Grantee Research Project Results
Publications Details for Grant Number R829180
Infectivity and Virulence of Cryptosporidium Non-parvum Species in Healthy Adult Volunteers
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| Reference Type | Citation | Progress Report Year | Document Sources |
|---|---|---|---|
| Book Chapter | Chappell CL, Okhuysen PC. Cryptosporidiosis. In: Richardson DJ, Krause PJ, eds. North American Parasitic Zoonoses. Norwell, MA: Kluwer Academic Publishers, 2003: 113-128. |
R829180 (2003) R829180 (Final) |
not available |
| Book Chapter | Chappell CL, Okhuysen PC, Dupont HL, Sterling CR, Tzipori S, Thompson RCA, Armson A, Ryan UM. Cryptosporidium parvum volunteer study: Infectivity and immunity. Elsevier, Amsterdam. 2004:79-82 |
R829180 (2003) R829180 (2004) R829180 (Final) |
not available |
| Book Chapter | Chappell CL, Okhuysen PC, White AC, Thompson RCA, Armson A, Ryan UM. Cryptosporidium parvum: infectivity, pathogenesis and the host-parasite relationship. Elsevier, Amsterdam. 2004:19-50 |
R829180 (2003) R829180 (2004) R829180 (Final) |
not available |
| Journal Article | Akiyoshi DE, Dilo J, Pearson C, Chapman S, Tumwine J, Tzipori S. Characterization of Cryptosporidium meleagridis of human origin passaged through different host species. Infection and Immunity 2003;71(4):1828-1832. |
R829180 (2003) R829180 (Final) |
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| Journal Article | Alcantara CS, Yang C-H, Steiner TS, Barrett LJ, Lima AAM, Chappell CL, Okhuysen PC, White Jr AC, Guerrant RL. Interleukin-8, tumor necrosis factor-alpha, and lactoferrin in immunocompetent hosts with experimental and Brazilian children with acquired cryptosporidiosis. American Journal of Tropical Medicine and Hygiene 2003;68(3):325-328. |
R828035 (2001) R829180 (2002) |
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| Journal Article | Chappell CL, Okhuysen PC. Cryptosporidiosis. Current Opinion in Infectious Diseases 2002;15(5):523-527. |
R829180 (2002) R829180 (Final) |
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| Journal Article | Huang K, Akiyoshi DE, Feng X, Tzipori S. Development of patent infection in immunosuppressed C57BL/6 mice with a single Cryptosporidium meleagridis oocyst. Journal of Parasitology 2003;89(3):620-622. |
R829180 (2003) R829180 (Final) |
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| Journal Article | Kjos SA, Jenkins M, Okhuysen PC, Chappell CL. Evaluation of recombinant oocyst protein CP41 for detection of Cryptosporidium-specific antibodies. Clinical and Diagnostic Laboratory Immunology 2005;12(2):268-272. |
R829180 (2004) R829180 (Final) |
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| Journal Article | Messner MJ, Chappell CL, Okhuysen PC. Risk assessment for Cryptosporidium: a hierarchical Bayesian analysis of human dose response data. Water Research 2001;35(16):3934-3940. |
R828035 (2001) R829180 (2002) |
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| Journal Article | Okhuysen PC, Robinson P, Nguyen MT, Nannini EC, Lewis DE, Janecki A, Chappell CL, White Jr AC. Jejunal cytokine response in AIDS patients with chronic cryptosporidiosis and during immune reconstitution. AIDS 2001;15(6):802-804. |
R829180 (2002) |
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| Journal Article | Okhuysen PC, Chappell CL. Cryptosporidium virulence determinants – are we there yet? International Journal for Parasitology 2002;32(5):517-525. |
R828035 (2001) R829180 (2002) R829180 (Final) |
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| Journal Article | Okhuysen PC, Rich SM, Chappell CL, Grimes KA, Widmer G, Feng X, Tzipori S. Infectivity of a Cryptosporidium parvum isolate of cervine origin for healthy adults and interferon-gamma knockout mice. Journal of Infectious Diseases 2002;185(9):1320-1325. |
R828035 (2001) R829180 (2002) |
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| Journal Article | Okhuysen PC, Rogers GA, Crisanti A, Spano F, Huang DB, Chappell CL, Tzipori S. Antibody response of healthy adults to recombinant thrombospondin-related adhesive protein of Cryptosporidium 1 after experimental exposure to Cryptosporidium oocysts. Clinical and Diagnostic Laboratory Immunology 2004;11(2):235-238. |
R829180 (2004) |
