Contact Us

Grantee Research Project Results

Other Views

Abstract (10)
Book Chapter (1)
Journal Article (5)
Paper (2)
Presentation (13)
Reference Type Reference Title Journal Author Citation Progress Report Year Document Sources
Abstract Effect of tissue binding uncertainty on a PBTK model of methylmercury in the fetal rat None Lewandowski TA, Bartell SM, Pierce CH, Ponce RA, Faustman EM Lewandowski TA, Bartell SM, Pierce CH, Ponce RA, Faustman EM. Effect of tissue binding uncertainty on a PBTK model of methylmercury in the fetal rat. Toxicology Letters 1998;95(Suppl 1):130. R825358 (Final)
Abstract Toxicokinetic and toxicodynamic modeling of the effects of methylmercury on the fetal rat None Lewandowski TA, Bartell SM, Pierce CH, Ponce RA, Faustman EM Lewandowski TA, Bartell SM, Pierce CH, Ponce RA, Faustman EM. Toxicokinetic and toxicodynamic modeling of the effects of methylmercury on the fetal rat. The Toxicologist 1998;42:139. R825173 (1999)
R825358 (Final)
 not available
Abstract Biologically-based dose-response model for methylmercury developmental toxicity incorporating novel in vivo cell cycling data None Lewandowski TA, Ponce RA, Hong S, Bartell SM, Faustman EM Lewandowski TA, Ponce RA, Hong S, Bartell SM, Faustman EM. Biologically-based dose-response model for methylmercury developmental toxicity incorporating novel in vivo cell cycling data. The Toxicologist 2000;54:1370. R825358 (Final)
 not available
Abstract In vivo determination of cell cycling rates in embryonic rat neural cells: development of a biologically-based toxicodynamic model for methylmercury risk assessment None Lewandowski TA, Schroeder JL, Ponce RA, Bartell SM, Faustman EM Lewandowski TA, Schroeder JL, Ponce RA, Bartell SM, Faustman EM. In vivo determination of cell cycling rates in embryonic rat neural cells:development of a biologically-based toxicodynamic model for methylmercury risk assessment. The Toxicologist 1999. R825358 (Final)
 not available
Abstract Methylmercury's effects on mitochondrial DNA in developing rodent midbrain. THE TOXICOLOGIST Lu S, Kavanagh TJ, Faustman EM Lu S, Kavanagh TJ, Faustman EM. Methylmercury's effects on mitochondrial DNA in developing rodent midbrain. The Toxicologist 2000;54:162. R825358 (Final)
 not available
Abstract Cell cycle phase-specific expression of cell cycle regulatory genes in rodent embryonic neuroepithelial cells exposed to methylmercury None McMillan MJ, Ponce RA, Kirchner SC, Hunt KA, Hong S, Ou YC, Faustman EM McMillan MJ, Ponce RA, Kirchner SC, Hunt KA, Hong S, Ou YC, Faustman EM. Cell cycle phase-specific expression of cell cycle regulatory genes in rodent embryonic neuroepithelial cells exposed to methylmercury. Teratology 1998;57:225. R825358 (Final)
 not available
Abstract Involvement of p21WAF1/CIP1 in methlymercury induced cell cycle inhibition None Mendoza MA, Ponce RA, Ou YC, Faustman EM Mendoza MA, Ponce RA, Ou YC, Faustman EM. Involvement of p21WAF1/CIP1 in methlymercury induced cell cycle inhibition. The Toxicologist 2000;54:238. R825358 (Final)
 not available
Abstract A p53 independent methyl mercury-induced G2/M arrest None Mendoza MAC, Ou YC, Hong S, Faustman EM Mendoza MAC, Ou YC, Hong S, Faustman EM. A p53 independent methyl mercury-induced G2/M arrest. The Toxicologist 1999;48:282. R825358 (Final)
 not available
Abstract Induction of necrotic and apoptotic cell death following methylmercyr (MeHg) exposure in primary embryonic CNS cells. THE TOXICOLOGIST Ou YC, Lu S, Faustman EM Ou YC, Lu S, Faustman EM. Induction of necrotic and apoptotic cell death following methylmercyr (MeHg) exposure in primary embryonic CNS cells. The Toxicologist 1998;42(1-S):196. R825358 (Final)
 not available
Abstract Comparative analyses of exposure estimates based on biomarkers or predictive models: a case example with dietary methylmercury intake None Ponce RA, Bartell SM, Sanga RN, Faustman EM Ponce RA, Bartell SM, Sanga RN, Faustman EM. Comparative analyses of exposure estimates based on biomarkers or predictive models: a case example with dietary methylmercury intake. Toxicology Letters 1998;95(Suppl 1):131-132. R825358 (Final)
Book Chapter In vitro models for evaluating developmental toxicity. None Lewandowski TA, Ponce RA, Whittaker SG, Faustman EM Lewandowski TA, Ponce RA, Whittaker SG, Faustman EM. In vitro models for evaluating developmental toxicity. In: Gad SC, ed. In Vitro Toxicology. New York, NY: Taylor & Francis, 2000, Chapter 8, pp. 139-185. R825358 (Final)
