Grantee Research Project Results
Publications Details for Grant Number R835737C002
Brain MAPs
RFA:
Organotypic Culture Models for Predictive Toxicology Center (2013)
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Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
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Journal Article | Micropatterned, clickable culture substrates enable in situ spatiotemporal control of human PSC-derived neural tissue morphology. | CHEMICAL COMMUNICATIONS | Knight GT, Sha J, Ashton RS | Knight GT, Sha J, Ashton RS. Micropatterned, clickable culture substrates enable in situ spatiotemporal control of human PSC-derived neural tissue morphology. Chemical Communications 2015;51(25):5238-5241. |
R835737 (2015) R835737 (2016) R835737C002 (2015) R835737C002 (2016) |
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Journal Article | Engineering induction of singular neural rosette emergence within jPSC-derived tissues. | None | Knight GT, Lundin BF, Iyer N, Ashton LMT, Sethares WA, Willett RM, Ashton RS | Knight GT, Lundin BF, Iyer N, Ashton LMT, Sethares WA, Willett RM, Ashton RS. Engineering induction of singular neural rosette emergence within jPSC-derived tissues. eLIFE 2018;7:e37549 (23 pp.). |
R835737 (2017) R835737 (Final) R835737C002 (2017) |
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Journal Article | Deriving, regenerating, and engineering CNS tissues using human pluripotent stem cells. | None | Lemke KA, Aghayee A, Ashton RS | Lemke KA, Aghayee A, Ashton RS. Deriving, regenerating, and engineering CNS tissues using human pluripotent stem cells. Current Opinion in Biotechnology 2017;47:36-42. |
R835737 (2017) R835737C002 (2017) |
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Journal Article | The case for applying tissue engineering methodologies to instruct human organoid morphogenesis. | None | Marti-Figueroa CR, Ashton RS | Marti-Figueroa CR, Ashton RS. The case for applying tissue engineering methodologies to instruct human organoid morphogenesis. Acta Biomaterialia 2017;54:35-44. |
R835737 (2017) R835737C002 (2017) |
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Patent/Patent Application | Methods and culture substrates for controlled induction of biomimetic neural tissues comprising singular rosettes structures. | None | Ashton RS, Knight GT. | Ashton RS, Knight GT. Methods and culture substrates for controlled induction of biomimetic neural tissues comprising singular rosettes structures. U.S. Patent No. 16/044236, 2019. |
R835737 (2017) R835737C002 (2017) |
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Presentation | Engineering CNS tissue morphogenesis ex vivo. | None | Ashton RS | Ashton RS. Engineering CNS tissue morphogenesis ex vivo. Presented at the Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore, MD, March 15, 2017 (invited). |
R835737 (2017) R835737C002 (2017) |
not available |
Presentation | Engineering CNS tissue morphogenesis ex vivo. | None | Ashton RS | Ashton RS. Engineering CNS tissue morphogenesis ex vivo. Presented to the Department of Biomedical Engineering, Rutgers University, Piscataway, NJ, March 20, 2017 (invited). |
R835737 (2017) R835737C002 (2017) |
not available |
Presentation | Towards an in vitro model of the human posterior CNS. | None | Estevez Silva MC, Knight GT, Lippmann E, Chasman D , Roy S, Ashton RS | Estevez Silva MC, Knight GT, Lippmann E, Chasman D , Roy S, Ashton RS. Towards an in vitro model of the human posterior CNS. Presented at the Neurological Disorders: Transforming the Landscape with hPSC Modeling Focus Session, International Society for Stem Cell Research Annual Meeting, Boston, MA, June 14, 2017 (invited). |
R835737 (2017) R835737C002 (2017) |
not available |
Presentation | Engineering human CNS morphogenesis in 2/3D: controlled induction of neural rosette formation. | None | Knight GT, Lundin BF, Ashton LMT, Sethares WA, Willett RL, Ashton RS | Knight GT, Lundin BF, Ashton LMT, Sethares WA, Willett RL, Ashton RS. Engineering human CNS morphogenesis in 2/3D:controlled induction of neural rosette formation. Presented at EDEV2017: Engineering Multicellular Self-Organization, École Polytechnique Fédérale De Lausanne, Lausanne, Switzerland, November 14, 2017 (invited). |
R835737 (2017) R835737C002 (2017) |
not available |
Presentation | Brain models for analysis of pathways brain-MAPS. | None | Knight G, Ashton RS | Knight G, Ashton RS. Brain models for analysis of pathways brain-MAPS. Presented at the 10th World Congress of Alternatives and Animal Use in the Life Sciences, Seattle, WA August 22, 2017 (invited). |
R835737 (2017) R835737C002 (2017) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.