Grantee Research Project Results
Publications Details for Grant Number R825280
Interindividual Variations in Genetic Polymorphisms as Risks for Colorectal Cancer
RFA:
Role of Interindividual Variation in Human Susceptibility to Cancer (1996)
Other Views
- All
Publications - Selected
Publication Types - Journal
Articles - Publications Submitted
After Final Report - Redisplay this page with
Reference Title, Journal, and Author Columns - Display this Page
in RIS Format
| Reference Type | Citation | Progress Report Year | Document Sources |
|---|---|---|---|
| Journal Article | Coles B, Nowell SA, MacLeod SL, Sweeney C, Lang NP, Kadlubar FF. The role of human glutathione S-transferases (hGSTs) in the detoxification of the food-derived carcinogen metabolite N-acetoxy-PhIP, and the effect of a polymorphism in hGSTA1 on colorectal cancer risk. Mutation Research 2001 482(1-2):3-10. |
R825280 (Final) |
not available |
| Journal Article | Dingley KH, Curtis KD, Nowell S, Felton JS, Lang NP, Turteltaub KW. DNA and protein adduct formation in the colon and blood of humans after exposure to a dietary-relevant dose of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Cancer Epidemiology, Biomarkers & Prevention 1999;8(6):507-512. |
R825280 (Final) |
not available |
| Journal Article | Frame LT, Ozawa S, Nowell SA, Chou H-C, DeLongchamp RR, Doerge DR, Lang NP, Kadlubar FF. A simple colorimetric assay for phenotyping the major human thermostable phenol sulfotransferase (SULT1A1) using platelet cytosols. Drug Metabolism and Disposition 2000;28(9):1063-1068. |
R825280 (Final) |
not available |
| Journal Article | Lang NP, Nowell S, Malfatti MA, Kulp KS, Knize MG, Davis C, Massengill J, Williams S, MacLeod S, Dingley KH, Felton JS, Turteltaub KW. In vivo human metabolism of [2-C-14]2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine (PhIP). Cancer Letters 1999;143(2):135-138 |
R825280 (Final) |
not available |
| Journal Article | MacLeod SL, Nowell S, Massengill J, Jazieh A, McClure G, Plaxco J, Kadlubar FF, Lang NP. Cancer therapy and polymorphisms of cytochromes P450. Clinical Chemistry and Laboratory Medicine 2000;38(9):883-887. |
R825280 (Final) |
not available |
| Journal Article | Malfatti MA, Kulp KS, Knize MG, Davis C, Massengill JP, Williams S, Nowell S, MacLeod S, Dingley KH, Turteltaub KW, Lang NP, Felton JS. The identification of [2-C-14]2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine metabolites in humans. Carcinogenesis 1999;20(4):705-713 |
R825280 (Final) |
not available |
| Journal Article | Nowell SA, Massengill JS, Williams S, Radominska-Pandya A, Tephly TR, Cheng ZQ, Strassburg CP, Tukey RH, MacLeod SL, Lang NP, Kadlubar FF. Glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine by human microsomal UDP-glucuronosyltransferases: identification of specific UGT1A family isoforms involved. Carcinogenesis 1999;20(6):1107-1114 |
R825280 (Final) |
not available |
| Journal Article | Nowell S, Ambrosone CB, MacLeod SL, Williams S, Mrackova G, Plaxco J, Ozawa S, Kadlubar FF, Lang NP. Relationship of phenol sulfotransferase (SULT1A1) genotype to sulfotransferase activity phenotype in platelet cytosol. Pharmacogenetics 2000;10:789-797. |
R825280 (Final) |
not available |
| Journal Article | Ozawa S., Tang Y.M., Yamazoe Y., Kato R., Lang N.P. and Kadlubar F.F. Genetic polymorphisms in human liver phenol sulfotransferases involved in the bioactivation of N-hydroxy derivatives of carcinogenic arylamines and heterocyclic amines. Chemico-Biological Interactions, Volume 109, Issues 1-3, 20 February 1998, Pages 237-248. |
R825280 (Final) |
not available |
| Journal Article | Turteltaub KW, Dingley KH, Curtis KD, Malfatti MA, Turesky RJ, Garner RC, Felton JS, Lang NP. Macromolecular adduct formation and metabolism of heterocyclic amines in humans and rodents at low doses. Cancer Letters 1999;143(2):149-155. |
R825280 (Final) |
not available |
| Presentation | Colon cancer from etiology to prevention. Thomas G. Orr Memorial Lectureship. American Journal of Surgery 1997;174(6):578-582. |
R825280 (Final) |
not available |
| Proceedings | Statistical methods for density estimation applied to NAT2 activities from an Arkansas population. In: Proceedings of the American Association for Cancer Research 1999;40:619. |
R825280 (Final) |
not available |
| Proceedings | Methods for the determination of carcinogens/mutagens in the diet and applications to risk assessment. In: ISSX Proceedings 1998;13:1. |
R825280 (Final) |
not available |
| Proceedings | Thermostable phenolsulfotransferase (TS-PST) phenotype as a potential risk factor for colon cancer in a case-control study. In: Proceedings of the American Association for Cancer Research 1997;38:A1449. |
R825280 (Final) |
not available |
| Proceedings | MacLeod SL, Nowell SA, Tang Y-M, Kadlubar FF, Lang NP. CYP1B1 polymorphism in colorectal cancer. In: Proceedings of the American Association for Cancer Research 2000;41. |
R825280 (Final) |
not available |
| Proceedings | The role of a recently discovered genetic polymorphism in the regulation of the human CYP1A2 gene. In: Proceedings of the American Association for Cancer Research 1998;39:396. |
R825280 (Final) |
not available |
| Proceedings | The detection of [2-14C]2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine metabolites in urine from two colon cancer patients. In: Proceedings of the American Association for Cancer Research 1998;39:635. |
R825280 (Final) |
not available |
| Proceedings | The identification of PhIP metabolites in human urine and blood: a correlation of metabolite profiles and phenotype. In: Proceedings of the American Association for Cancer Research 1999;40:151. |
R825280 (Final) |
not available |
| Proceedings | Glucuronidation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) By a human recombinant UDP-glucuronosyltransferase. In: Proceedings of the American Association for Cancer Research 1999;40:740. |
R825280 (Final) |
not available |
| Proceedings | Glucuronidation of N-hydroxy-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP) by human intestinal microsomes. In: ISSX Proceedings 1998;13:176. |
R825280 (Final) |
not available |
| Proceedings | Relationship of SULT1A1 genotype to sulfotransferase activity phenotype in platelet cytosol: effect of genotype on heterocyclic amine activation. In: Proceedings of the American Association for Cancer Research 2000;41. |
R825280 (Final) |
not available |
| Proceedings | Genetic polymorphisms in human liver and colon sulfotransferases (SULTs) involved in the bioactivation of carcinogenic N-hydroxy aromatic and heterocyclic amines. In: Proceedings of the American Association for Cancer Research 1997;38:A2363. |
R825280 (Final) |
not available |
| Proceedings | Sinha R, Chow WH, Kuldorf M, Denoble J, Lang NP, Kadlubar FF, Hoover RN, Rothman N. Well done, grilled red meat, 1-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), metabolizing enzymes, and risk of colorectal adenomas. In: Proceedings of the American Association for Cancer Research 1998;39:365. |
R825280 (Final) |
not available |
| Proceedings | Identification and characterization of a novel polymorphic variant of human alpha-class GSTA2. In: Proceedings of the American Association for Cancer Research 2000;41. |
R825280 (Final) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.