Journal Article Methylmercury distribution in the pregnant rat and embryo during early midbrain organogenesis. TERATOLOGY Lewandowski TA, Pierce CH, Pingree SD, Hong S, Faustman EM Lewandowski TA, Pierce CH, Pingree SD, Hong S, Faustman EM. Methylmercury distribution in the pregnant rat and embryo during early midbrain organogenesis. Teratology 2002;66(5):235-241. R825358 (Final)
R826886 (2000)
Journal Article Changes in cell cycle kinetics and cell number in the rat midbrain during organogenesis. None Lewandowski TA, Ponce RA, Charleston JS, Hong S, Faustman EM Lewandowski TA, Ponce RA, Charleston JS, Hong S, Faustman EM. Effect of methylmercury on midbrain cell proliferation during organogenesis: potential cross-species differences and implications for risk assessment. Toxicological Sciences 2003;75(1):124-133. R825358 (Final)
Journal Article p21WAF1/CIP1 inhibits cell cycle progression but not G2/M-phase transition following methylmercury exposure. TOXICOLOGY AND APPLIED PHARMACOLOGY Mendoza MAC, Ponce RA, Ou YC, Faustman EM Mendoza MAC, Ponce RA, Ou YC, Faustman EM. p21WAF1/CIP1 inhibits cell cycle progression but not G2/M-phase transition following methylmercury exposure. Toxicology and Applied Pharmacology 2002;178(2):117-125. R825358 (Final)
R826886 (2000)
Journal Article Induction of the cell cycle regulatory gene p21 (Waf1, Cip1) following methylmercury exposure in vitro and in vivo. TOXICOLOGY AND APPLIED PHARMACOLOGY Ou YC, Thompson SA, Ponce RA, Schroeder J, Kavanagh TJ, Faustman EM Ou YC, Thompson SA, Ponce RA, Schroeder J, Kavanagh TJ, Faustman EM. Induction of the cell cycle regulatory gene p21 (Waf1, Cip1) following methylmercury exposure in vitro and in vivo. Toxicology and Applied Pharmacology 1999;157(3):203-212. R825358 (Final)
R826886 (2000)
Journal Article The role of intracellular glutathione in methylmercury-induced toxicity in embryonic neuronal cells. NEUROTOXICOLOGY Ou YC, White CC, Krejsa CM, Ponce RA, Kavanagh TJ, Faustman EM Ou YC, White CC, Krejsa CM, Ponce RA, Kavanagh TJ, Faustman EM. The role of intracellular glutathione in methylmercury-induced toxicity in embryonic neuronal cells. NeuroToxicology 1999;20(5):793-804. R825358 (Final)
R826886 (2000)
Paper Linking mechanism-based toxicokinetic and toxicodynamic models for neurodevelopmental toxicity. None Lewandowski TA, Bartell SM, Ponce RA, Faustman EM Lewandowski TA, Bartell SM, Ponce RA, Faustman EM. Linking mechanism-based toxicokinetic and toxicodynamic models for neurodevelopmental toxicity. R825358 (Final)
 not available
Paper Use of physiological and toxicological data in a biologically-based model of methylmercury developmental toxicity. None Lewandowski TA, Bartell SM, Ponce RA, Faustman EM Lewandowski TA, Bartell SM, Ponce RA, Faustman EM. Use of physiological and toxicological data in a biologically-based model of methylmercury developmental toxicity. R825358 (Final)
 not available
Presentation Human variability in steady state blood-to-hair, blood-to-intake, and hair-to-intake ratios for mercury: implications for health risk assessment None Bartell SM, Ponce RA, Sanga RN, Faustman EM Bartell SM, Ponce RA, Sanga RN, Faustman EM. Human variability in steady state blood-to-hair, blood-to-intake, and hair-to-intake ratios for mercury: implications for health risk assessment. Presented at the Fifth International Conference on Mercury as a Global Pollutant, Rio de Janeiro, Brazil, May 23-27 1999. R825358 (Final)
 not available
Presentation Biologically-based dose-response model for methylmercury developmental toxicity incorporating novel in vivo cell cycling data None Lewandowski TA, Ponce RA, Hong S, Bartell SM, Faustman EM Lewandowski TA, Ponce RA, Hong S, Bartell SM, Faustman EM. Biologically-based dose-response model for methylmercury developmental toxicity incorporating novel in vivo cell cycling data. Presented to the Society of Toxicology, Philadelphia, PA, 2000. R825358 (Final)
 not available
Presentation Effect of tissue binding uncertainty on a PBTK model of methylmercury in the fetal rat None Lewandowski TA, Bartell SM, Pierce CH, Ponce RA, Faustman EM Lewandowski TA, Bartell SM, Pierce CH, Ponce RA, Faustman EM. Effect of tissue binding uncertainty on a PBTK model of methylmercury in the fetal rat. Presented at the International Union of Toxicology Meeting, Paris, France, 1998. R825358 (Final)
