Grantee Research Project Results
Publications Details for Grant Number R826301
Species-Specific Endocrine Disruption: PCB- and PAH-Induced Estrogenic Effects
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Reference Type | Citation | Progress Report Year | Document Sources |
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Book Chapter | Zacharewski T, Fertuck K, Fielden M, Matthews J. Mechanistically-based assays for the identification and characterization of endocrine disruptors. In: Vanden Heuvel JP, Greenlee WF, Perdew GH, Mattes WB, eds. Comprehensive Toxicology Volume 14: Cellular and Molecular Toxicology. Elsiever Science B.V., Amsterdam, The Netherlands, 2002, pp. 559-582. |
R826301 (2001) R826301 (Final) R827402 (2001) R827402 (Final) |
not available |
Journal Article | Celius T, Matthews JB, Giesy JP, Zacharewski TR. Quantification of rainbow trout (Oncorhynchus mykiss) zona radiata and vitellogenin mRNA levels using real-time PCR after in vivo treatment with estradiol-17 beta or alpha-zearalenol. Journal of Steroid Biochemistry and Molecular Biology 2000;75(2-3):109-119. |
R826301 (2000) R826301 (Final) |
not available |
Journal Article | Fertuck KC, Matthews JB, Zacharewski TR. Hydroxylated benzo[a]pyrene metabolites are responsible for in vitro estrogen receptor-mediated gene expression induced by benzo[a]pyrene, but do not elicit uterotrophic effects in vivo. Toxicological Sciences 2001;59(2):231-240. |
R826301 (2001) R826301 (Final) |
not available |
Journal Article | Fertuck KC, Kumar S, Sikka HC, Matthews JB, Zacharewski TR. Interaction of PAH-related compounds with the α and β isoforms of estrogen receptor. Toxicology Letters 2001;121(3):167-177. |
R826192 (Final) R826301 (2001) R826301 (Final) |
not available |
Journal Article | Huang YW, Matthews JB, Fertuck KC, Zacharewski TR. Use of Xenopus laevis as a model for investigating in vitro and in vivo endocrine disruption in amphibians. Environmental Toxicology and Chemistry 2005;24(8):2002-2009 |
R826301 (Final) |
not available |
Journal Article | Matthews JB, Twomey K, Zacharewski TR. In vitro and in vivo interactions of bisphenol A and its metabolite, bisphenol A glucuronide, with estrogen receptors alpha and beta. Chemical Research in Toxicology 2001;14(2):149-157 |
R826301 (Final) |
not available |
Journal Article | Matthews JB, Clemons JH, Zacharewski TR. Reciprocal mutagenesis between human α(L349, M528) and rainbow trout (M317, I496) estrogen receptor residues demonstrates their importance in ligand binding and gene expression at different temperatures. Molecular and Cellular Endocrinology 2001;183(1-2):127-139 |
R826301 (2001) R826301 (Final) |
not available |
Journal Article | Matthews JB, Fertuck KC, Celius T, Huang YW, Fong CJ, Zacharewski TR. Ability of structurally diverse natural products and synthetic chemicals to induce gene expression mediated by estrogen receptors from various species. Journal of Steroid Biochemistry and Molecular Biology 2002;82(2-3):181-194 |
R826301 (Final) |
not available |
Journal Article | Matthews J, Zacharewski T. Differential binding affinities of PCBs, HO-PCBs, and aroclors with recombinant human, rainbow trout (Onchorhynkiss mykiss), and green anole (Anolis carolinensis) estrogen receptors, using a semi-high throughput competitive binding assay. Toxicological Sciences 2000;53(2):326-339. |
R826301 (1999) R826301 (Final) |
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Journal Article | Matthews J, Celius T, Halgren R, Zacharewski T. Differential estrogen receptor binding of estrogenic substances: a species comparison. Journal of Steroid Biochemistry and Molecular Biology 2000;74(4):223-234. |
R826301 (2001) |
not available |
Journal Article | Rosen G, O'Bryant E, Matthews J, Zacharewski T, Wade J. Distribution of androgen receptor mRNA expression and immunoreactivity in the brain of the green anole lizard. Journal of Neuroendocrinology 2002;14(1):19-28. |
R826301 (2001) R826301 (Final) |
not available |
