R833622 (2008) R833622 (2009) R833622 (Final) |
Exit Exit Exit |
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Janes H, Dominici F, Zeger SL. Trends in air pollution and mortality: an approach to the assessment of unmeasured confounding. Epidemiology 2007;18(4):416-423. |
R832417 (Final) R832417C001 (2006) R832417C001 (2007) R832417C001 (2008) R832417C001 (2009) R832417C001 (Final) R830548 (Final) R833622 (Final) |
Exit Exit Exit |
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Peng RD, Dominici F, Louis TA. Model choice in time series studies of air pollution and mortality. Journal of the Royal Statistical Society Series A-Statistics in Society 2006;169(2):179-203. |
R832417 (Final) R832417C001 (2006) R832417C001 (2007) R832417C001 (2008) R830548 (Final) |
Exit Exit Exit |
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Peng RD, Dominici F, Zeger SL. Reproducible epidemiological research. American Journal of Epidemiology 2006;163(9):783-789. |
R832417 (Final) R832417C001 (2006) R832417C001 (2007) R832417C001 (2008) R832417C001 (2009) R832417C001 (Final) R830548 (Final) |
Exit Exit Exit |
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Peng RD, Chang HH, Bell ML, McDermott A, Zeger SL, Samet JM, Dominici F. Coarse particulate matter air pollution and hospital admissions for cardiovascular and respiratory diseases among Medicare patients. JAMA-Journal of the American Medical Association 2008;299(18):2172-2179. |
R832417 (2008) R832417 (Final) R832417C001 (2008) R832417C001 (2009) R832417C001 (Final) R833622 (2008) R833622 (2009) R833622 (Final) |
Exit Exit Exit |
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Symons JM, Wang L, Guallar E, Howell E, Dominici F, Schwab M, Ange BA, Samet J, Ondov J, Harrison D, Geyh A. A case-crossover study of fine particulate matter air pollution and onset of congestive heart failure symptom exacerbation leading to hospitalization. American Journal of Epidemiology 2006;164(5):421-433. |
R832417 (Final) R832417C001 (2006) R832417C001 (2007) R832417C001 (2008) R832417C001 (2009) R832417C001 (Final) R830548 (Final) |
Exit Exit Exit |
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Thomas DC, Jerrett M, Kuenzli N, Louis TA, Dominici F, Zeger S, Schwartz J, Burnett RT, Krewski D, Bates D. Bayesian model averaging in time-series studies of air pollution and mortality. Journal of Toxicology and Environmental Health-Part A 2007;70(3-4):311-315. |
R832417 (Final) R832417C001 (2007) R832417C001 (2008) R832417C001 (2009) R832417C001 (Final) R830548 (Final) R831861 (2005) |
Exit |
Supplemental Keywords:
time series, susceptible populations, risk estimates, RFA, Health, PHYSICAL ASPECTS, Scientific Discipline, Air, particulate matter, Health Risk Assessment, Epidemiology, Risk Assessments, Physical Processes, atmospheric particulate matter, acute cardiovascular effects, long term exposure, atmospheric particles, airway disease, exposure, ambient particle health effects, human exposure, ultrafine particulate matter, atmospheric aerosol particles, aersol particles, cardiovascular diseaseRelevant Websites:
www.jhsph.edu/particulate_matterProgress and Final Reports:
Original AbstractMain Center Abstract and Reports:
R832417 Center for the Study of Childhood Asthma in the Urban Environment Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R832417C001 Estimation of the Risks to Human Health of PM and PM Components
R832417C002 PM Characterization and Exposure Assessment (Project 2)
R832417C003 Biological Assessment of the Toxicity of PM and PM Components
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
34 journal articles for this subproject
Main Center: R832417
89 publications for this center
64 journal articles for this center