Grantee Research Project Results
Publications Details for Grant Number R840027
Integrated blood brain barrier computational model development to predict doses of concern for compound linked neurotoxicity
RFA:
Advancing Toxicokinetics for Efficient and Robust Chemical Evaluations (2019)
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| Reference Type | Citation | Progress Report Year | Document Sources |
|---|---|---|---|
| Journal Article | Lubin K, Xu Z, Sluka J, Knipp G. Development of an in vitro model of the neurovascular unit for BBB permeability-linked neuroactivity screening. Medicinal Chemistry Research 2024;33:1450-1463. |
R840027 (2023) R840027 (2024) |
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| Journal Article | Lubin KE, Knipp GT. Design of experiment based optimization of an in vitro direct contact triculture blood brain barrier model for permeability screening. Pharmacy and Pharmacology International Journal 2021;9(4):143-158. |
R840027 (2024) |
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| Journal Article | Sego TJ, Sluka JP, Sauro HM, Glazier JA. Tissue forge:interactive biological and biophysics simulation environment. PLOS Computational Biology 2023;19(10):e1010768. |
R840027 (2024) |
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| Journal Article | Zha L, Matsu-Ura T, Sluka JP, Murakawa T, Tsuta K. Morphological basis of the lung adenocarcinoma subtypes. IScience 2024;27(5). |
R840027 (2024) |
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| Journal Article | Wittner R, Holub P, Mascia C, Frexia F, Müller H, Plass M, Allocca C, Betsou F, Burdett T, Cancio I, Chapman A. Toward a common standard for data and specimen provenance in life sciences. Learning Health Systems 2024;8(1):e10365. |
R840027 (2024) |
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| Journal Article | Holub P, Wittner R, Mascia C, Frexia F, Müller H, Plass M, Allocca C, Betsou F, Burdett T, Cancio I, Chapman A. Towards a Common Standard for Data and Specimen Provenance in Life Sciences. Zenodo 2021. |
R840027 (2022) |
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| Presentation | Sluka JP, Zhang CC, Knipp GT. Coupled in vitro BBB triculture assay and computational model development to predict doses of concern for neurotoxicity. Poster presented at the Society of Toxicology (SOT) Meeting, Nashville, TN, March 19-22, 2023. |
R840027 (2024) |
not available |
| Presentation | Sluka J, Zhang C, Knipp G. Coupled in vitro BBB triculture assay and computational model development to predict doses of concern for neurotoxicity. Poster presented at the Interagency Modeling and Analysis Group/Multiscale Modeling (IMAG/MSM) Meeting, Bethesda, MD, June 28-29, 2023. |
R840027 (2024) |
not available |
| Presentation | Unnikrishnan A, Chang X, Hull V, Tedla GE, Hogberg-Durdock H, Allen D, Kleinstreuer N, Sluka J, Wambaugh J. Expanding PBPK modeling to predict chemical distribution in brain and adipose tissues. Poster presented at the 12th World Congress on Alternatives and Animal Use in the Life Sciences (WC12), Niagara Falls, Canada, August 27-31, 2023. |
R840027 (2024) |
not available |
| Presentation | Unnikrishnan A, Chang X, Hull V, Tedla GE, Hogberg-Durdock H, Allen D, Kleinstreuer N, Sluka J, Wambaugh J. Expanding PBPK modeling to predict chemical distribution in brain and adipose tissues. Poster presented at the American Society for Cellular and Computational Toxicology Annual Meeting, Silver Spring, MD, October 23-25, 2023. |
R840027 (2024) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.