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| Journal Article | Padda RS, Tsai A, Chappell CL, Okhuysen PC. Molecular cloning and analysis of the Cryptosporidium parvum aminopeptidase N gene. International Journal for Parasitology 2002;32(2):187-197. |
R828035 (2001) R829180 (2002) |
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| Journal Article | Robinson P, Okhuysen PC, Chappell CL, Lewis DE, Shahab I, Lahoti S, White Jr AC. Expression of IL-15 and IL-4 in IFN-gamma-independent control of experimental human Cryptosporidium parvum infection. Cytokine 2001;15(1):39-46. |
R829180 (2002) |
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| Journal Article | Robinson P, Okhuysen PC, Chappell CL, Weinstock JV, Lewis DE, Actor JK, White Jr AC. Substance P expression correlates with severity of diarrhea in cryptosporidiosis. The Journal of Infectious Diseases 2003;188(2):290-296. |
R829180 (2003) |
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| Journal Article | Teunis PFM, Chappell CL, Okhuysen PC. Cryptosporidium dose-response studies: variation between hosts. Risk Analysis 2002;22(3):475-485. |
R828035 (2001) R829180 (2002) |
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| Presentation | Chappell CL, Okhuysen PC, Langer R, Tzipori S. Experimental challenge of healthy adult volunteers with Cryptosporidium muris oocysts. Presented at the 52nd Annual Meeting of the American Society of Tropical Medicine and Hygiene, Philadelphia, PA, December 3-7, 2003. |
R829180 (2004) |
not available |
| Presentation | Chappell CL. Cryptosporidium parvum: infectivity, pathogenesis and the host-parasite relationship. Presented at Texas A&M University, College Station, TX, December 10, 2002. |
R829180 (2003) |
not available |
| Presentation | Chappell CL, Okhuysen P, Langer R, Akiyoshi D, Tzipori S. Experimental infection of healthy adults with Cryptosporidium genotype 1 isolate (TU502). Presented at the 78th Annual Meeting of the American Society of Parasitologists, Halifax, Nova Scotia, August 1-5, 2003. |
R829180 (2003) |
not available |
| Presentation | Chappell C. Cryptosporidium in healthy adults: infectivity, pathogenesis and the host-parasite relationship. Presented at the International Cryptosporidium from Molecules to Disease Conference, Fremantle, Australia, October 7-12, 2001. |
R828035 (2001) R829180 (2002) |
not available |
| Presentation | Chappell C. Cryptosporidium in healthy humans: how infectious are they? Presented at the 51st Annual Conference on Diseases in Nature Transmissible to Man, Austin, Texas, May 31-June 2, 2001. |
R828035 (2001) R829180 (2002) |
not available |
| Presentation | Chappell C. Cryptosporidium parvum volunteer study: infectivity and immunity. Presented at the Australian Society of Microbiology, Perth, Australia, September 30-October 5, 2001. |
R829180 (2002) |
not available |
| Presentation | Dann SM, Robinson P, Okhuysen PC, White AC, Chappell CL. B-cell and secretory IgA responses to Cryptosporidium parvum infection in healthy volunteers. Presented at the 11th International Congress of Mucosal Immunology, Orlando, FL, June 16-20, 2002. |
R829180 (2003) |
not available |
| Presentation | Langer RC, Okhuysen PC, Tzipori S, Sterling CR, Chappell CL. Cryptosporidium IgG antibodies in healthy adults is dependent upon the infecting genotype. Presented at the 78th Annual Meeting of the American Society of Parasitologists, Halifax, Nova Scotia, August 1-5, 2003. |
R829180 (2003) |
not available |
| Presentation | Langer R, Okhuysen P, Tzipori S, Sterling C, Chappell CL. Cryptosporidium IgG antibodies in healthy adults is dependent upon the infecting genotype. Presented at the Gulf Coast Tropical Medicine Association Meeting, Galveston, TX, April 25-26, 2003. |
R829180 (2003) R829180 (2004) |
not available |
| Presentation | Lupo PJ, Langer RC, Chappell CL. Preliminary study of Cryptosporidium in kennelled dogs. Presented at the Gulf Coast Tropical Medicine Association Meeting, Galveston, TX, April 25-26, 2003. |
R829180 (2003) |
not available |
| Proceedings | Chappell CL, Okhuysen PC. Virulence determinants of Cryptosporidium-are we there yet? In: Proceedings of the VII International Coccidiosis Meeting, Australian Society of Parasitology, Palm Cove, Cairns, Australia, July 2001. |
R828035 (2001) R829180 (2002) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.