 not available
Presentation In vivo determination of cell cycling rates in embryonic rat neural cells: development of a biologically-based toxicodynamic model for methylmercury risk assessment None Lewandowski TA, Schroeder JL, Ponce RA, Bartell SM, Faustman EM Lewandowski TA, Schroeder JL, Ponce RA, Bartell SM, Faustman EM. In vivo determination of cell cycling rates in embryonic rat neural cells: development of a biologically-based toxicodynamic model for methylmercury risk assessment. Presented at the Society of Toxicology Annual Meeting, New Orleans, LA, 1999. R825358 (Final)
 not available
Presentation Methylmercury distribution in pregnant rats and their fetuses during early organogenesis None Lewandowski TA, Hong SW, Pingree S, Pierce CH, Ponce RA, Faustman EM Lewandowski TA, Hong SW, Pingree S, Pierce CH, Ponce RA, Faustman EM. Methylmercury distribution in pregnant rats and their fetuses during early organogenesis. Presented to the Teratology Society, Keystone, CO, 1999. R825358 (Final)
 not available
Presentation PBTK model of methylmercury toxicity in the fetal rat None Lewandowski TA, Bartell SM, Pierce CH, Ponce RA, Faustman EM Lewandowski TA, Bartell SM, Pierce CH, Ponce RA, Faustman EM. PBTK model of methylmercury toxicity in the fetal rat. Presented at the Society of Risk Analysis Annual Meeting, Pheonix, AZ, December 1998. R825358 (Final)
 not available
Presentation Toxicokinetic and toxicodynamic modeling of the effects of methylmercury on the fetal rat None Lewandowski TA, Bartell SM, Pierce CH, Ponce RA, Faustman EM Lewandowski TA, Bartell SM, Pierce CH, Ponce RA, Faustman EM. Toxicokinetic and toxicodynamic modeling of the effects of methylmercury on the fetal rat. Presented at the Society of Toxicology Annual Meeting, Seattle, WA, 1998. R825358 (Final)
 not available
Presentation Mechanisms of methylmercury-induced cell cycle arrest and cell death in primary embryonic cells. None Lu SJ, McMillan MJ, Kirchner SC, Ou YC, Faustman EM Lu SJ, McMillan MJ, Kirchner SC, Ou YC, Faustman EM. Mechanisms of methylmercury-induced cell cycle arrest and cell death in primary embryonic cells. Presented to the Congress of the International Union of Toxicology, Paris, France, July 1998. R825358 (Final)
 not available
Presentation Methlymercury's effects on mitochondrial DNA in developing rodent midbrain None Lu S, Kavanagh TJ, Faustman EM Lu S, Kavanagh TJ, Faustman EM. Methlymercury's effects on mitochondrial DNA in developing rodent midbrain. Presented at the Society of Toxicology Annual Meeting, Philadelphia, PA, 2000. R825358 (Final)
 not available
Presentation Cell cycle phase-specific expression of cell cycle regulatory genes in rodent embryonic neuroepithelial cells exposed to methylmercury None McMillan MJ, Ponce RA, Kirchner SC, Hunt KA, Hong S, Ou YC, Faustman EM McMillan MJ, Ponce RA, Kirchner SC, Hunt KA, Hong S, Ou YC, Faustman EM. Cell cycle phase-specific expression of cell cycle regulatory genes in rodent embryonic neuroepithelial cells exposed to methylmercury. Presented at the Teratology Society Annual Meeting, San Diego, CA, 1998. R825358 (Final)
 not available
Presentation Involvement of p21WAF1/CIP1 in methlymercury induced cell cycle inhibition None Mendoza MA, Ponce RA, Ou YC, Faustman EM Mendoza MA, Ponce RA, Ou YC, Faustman EM. Involvement of p21WAF1/CIP1 in methlymercury induced cell cycle inhibition. Presented at the Society of Toxicology Annual Meeting, Philadelphia, PA, 2000. R825358 (Final)
 not available
Presentation A p53 independent methyl mercury-induced G2/M arrest None Mendoza MAC, Ou YC, Hong S, Faustman EM Mendoza MAC, Ou YC, Hong S, Faustman EM. A p53 independent methyl mercury-induced G2/M arrest. Presented at the Society of Toxicology Annual Meeting, New Orleans, LA, 1999. R825358 (Final)
 not available
Presentation Comparative analyses of exposure estimates based on biomarkers or predictive models: a case example with dietary methylmercury intake None Ponce RA, Bartell SM, Sanga RN, Faustman EM Ponce RA, Bartell SM, Sanga RN, Faustman EM. Comparative analyses of exposure estimates based on biomarkers or predictive models: a case example with dietary methylmercury intake. Presented at the International Union of Toxicology Meeting, Paris, France, 1998. R825358 (Final)
 not available

Top of Page

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

Site Navigation

Related Information