Presentation | Celius T, Matthews JB, Villalobos SA, Giesy JP, Zacharewski TR. Cloning of zona radiata proteins from rainbow trout (Oncorhynchus mykiss), a marker for investigating estrogenic endocrine modulators in fish. Presented to the European Society of Environmental Toxicology and Chemistry, England, May 21-25, 2000. |
R826301 (1999) R826301 (2000) R826301 (Final) |
not available |
Presentation | Celius T, Matthews JB, Giesy J, Zacharewski TR. Cloning of zona radiata proteins from rainbow trout (Oncorhynchus mykiss): a marker for investigating estrogenic endocrine modulators in fish. Presented at the 39th Annual Society of Toxicology Meeting, Philadelphia, PA, March 19-24, 2000. |
R826301 (1999) R826301 (2000) R826301 (Final) |
not available |
Presentation | Clemons JC, Matthews JB, Zacharewski TR. Development of a rainbow trout recombinant receptor reporter gene bioassay to screen for potential estrogenicity of environmental contaminants in fish. Presented at the 38th Annual Meeting of the Society of Toxicology, New Orleans, LA, March 15, 1999. |
R826301 (1999) R826301 (Final) |
not available |
Presentation | Fertuck KC, Matthews JB, Zacharewski TR. Comparison of in vitro binding and gene expression of benzo[a]pyrene and two hydroxylated benzo[a]pyrene metabolites mediated through estrogen receptors a and b. Presented at the 39th Annual Society of Toxicology Meeting, Philadelphia, PA, March 19-24, 2000. |
R826301 (1999) R826301 (2000) R826301 (Final) |
not available |
Presentation | Fertuck KC, Matthews JB, Clemons JC, Fielden MR, Zacharewski TR. Estrogen receptor-mediated activities of benzo[a]pyrene: receptor binding, induction of gene expression and uterotrophic effects. Presented at the 38th Annual Meeting of the Society of Toxicology, New Orleans, LA, March 15, 1999. |
R826301 (1999) R826301 (Final) |
not available |
Presentation | Fertuck KC, Sikka H, Matthews JB, Zacharewski TR. Preferential interaction of polyaromatic hydrocarbons (PAH)-related compounds with the beta isoform of the estrogen receptor. Presented at the 40th Annual Meeting of the Society of Toxicology, San Francisco, CA, March 25-29, 2001. |
R826301 (2001) |
not available |
Presentation | Huang YW, Matthews JB, Zacharewski T. Establishment of Xenophus laevis as a model for investigating in vitro and in vivo endocrine disruption in amphibians. Presented at the 39th Annual Society of Toxicology Meeting, Philadelphia, PA, March 19-24, 2000. |
R826301 (2000) |
not available |
Presentation | Huang Y-W, Matthews JB, Zacharewski TR. Establishment of Xenopus leavis as a model for investigating in vitro and in vivo endocrine disruption in amphibians. Presented at the 39th Annual Society of Toxicology Meeting, Philadelphia, PA, March 19-24, 2000. |
R826301 (1999) R826301 (Final) |
not available |
Presentation | Matthews JB, Zacharewski T. Comparison of the interactions of Bisphenol A and its metabolite, Bisphenol A glucuronide with estrogen receptor a and a. Presented at the 39th Annual Society of Toxicology Meeting, Philadelphia, PA, March 19-24, 2000. |
R826301 (2000) |
not available |
Presentation | Matthews JB, Celius T, Halgren R, Zacharewski TR. Differential estrogen receptor binding of estrogenic substances: a species comparison. Presented at the 39th Annual Society of Toxicology Meeting, Philadelphia, PA, March 19-24, 2000. |
R826301 (1999) R826301 (2000) R826301 (Final) |
not available |
Presentation | Matthews JB, Zacharewski T. Examination of the differential binding affinities polychlorinated biphenyls (PCBs), pentachloro-4-biphenyls (HO-PCBs) and Aroclors with recombinant human, rainbow trout (Onchorhynchus mykiss) and reptilian (Anolis carolinensis) estrogen receptors. Presented at the polychlorinated biphenyl (PCB) Workshop 2000, Lexington, KY, April 10-11, 2000. |
R826301 (2000) |
not available |
Presentation | Matthews JB, Zacharewski T. Identification of residues within human estrogen receptor-alpha (Era) and rainbow trout ER that are important for interaction with estrogenic compounds: new dimensions in the regulation of gene expression. Presented at the Federation of European Biochemical Societies (FEBS) 2000 Summer School, Island of Spetses, Greece, August 22-29, 2000. |
R826301 (2000) |
not available |
Presentation | Matthews JB, Zacharewski TR. Identification of residues within human estrogen receptor-alpha (hERa) and rainbow trout estrogen receptor (rtER) that contribute to temperature sensitivity and interaction with estrogenic compounds. Presented at the 40th Annual Meeting of the Society of Toxicology, San Francisco, CA, March 25-29, 2001. |
R826301 (2001) |
not available |
Presentation | Matthews JB, Zacharewski TR. Molecular cloning of the reptilian, Anolis carolinensis, estrogen receptor ligand binding domain: comparative amino acid sequence analysis to known estrogen receptors. Presented at the 38th Annual Meeting of the Society of Toxicology, New Orleans, LA, March 16, 1999. |
R826301 (1999) R826301 (Final) |
not available |
Presentation | Matthews JB, Zacharewski TR. PCBs exhibit differential binding to recombinant human alpha and rainbow trout estrogen receptors. Presented at the 38th Annual Meeting of the Society of Toxicology, New Orleans, LA, March 18, 1999. |
R826301 (1999) R826301 (Final) |
not available |
Presentation | Rosen G, Matthews JB, Zacharewski T, Wade J. Distribution of androgen receptor messenger ribonucleic acid (mRNA) in the green anole brain. Presented to the Society of Neuroscience, New Orleans, LA, November 4-9, 2000. |
R826301 (2000) |
not available |
Presentation | Zacharewski TR, Matthews JB, Celius T, Fertuck K, Huang YW. Differential interactions of estrogenic chemicals with estrogen receptors from several different species. Presented at the 40th Annual Meeting of the Society of Toxicology, San Francisco, CA, March 25-29, 2001. |
R826301 (2001) |
not available |
Presentation | Zacharewski TR. In silico, in vitro, and in vivo assessment of estrogenic endocrine disruptors. Presented at the National Science Foundation Summer Student Program, Department of Biochemistry, Michigan State University Cancer Center, East Lansing, MI, June 29, 1999. |
R826301 (1999) R826301 (Final) |
not available |
Presentation | Zacharewski TR. In vitro assays for assessing endocrine disruptors. Presented at the Pittsburgh Conference & Exposition on Analytical Chemistry and Applied Spectroscopy, New Orleans, LA, March 16, 2000. |
R826301 (1999) R826301 (2000) R826301 (Final) |
not available |
Presentation | Zacharewski TR. In vitro assessment of estrogenic endocrine disruptors. Presented at the Society of Environmental Toxicology and Chemistry 20th Annual Meeting, Philadelphia, PA, November 17, 1999. |
R826301 (1999) R826301 (Final) |
not available |
Presentation | Zacharewski TR. Molecular basis for endocrine disruptor-estrogen receptor interactions: a species comparison. Presented at the Second Annual Endocrine Disruptors Conference, Seoul, Korea, November 24, 1999. |
R826301 (1999) R826301 (Final) |
not available |
Presentation | Zacharewski TR. Molecular basis of endocrine disruptor-estrogen receptor interaction: a species comparison. Presented at the Toxicology Students' Association-University of Guelph, Guelph, Ontario, March 4, 2000. |
R826301 (1999) R826301 (Final) |
not available |
Presentation | Zacharewski TR. Molecular basis of endocrine disruptor-estrogen receptor interactions. Presented at the Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charlotte, SC, February 10, 2000. |
R826301 (1999) R826301 (Final) |
not available |
Presentation | Zacharewski TR. The molecular basis of endocrine disruptor-estrogen receptor interactions: across species comparison. Presented to the Great Lakes Center and the Environmental Health Sciences Graduate Group, School of Medicine and Biomedical Sciences, University of Buffalo, Buffalo, NY, July 13, 1999. |
R826301 (1999) R826301 (Final) |
not available |
Presentation | Zacharewski T. Application of new technologies and implications for risk assessment. Presented at the U.S. Environmental Protection Agency Regional Workshop on Endocrine Disruptors, EPA Region 4, Atlanta, GA, May 1-3, 2001. |
R826301 (2001) R827402 (2001) R827402 (Final) |
not available |
Presentation | Zacharewski T. Assessment of estrogenic endocrine disruptors: estrogen receptor interactions, toxicogenomics and male reproductive toxicity. Presented to the Curagen Corporation, New Haven, CT, August 7, 2001. |
R826301 (2001) R827402 (Final) |
not available |
Presentation | Zacharewski T. Endocrine disruption as related to our food supply. The Science of Pre-Harvest Food Safety-Bringing Sound Science to the Table. Presented at the Kellogg Hotel and Conference Center, Michigan State University, E. Lansing, MI, May 8-10, 2001. |
R826301 (2001) R827402 (2001) R827402 (Final) |
not available |
Presentation | Zacharewski T. Endocrine disruptor-estrogen receptor interactions: the molecular basis for differential activity between species. Presented to the Institute of Cellular and Molecular Biosciences, University of Tokyo, Tokyo, Japan, January 30, 2002. |
R826301 (2001) R827402 (Final) |
not available |
Presentation | Zacharewski T. Endocrine disruptor-estrogen receptor interactions: the molecular basis for differential activity between species. Presented to the National Institute of Health Sciences, Tokyo, Japan, January 28, 2002. |
R826301 (2001) R827402 (Final) |
not available |
Presentation | Zacharewski T. Integrating toxicogenomics into predictive and mechanistic toxicology. Presented at the Lorne Genome Conference, Lorne, Australia, February 16-20, 2003. |
R826301 (2001) R827402 (Final) |
not available |
Presentation | Zacharewski T. Molecular basis for endocrine disruptor-estrogen receptor interactions: a species comparison. Presented at the National Institute of Health Sciences, Tokyo, Japan, December 13, 1999. |
R826301 (1999) R826301 (Final) |
not available |
Presentation | Zacharewski T. Molecular basis of endocrine disruptor-estrogen receptor interactions. Presented at the Medical University of South Carolina, Department of Biochemistry and Molecular Biology, Charlotte, SC, February 10, 2000. |
R826301 (2000) |
not available |
Presentation | Zacharewski T. Prioritization and screening of estrogenic endocrine disruptors using in vitro and in silico approaches. Presented at the Japanese Environment Agency's Endocrine Disruptor Conference, Kobe, Japan, December 9, 1999. |
R826301 (1999) R826301 (Final) |
not available |
Presentation | Zacharewski T. The molecular basis for endocrine disruptor-estrogen receptor interactions: a species comparison. Presented to the Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, KY, February 21, 2002. |
R826301 (2001) |
not available |
Presentation | Zacharewski T. The molecular basis of endocrine disruptor interaction differences between human and rainbow trout estrogen receptors. Presented at the 8th Annual Mount Desert Island Biological Laboratory (MDIBL) Environmental Health Sciences Symposium-Intracellular Sensors of Environmental Chemicals, Maren Conference Center, Mount Desert Island Biological Laboratory, Salabury Cove, ME, July 11-12, 2001. |
R826301 (2001) |
not available |
Presentation | Zacharewski T. Toxicogenomic approaches to assess endocrine disruptors. Presented to the National Institute of Health Sciences, Tokyo, Japan, January 29, 2002. |
R826301 (2001) R827402 (Final) |
not available |
Presentation | Zacharewski, T. Toxicogenomic assessment of endocrine disruptors. Presented at the International Symposium on Environmental Endocrine Disruptors 2001, Tsukuba, Japan, December 15-17, 2001. |
R826301 (2001) R827402 (Final) |
not available |
Presentation | Zacharewski, T. Toxicogenomic assessment strategies for estrogenic endocrine disruptors. Presented to the National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, June 5, 2002. |
R826301 (2001) R827402 (Final) |
not available |
Symposium | Zacharewski T. Assessment of estrogenic endocrine disruptors using global gene expression approaches. Scientific Committee on Problems of the Environment/International Union of Pure and Applied Chemistry-International Symposium on Endocrine Active Substances,Yokohama, Japan, November 17-21, 2002. |
R826301 (2001) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.